PMID- 33926722 OWN - NLM STAT- MEDLINE DCOM- 20211005 LR - 20211005 IS - 1556-5653 (Electronic) IS - 0015-0282 (Linking) VI - 116 IP - 3 DP - 2021 Sep TI - International Committee for Monitoring Assisted Reproductive Technologies (ICMART): world report on assisted reproductive technologies, 2013. PG - 741-756 LID - S0015-0282(21)00244-2 [pii] LID - 10.1016/j.fertnstert.2021.03.039 [doi] AB - OBJECTIVE: To report the utilization, effectiveness, and safety of practices in assisted reproductive technology (ART) globally in 2013 and assess global trends over time. DESIGN: Retrospective, cross-sectional survey on the utilization, effectiveness, and safety of ART procedures performed globally during 2013. SETTING: Seventy-five countries and 2,639 ART clinics. PATIENT(S): Women and men undergoing ART procedures. INTERVENTION(S): All ART. MAIN OUTCOME MEASURE(S): The ART cycles and outcomes on country-by-country, regional, and global levels. Aggregate country data were processed and analyzed based on methods developed by the International Committee for Monitoring Assisted Reproductive Technology (ICMART). RESULT(S): A total of 1,858,500 ART cycles were conducted for the treatment year 2013 across 2,639 clinics in 75 participating countries with a global participation rate of 73.6%. Reported and estimated data suggest 1,160,474 embryo transfers (ETs) were performed resulting in >344,317 babies. From 2012 to 2013, the number of reported aspiration and frozen ET cycles increased by 3% and 16.4%, respectively. The proportion of women aged >40 years undergoing nondonor ART increased from 25.2% in 2012 to 26.3% in 2013. As a percentage of nondonor aspiration cycles, intracytoplasmic sperm injection (ICSI) was similar to results for 2012. The in vitro fertilization (IVF)/ICSI combined delivery rates per fresh aspiration and frozen ET cycles were 24.2% and 22.8%, respectively. In fresh nondonor cycles, single ET increased from 33.7% in 2012 to 36.5% in 2013, whereas the average number of transferred embryos was 1.81-again with wide country variation. The rate of twin deliveries after fresh nondonor transfers was 17.9%; the triplet rate was 0.7%. In frozen ET cycles performed in 2013, single ET was used in 57.6%, with an average of 1.49 embryos transferred and twin and triplet rates of 10.8% and 0.4%, respectively. The cumulative delivery rate per aspiration was 30.4%, similar to that in 2012. Perinatal mortality rate per 1,000 births was 22.2% after fresh IVF/ICSI and 16.8% after frozen ET. The data presented depended on the quality and completeness of the data submitted by individual countries. This report covers approximately two-thirds of world ART activity. Continued efforts to improve the quality and consistency of reporting ART data by registries are still needed. CONCLUSION(S): Reported ART cycles, effectiveness, and safety increased between 2012 and 2013 with adoption of a better method for estimating unreported cycles. CI - Copyright (c) 2021 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. FAU - Banker, Manish AU - Banker M AD - Nova IVF Fertility, Ahmedabad, Gujarat, India. Electronic address: manishbanker1@gmail.com. FAU - Dyer, Silke AU - Dyer S AD - Department of Obstetrics and Gynaecology, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. FAU - Chambers, Georgina M AU - Chambers GM AD - National Perinatal Epidemiology and Statistics Unit, Centre for Big Data Research in Health, School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia. FAU - Ishihara, Osamu AU - Ishihara O AD - Department of Obstetrics and Gynaecology, Saitama Medical University, Moroyama, Japan. FAU - Kupka, Markus AU - Kupka M AD - Fertility Center - Gynaekologicum, Hamburg, Germany. FAU - de Mouzon, Jacques AU - de Mouzon J AD - Epidemiology, Research and Development, Paris, France. FAU - Zegers-Hochschild, Fernando AU - Zegers-Hochschild F AD - Clinica las Condes and Program of Ethics and Public Policies in Human Reproduction, University Diego Portales, Santiago, Chile. FAU - Adamson, G David AU - Adamson GD AD - Equal3 Fertility, Cupertino; Stanford University School of Medicine, Palo Alto; and University of California School of Medicine, San Francisco, California. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210427 PL - United States TA - Fertil Steril JT - Fertility and sterility JID - 0372772 SB - IM CIN - Fertil Steril. 2021 Sep;116(3):662-663. PMID: 34462099 MH - Cross-Sectional Studies MH - Female MH - Fertility MH - Global Health/*trends MH - Healthcare Disparities/trends MH - Humans MH - Infertility, Female/epidemiology/physiopathology/*therapy MH - Infertility, Male/epidemiology/physiopathology/*therapy MH - Live Birth MH - Male MH - Pregnancy MH - Pregnancy Rate/trends MH - Reproductive Medicine/*trends MH - Reproductive Techniques, Assisted/*trends MH - Retrospective Studies MH - Time Factors MH - Treatment Outcome OTO - NOTNLM OT - Assisted reproductive technology OT - ICMART OT - IVF/ICSI outcome OT - cumulative live birth rate OT - frozen embryo transfer OT - registry EDAT- 2021/05/01 06:00 MHDA- 2021/10/06 06:00 CRDT- 2021/04/30 05:52 PHST- 2021/01/09 00:00 [received] PHST- 2021/03/08 00:00 [revised] PHST- 2021/03/24 00:00 [accepted] PHST- 2021/05/01 06:00 [pubmed] PHST- 2021/10/06 06:00 [medline] PHST- 2021/04/30 05:52 [entrez] AID - S0015-0282(21)00244-2 [pii] AID - 10.1016/j.fertnstert.2021.03.039 [doi] PST - ppublish SO - Fertil Steril. 2021 Sep;116(3):741-756. doi: 10.1016/j.fertnstert.2021.03.039. Epub 2021 Apr 27.