PMID- 3392769
OWN - NLM
STAT- MEDLINE
DCOM- 19880819
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 62
IP  - 8
DP  - 1988 Aug
TI  - Purified envelope glycoproteins from human immunodeficiency virus type 1 variants 
      induce individual, type-specific neutralizing antibodies.
PG  - 2622-8
AB  - Repeated immunizations of goats, horses, or chimpanzees with envelope 
      glycoprotein gp120 isolated from human immunodeficiency virus type 1 (HIV-1) 
      resulted in type-specific neutralizing-antibody responses, which began to decay 
      approximately 20 days following the administration of antigen. This was true 
      repeatedly for serum samples from animals hyperimmunized with gp120s from either 
      the HTLV-IIIB (IIIB) or the envelope-divergent HTLV-IIIRF (RF) HIV-1 isolates. 
      Animals previously immunized with the IIIB gp120 were then inoculated with 
      purified RF gp120. The first response in these animals was an anamnestic 
      resurgence of neutralizing antibody to IIIB without detectable neutralizing 
      antibody for RF. However, with later RF gp120 boosts, the IIIB 
      neutralizing-antibody titers fell and an RF type-specific neutralizing-antibody 
      response developed. When assessed with other HIV-1 variants, no group-specific 
      neutralizing antibody was seen in any of the vaccination protocols evaluated. 
      These results will pose real obstacles in the development of an effective vaccine 
      for HIV.
FAU - Nara, P L
AU  - Nara PL
AD  - Office of the Director, National Cancer Institute-Frederick Cancer Research 
      Facility, Maryland 21701.
FAU - Robey, W G
AU  - Robey WG
FAU - Pyle, S W
AU  - Pyle SW
FAU - Hatch, W C
AU  - Hatch WC
FAU - Dunlop, N M
AU  - Dunlop NM
FAU - Bess, J W Jr
AU  - Bess JW Jr
FAU - Kelliher, J C
AU  - Kelliher JC
FAU - Arthur, L O
AU  - Arthur LO
FAU - Fischinger, P J
AU  - Fischinger PJ
LA  - eng
GR  - N01-CO-74102/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/*immunology
MH  - Antigens, Viral/*immunology
MH  - Dose-Response Relationship, Immunologic
MH  - Goats
MH  - HIV/*immunology
MH  - Horses
MH  - Membrane Glycoproteins/immunology
MH  - Neutralization Tests
MH  - Pan troglodytes
MH  - Time Factors
MH  - Vaccination
MH  - Viral Envelope Proteins/*immunology
PMC - PMC253692
EDAT- 1988/08/01 00:00
MHDA- 2001/03/28 10:01
PMCR- 1988/08/01
CRDT- 1988/08/01 00:00
PHST- 1988/08/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1988/08/01 00:00 [entrez]
PHST- 1988/08/01 00:00 [pmc-release]
AID - 10.1128/JVI.62.8.2622-2628.1988 [doi]
PST - ppublish
SO  - J Virol. 1988 Aug;62(8):2622-8. doi: 10.1128/JVI.62.8.2622-2628.1988.