PMID- 33924046
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210518
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 13
IP  - 4
DP  - 2021 Apr 20
TI  - Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery 
      Nanocarriers.
LID - 10.3390/pharmaceutics13040587 [doi]
LID - 587
AB  - In recent decades, drug delivery systems (DDSs) based on nanotechnology have been 
      attracting substantial interest in the pharmaceutical field, especially those 
      developed based on natural polymers such as chitosan, cellulose, starch, 
      collagen, gelatin, alginate and elastin. Nanomaterials based on chitosan (CS) or 
      chitosan derivatives are broadly investigated as promising nanocarriers due to 
      their biodegradability, good biocompatibility, non-toxicity, low immunogenicity, 
      great versatility and beneficial biological effects. CS, either alone or as 
      composites, are suitable substrates in the fabrication of different types of 
      products like hydrogels, membranes, beads, porous foams, nanoparticles, in-situ 
      gel, microparticles, sponges and nanofibers/scaffolds. Currently, the CS based 
      nanocarriers are intensely studied as controlled and targeted drug release 
      systems for different drugs (anti-inflammatory, antibiotic, anticancer etc.) as 
      well as for proteins/peptides, growth factors, vaccines, small DNA (DNAs) and 
      short interfering RNA (siRNA). This review targets the latest biomedical 
      approaches for CS based nanocarriers such as nanoparticles (NPs) nanofibers 
      (NFs), nanogels (NGs) and chitosan coated liposomes (LPs) and their potential 
      applications for medical and pharmaceutical fields. The advantages and challenges 
      of reviewed CS based nanocarriers for different routes of administration (oral, 
      transmucosal, pulmonary and transdermal) with reference to classical formulations 
      are also emphasized.
FAU - Iacob, Andreea Teodora
AU  - Iacob AT
AD  - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa 
      University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, 
      Romania.
FAU - Lupascu, Florentina Geanina
AU  - Lupascu FG
AD  - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa 
      University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, 
      Romania.
FAU - Apotrosoaei, Maria
AU  - Apotrosoaei M
AD  - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa 
      University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, 
      Romania.
FAU - Vasincu, Ioana Mirela
AU  - Vasincu IM
AD  - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa 
      University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, 
      Romania.
FAU - Tauser, Roxana Georgiana
AU  - Tauser RG
AD  - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa 
      University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, 
      Romania.
FAU - Lupascu, Dan
AU  - Lupascu D
AD  - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa 
      University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, 
      Romania.
FAU - Giusca, Simona Eliza
AU  - Giusca SE
AD  - Department of Morphofunctional Sciences, Faculty of Medicine, Grigore T. Popa 
      University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, 
      Romania.
FAU - Caruntu, Irina-Draga
AU  - Caruntu ID
AD  - Department of Morphofunctional Sciences, Faculty of Medicine, Grigore T. Popa 
      University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, 
      Romania.
FAU - Profire, Lenuta
AU  - Profire L
AUID- ORCID: 0000-0002-7953-3023
AD  - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa 
      University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, 
      Romania.
LA  - eng
GR  - 27496/20.12.2018/Grigore T. Popa University of Medicine and Pharmacy of Iasi/
GR  - 23401/07.11.2018/Grigore T. Popa University of Medicine and Pharmacy of Iasi/
GR  - 28/2019/AUF-IFA 2019-2020/
PT  - Journal Article
PT  - Review
DEP - 20210420
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC8073149
OTO - NOTNLM
OT  - chitosan
OT  - drug delivery systems
OT  - liposomes
OT  - nanocarriers
OT  - nanofibers
OT  - nanogels
OT  - nanoparticles
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/01 06:01
PMCR- 2021/04/20
CRDT- 2021/04/30 01:27
PHST- 2021/03/31 00:00 [received]
PHST- 2021/04/13 00:00 [revised]
PHST- 2021/04/16 00:00 [accepted]
PHST- 2021/04/30 01:27 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/01 06:01 [medline]
PHST- 2021/04/20 00:00 [pmc-release]
AID - pharmaceutics13040587 [pii]
AID - pharmaceutics-13-00587 [pii]
AID - 10.3390/pharmaceutics13040587 [doi]
PST - epublish
SO  - Pharmaceutics. 2021 Apr 20;13(4):587. doi: 10.3390/pharmaceutics13040587.