PMID- 33928434 OWN - NLM STAT- MEDLINE DCOM- 20220204 LR - 20230206 IS - 1432-1440 (Electronic) IS - 0946-2716 (Linking) VI - 99 IP - 7 DP - 2021 Jul TI - The mutual interplay of redox signaling and connexins. PG - 933-941 LID - 10.1007/s00109-021-02084-0 [doi] AB - Connexins (Cxs) are ubiquitous transmembrane proteins that possess both channel function (e.g., formations of gap junction and hemichannel) and non-channel properties (e.g., gene transcription and protein-protein interaction). Several factors have been identified to play a role in the regulation of Cxs, which include those acting intracellularly, as redox potential, pH, intramolecular interactions, and post-translational modifications (e.g., phosphorylation, S-nitrosylation) as well as those acting extracellularly, such as Ca(2+) and Mg(2+). The relationship between redox signaling and Cxs attracts considerable attention in recent years. There is ample evidence showing that redox signaling molecules (e.g., hydrogen peroxide (H(2)O(2)), nitric oxide (NO)) affect Cxs-based channel function while the opening of Cx channels also triggers the transfer of various redox-related metabolites (e.g., reactive oxygen species, glutathione, nicotinamide adenine dinucleotide, and NO). On the basis of these evidences, we propose the existence of redox-Cxs crosstalk. In this review, we briefly discuss the interaction between redox signaling and Cxs and the implications of the intersection in disease pathology and future therapeutic interventions. FAU - Zhang, Kai AU - Zhang K AD - Department of Clinical Pharmacology, Xiangya Hospital and Institute of Clinical Pharmacology, Central South University, 87 Xiangya Road, Changsha, 410008, People's Republic of China. AD - Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, 110 Xiangya Road, Changsha, 410078, People's Republic of China. AD - Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, 410078, People's Republic of China. AD - National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. FAU - Guan, Qi-Wen AU - Guan QW AD - Department of Clinical Pharmacology, Xiangya Hospital and Institute of Clinical Pharmacology, Central South University, 87 Xiangya Road, Changsha, 410008, People's Republic of China. AD - Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, 110 Xiangya Road, Changsha, 410078, People's Republic of China. AD - Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, 410078, People's Republic of China. AD - National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. FAU - Zhou, Xin-Yu AU - Zhou XY AD - Department of Neurology, Lianyungang Hospital affiliated with Xuzhou Medical College, Tongguan Road, 182, Lianyungang, Jiangsu, People's Republic of China. FAU - Xia, Qin-Xuan AU - Xia QX AD - Department of Clinical Pharmacology, Xiangya Hospital and Institute of Clinical Pharmacology, Central South University, 87 Xiangya Road, Changsha, 410008, People's Republic of China. AD - Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, 110 Xiangya Road, Changsha, 410078, People's Republic of China. AD - Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, 410078, People's Republic of China. AD - National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. FAU - Yin, Xi-Xi AU - Yin XX AD - Department of Pediatrics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. FAU - Zhou, Hong-Hao AU - Zhou HH AD - Department of Clinical Pharmacology, Xiangya Hospital and Institute of Clinical Pharmacology, Central South University, 87 Xiangya Road, Changsha, 410008, People's Republic of China. AD - Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, 110 Xiangya Road, Changsha, 410078, People's Republic of China. AD - Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, 410078, People's Republic of China. AD - National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. FAU - Mao, Xiao-Yuan AU - Mao XY AUID- ORCID: 0000-0002-5149-1204 AD - Department of Clinical Pharmacology, Xiangya Hospital and Institute of Clinical Pharmacology, Central South University, 87 Xiangya Road, Changsha, 410008, People's Republic of China. xiaoyuanm@csu.edu.cn. AD - Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, 110 Xiangya Road, Changsha, 410078, People's Republic of China. xiaoyuanm@csu.edu.cn. AD - Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, 410078, People's Republic of China. xiaoyuanm@csu.edu.cn. AD - National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008, Hunan, People's Republic of China. xiaoyuanm@csu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20210429 PL - Germany TA - J Mol Med (Berl) JT - Journal of molecular medicine (Berlin, Germany) JID - 9504370 RN - 0 (Connexins) SB - IM MH - Animals MH - Connexins/*metabolism MH - Humans MH - Oxidation-Reduction MH - Signal Transduction OTO - NOTNLM OT - Connexin OT - Disease pathology OT - Mutual interplay OT - Redox OT - Therapy EDAT- 2021/05/01 06:00 MHDA- 2022/02/05 06:00 CRDT- 2021/04/30 07:04 PHST- 2020/12/18 00:00 [received] PHST- 2021/04/26 00:00 [accepted] PHST- 2021/04/20 00:00 [revised] PHST- 2021/05/01 06:00 [pubmed] PHST- 2022/02/05 06:00 [medline] PHST- 2021/04/30 07:04 [entrez] AID - 10.1007/s00109-021-02084-0 [pii] AID - 10.1007/s00109-021-02084-0 [doi] PST - ppublish SO - J Mol Med (Berl). 2021 Jul;99(7):933-941. doi: 10.1007/s00109-021-02084-0. Epub 2021 Apr 29.