PMID- 33924190
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210502
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 8
DP  - 2021 Apr 20
TI  - Sex Differences in the Incidence and Outcomes of Acute Myocardial Infarction in 
      Spain, 2016-2018: A Matched-Pair Analysis.
LID - 10.3390/jcm10081795 [doi]
LID - 1795
AB  - (1) Background: Our aim was to analyze the incidence, procedures, and in-hospital 
      outcomes of myocardial infarction (MI) in Spain (2016-2018) according to sex. (2) 
      Methods: We estimated the incidence of an ST elevation myocardial infarction 
      (STEMI) and non-ST elevation myocardial infarction (NSTEMI) according to sex 
      using the Spanish National Hospital Discharge Database. A matched-pair analysis 
      was used. (3) Results: MI was coded in 156,826 patients aged >/=18 years (111,842 
      men and 44,984 women). Men showed higher incidence rates (205.0 vs. 77.8 per 
      100,000; p < 0.001; IRR = 2.81(95%CI:2.78-2.84)). After matching, the use of 
      coronary artery by-pass grafting (CABG) (1.0% vs. 0.7%; p < 0.001) and 
      percutaneous coronary intervention (PCI) (57.8% vs. 52.3%; p < 0.001) was higher 
      among men with an STEMI, whereas the in-hospital mortality (IHM) remained higher 
      among women (11.2% vs. 10.1%; p < 0.001). Likewise, CABG (1.9% vs. 3.3%; p < 
      0.001) and PCI (33.8% vs. 41.9%; p < 0.001) were less often used among women with 
      an NSTEMI, but no sex-related differences were found in IHM. After adjusting for 
      confounders, IHM was more than twofold higher for both men and women with an 
      STEMI than those with an NSTEMI. Women with an STEMI had a 21% higher mortality 
      risk than men (OR = 1.21(95%CI:1.13-1.29). (4) Conclusion: Men had higher 
      incidence rates of MI than women. Women underwent invasive procedures less often 
      and had a higher IHM when admitted for an STEMI.
FAU - de Miguel-Yanes, Jose M
AU  - de Miguel-Yanes JM
AUID- ORCID: 0000-0003-2802-033X
AD  - Internal Medicine Department, Hospital General Universitario Gregorio Maranon, 
      Instituto de Investigacion Sanitaria Gregorio Maranon (IiSGM), Universidad 
      Complutense de Madrid, 28040 Madrid, Spain.
FAU - Jimenez-Garcia, Rodrigo
AU  - Jimenez-Garcia R
AUID- ORCID: 0000-0001-6119-4222
AD  - Department of Public Health & Maternal and Child Health, Faculty of Medicine, 
      Universidad Complutense de Madrid, 28040 Madrid, Spain.
FAU - Hernandez-Barrera, Valentin
AU  - Hernandez-Barrera V
AD  - Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences 
      Faculty, Universidad Rey Juan Carlos, Alcorcon, 28922 Madrid, Spain.
FAU - de Miguel-Diez, Javier
AU  - de Miguel-Diez J
AUID- ORCID: 0000-0003-4543-573X
AD  - Respiratory Care Department, Hospital General Universitario Gregorio Maranon, 
      Instituto de Investigacion Sanitaria Gregorio Maranon (IiSGM), Universidad 
      Complutense de Madrid, 28040 Madrid, Spain.
FAU - Munoz-Rivas, Nuria
AU  - Munoz-Rivas N
AUID- ORCID: 0000-0001-9774-963X
AD  - Internal Medicine Department, Hospital Universitario Infanta Leonor, 28031 
      Madrid, Spain.
FAU - Mendez-Bailon, Manuel
AU  - Mendez-Bailon M
AD  - Internal Medicine Department, Hospital Universitario Clinico San Carlos, 
      Universidad Complutense de Madrid, 28040 Madrid, Spain.
FAU - Perez-Farinos, Napoleon
AU  - Perez-Farinos N
AUID- ORCID: 0000-0001-7936-1172
AD  - Public Health and Psychiatry Department, Faculty of Medicine, Universidad de 
      Malaga, 29010 Malaga, Spain.
FAU - Lopez-Herranz, Marta
AU  - Lopez-Herranz M
AD  - Nursing Department, Faculty of Nursing, Physiotherapy and Podology, Universidad 
      Complutense de Madrid, 28040 Madrid, Spain.
FAU - Lopez-de-Andres, Ana
AU  - Lopez-de-Andres A
AUID- ORCID: 0000-0001-5551-5181
AD  - Department of Public Health & Maternal and Child Health, Faculty of Medicine, 
      Universidad Complutense de Madrid, 28040 Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20210420
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8074598
OTO - NOTNLM
OT  - NSTEMI
OT  - STEMI
OT  - gender
OT  - in-hospital mortality
OT  - myocardial infarction
OT  - sex differences
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/01 06:01
PMCR- 2021/04/20
CRDT- 2021/04/30 01:27
PHST- 2021/02/12 00:00 [received]
PHST- 2021/04/15 00:00 [revised]
PHST- 2021/04/19 00:00 [accepted]
PHST- 2021/04/30 01:27 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/01 06:01 [medline]
PHST- 2021/04/20 00:00 [pmc-release]
AID - jcm10081795 [pii]
AID - jcm-10-01795 [pii]
AID - 10.3390/jcm10081795 [doi]
PST - epublish
SO  - J Clin Med. 2021 Apr 20;10(8):1795. doi: 10.3390/jcm10081795.