PMID- 33925205
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210527
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 9
IP  - 5
DP  - 2021 Apr 28
TI  - Tumor-Infiltrating Lymphocytes in the Tumor Microenvironment of Laryngeal 
      Squamous Cell Carcinoma: Systematic Review and Meta-Analysis.
LID - 10.3390/biomedicines9050486 [doi]
LID - 486
AB  - The presence of tumor-infiltrating lymphocytes (TIL) in the tumor 
      microenvironment has been demonstrated to be of prognostic value in various 
      cancers. In this systematic review and meta-analysis, we investigated the 
      prognostic value of TIL in laryngeal squamous cell carcinoma (LSCC). We performed 
      a systematic search in PubMed for publications that investigated the prognostic 
      value of TIL in LSCC. A meta-analysis was performed including all studies 
      assessing the association between TIL counts in hematoxylin-eosin (HE)-stained 
      sections, for CD8+ and/or CD3+/CD4+ TIL and overall survival (OS) or disease-free 
      survival (DFS). The pooled meta-analysis showed a favorable prognostic role for 
      stromal TIL in HE sections for OS (HR 0.57, 95% CI 0.36-0.91, p = 0.02), and for 
      DFS (HR 0.56, 95% CI 0.34-0.94, p = 0.03). High CD8+ TIL were associated with a 
      prolonged OS (HR 0.62, 95% CI 0.4-0.97, p = 0.04) and DFS (HR 0.73, 95% CI 
      0.34-0.94, p = 0.002). High CD3+/CD4+ TIL demonstrated improved OS (HR 0.32, 95% 
      CI 0.16-0.9, p = 0.03) and DFS (HR 0.23, 95% CI 0.10-0.53, p = 0.0005). This 
      meta-analysis confirmed the favorable prognostic significance of TIL in LSCC. 
      High stromal TIL evaluated in HE sections and intra-tumoral and stromal CD3+, 
      CD4+ and/or CD8+ TIL might predict a better clinical outcome.
FAU - Rodrigo, Juan P
AU  - Rodrigo JP
AUID- ORCID: 0000-0003-3063-0890
AD  - Department of Otolaryngology, Hospital Universitario Central de 
      Asturias-Instituto de Salud del Principado de Asturias (ISPA), 33011 Oviedo, 
      Spain.
AD  - IUOPA-University of Oviedo, 33006 Oviedo, Spain.
AD  - CIBERONC, Instituto de Salud Carlos III, 28029 Madrid, Spain.
FAU - Sanchez-Canteli, Mario
AU  - Sanchez-Canteli M
AUID- ORCID: 0000-0003-0343-0041
AD  - Department of Otolaryngology, Hospital Universitario Central de 
      Asturias-Instituto de Salud del Principado de Asturias (ISPA), 33011 Oviedo, 
      Spain.
AD  - IUOPA-University of Oviedo, 33006 Oviedo, Spain.
AD  - CIBERONC, Instituto de Salud Carlos III, 28029 Madrid, Spain.
FAU - Lopez, Fernando
AU  - Lopez F
AUID- ORCID: 0000-0001-7019-9746
AD  - Department of Otolaryngology, Hospital Universitario Central de 
      Asturias-Instituto de Salud del Principado de Asturias (ISPA), 33011 Oviedo, 
      Spain.
AD  - IUOPA-University of Oviedo, 33006 Oviedo, Spain.
AD  - CIBERONC, Instituto de Salud Carlos III, 28029 Madrid, Spain.
FAU - Wolf, Gregory T
AU  - Wolf GT
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Michigan Health 
      System, Ann Arbor, MI 48109, USA.
FAU - Hernandez-Prera, Juan C
AU  - Hernandez-Prera JC
AD  - Department of Pathology, Moffitt Cancer Center, Tampa, FL 33612, USA.
FAU - Williams, Michelle D
AU  - Williams MD
AD  - Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 
      Houston, TX 77030, USA.
FAU - Willems, Stefan M
AU  - Willems SM
AD  - Department of Pathology, University Medical Center Groningen, 9713 GZ Groningen, 
      The Netherlands.
FAU - Franchi, Alessandro
AU  - Franchi A
AUID- ORCID: 0000-0002-1332-5838
AD  - Department of Translational Research, School of Medicine, University of Pisa, 
      56126 Pisa, Italy.
FAU - Coca-Pelaz, Andres
AU  - Coca-Pelaz A
AD  - Department of Otolaryngology, Hospital Universitario Central de 
      Asturias-Instituto de Salud del Principado de Asturias (ISPA), 33011 Oviedo, 
      Spain.
AD  - IUOPA-University of Oviedo, 33006 Oviedo, Spain.
AD  - CIBERONC, Instituto de Salud Carlos III, 28029 Madrid, Spain.
FAU - Ferlito, Alfio
AU  - Ferlito A
AD  - Coordinator of the International Head and Neck Scientific Group, 35125 Padua, 
      Italy.
LA  - eng
GR  - CB16/12/00390/Centro de Investigacion Biomedica en Red de Cancer/
GR  - PI19/00560/Instituto de Salud Carlos III/
PT  - Journal Article
PT  - Review
DEP - 20210428
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC8145951
OTO - NOTNLM
OT  - larynx
OT  - prognosis
OT  - squamous cell carcinoma
OT  - tumor-infiltrating lymphocytes
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2021/05/01 06:00
MHDA- 2021/05/01 06:01
PMCR- 2021/04/28
CRDT- 2021/04/30 01:31
PHST- 2021/03/14 00:00 [received]
PHST- 2021/04/18 00:00 [revised]
PHST- 2021/04/26 00:00 [accepted]
PHST- 2021/04/30 01:31 [entrez]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/05/01 06:01 [medline]
PHST- 2021/04/28 00:00 [pmc-release]
AID - biomedicines9050486 [pii]
AID - biomedicines-09-00486 [pii]
AID - 10.3390/biomedicines9050486 [doi]
PST - epublish
SO  - Biomedicines. 2021 Apr 28;9(5):486. doi: 10.3390/biomedicines9050486.