PMID- 33923651
OWN - NLM
STAT- MEDLINE
DCOM- 20210524
LR  - 20240401
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 26
IP  - 8
DP  - 2021 Apr 16
TI  - Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking 
      ROCK Signalling.
LID - 10.3390/molecules26082320 [doi]
LID - 2320
AB  - Curcumin is a natural compound that has been widely used as a food additive and 
      medicine in Asian countries. Over several decades, diverse biological effects of 
      curcumin have been elucidated, such as anti-inflammatory and anti-oxidative 
      activities. Monocyte chemoattractant protein-1 (MCP-1) is a key inflammatory 
      marker during the development of atherosclerosis, and curcumin blocks MCP-1 
      expression stimulated by various ligands. Hence, we studied the action of 
      curcumin on lysophosphatidic acid (LPA) mediated MCP-1 expression and explored 
      the specific underlying mechanisms. In human vascular smooth muscle cells, LPA 
      induces Rho-associated protein kinase (ROCK) dependent transforming growth factor 
      receptor (TGFBR1) transactivation, leading to glycosaminoglycan chain elongation. 
      We found that LPA also signals via the TGFBR1 transactivation pathway to regulate 
      MCP-1 expression. Curcumin blocks LPA mediated TGFBR1 transactivation and 
      subsequent MCP-1 expression by blocking the ROCK signalling. In the vasculature, 
      ROCK signalling regulates smooth muscle cell contraction, inflammatory cell 
      recruitment, endothelial dysfunction and vascular remodelling. Therefore, 
      curcumin as a ROCK signalling inhibitor has the potential to prevent 
      atherogenesis via multiple ways.
FAU - Zhou, Ying
AU  - Zhou Y
AD  - School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of 
      Queensland, Woolloongabba, QLD 4102, Australia.
FAU - Little, Peter J
AU  - Little PJ
AUID- ORCID: 0000-0002-0335-3835
AD  - School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of 
      Queensland, Woolloongabba, QLD 4102, Australia.
AD  - Department of Pharmacy, Xinhua College of Sun Yat-sen University, Tianhe 
      District, Guangzhou 510520, China.
AD  - Sunshine Coast Health Institute, University of the Sunshine Coast, Birtinya, QLD 
      4575, Australia.
FAU - Xu, Suowen
AU  - Xu S
AUID- ORCID: 0000-0002-5488-5217
AD  - Department of Endocrinology, First Affiliated Hospital, Division of Life Sciences 
      and Medicine, University of Science and Technology of China, Hefei 230037, China.
FAU - Kamato, Danielle
AU  - Kamato D
AUID- ORCID: 0000-0002-1089-2829
AD  - School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of 
      Queensland, Woolloongabba, QLD 4102, Australia.
AD  - Department of Pharmacy, Xinhua College of Sun Yat-sen University, Tianhe 
      District, Guangzhou 510520, China.
LA  - eng
GR  - 1160925/National Health and Medical Research Council/
GR  - 1832825/University of Queensland/
PT  - Journal Article
DEP - 20210416
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lysophospholipids)
RN  - 0 (Receptors, Transforming Growth Factor beta)
RN  - EC 2.7.11.1 (rho-Associated Kinases)
RN  - IT942ZTH98 (Curcumin)
RN  - PG6M3969SG (lysophosphatidic acid)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Chemokine CCL2/*metabolism
MH  - Curcumin/*pharmacology
MH  - Humans
MH  - Inflammation/metabolism
MH  - Lysophospholipids/*pharmacology
MH  - Muscle, Smooth, Vascular/drug effects/metabolism
MH  - Receptors, Transforming Growth Factor beta/metabolism
MH  - Signal Transduction/drug effects
MH  - rho-Associated Kinases/*metabolism
PMC - PMC8073974
OTO - NOTNLM
OT  - Smad2
OT  - atherosclerosis
OT  - inflammation
OT  - monocyte chemoattractant protein-1
OT  - transforming growth factor receptor
OT  - vascular smooth muscle cells
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/25 06:00
PMCR- 2021/04/16
CRDT- 2021/04/30 01:25
PHST- 2021/03/22 00:00 [received]
PHST- 2021/04/12 00:00 [revised]
PHST- 2021/04/14 00:00 [accepted]
PHST- 2021/04/30 01:25 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/25 06:00 [medline]
PHST- 2021/04/16 00:00 [pmc-release]
AID - molecules26082320 [pii]
AID - molecules-26-02320 [pii]
AID - 10.3390/molecules26082320 [doi]
PST - epublish
SO  - Molecules. 2021 Apr 16;26(8):2320. doi: 10.3390/molecules26082320.