PMID- 33929277
OWN - NLM
STAT- MEDLINE
DCOM- 20220706
LR  - 20220718
IS  - 1532-4311 (Electronic)
IS  - 0882-0139 (Linking)
VI  - 51
IP  - 5
DP  - 2022 Jul
TI  - Influence of HLA Class II Alleles and DRB1-DQB1 Haplotypes on Rheumatoid 
      Arthritis Susceptibility and Autoantibody Status in the Chinese Han Population.
PG  - 1198-1210
LID - 10.1080/08820139.2021.1918708 [doi]
AB  - Human leukocyte antigen (HLA) class II alleles are considered to play a key role 
      in the progress of rheumatoid arthritis (RA). This study was carried out to 
      investigate the presence of HLA class II alleles and their influence on disease 
      risk and autoantibody status in Chinese Han patients with RA. Here, HLA-DRB1, 
      DQB1 and DPB1 genotyping was performed in 125 RA patients and 120 healthy 
      controls by using the next-generation sequencing (NGS). Strong positive 
      associations were shown between high-resolution typed HLA-DRB1*04:05:01, 
      DRB1*10:01:01, DQB1*04:01:01, DPB1*02:01:02 and RA patients. Moreover, the 
      haplotypes HLA-DRB1*04:05:01~ DQB1*04:01:01 and HLA-DRB1*10:01:01~ DQB1*05:01:01 
      were found to be more frequent in RA populations than in healthy controls. These 
      possible susceptible HLA alleles (HLA-DRB1*04:05:01, DRB1*10:01:01, DQB1*04:01:01 
      and DPB1*02:01:02) also showed higher frequencies in seropositive RA patients as 
      compared to normal controls. The present study provided evidence that alleles 
      HLA-DRB1*04:05:01, DRB1*10:01:01, DQB1*04:01:01 and DPB1*02:01:02 constituted RA 
      risk alleles, and haplotypes HLA-DRB1*04:05:01~ DQB1*04:01:01, 
      HLA-DRB1*10:01:01~ DQB1*05:01:01 also showed prevalence in Chinese Han patients 
      with RA. Serological results preliminary demonstrated patients carrying RA-risk 
      HLA alleles might elevate the serum level of anti-citrullinated protein 
      antibodies and rheumatoid factor and affect RA progression.
FAU - Wan, Xin
AU  - Wan X
AUID- ORCID: 0000-0001-5988-3328
AD  - Department of Medical Laboratory Center, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Medical Laboratory Center, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, China.
FAU - Jin, Peipei
AU  - Jin P
AD  - Department of Medical Laboratory Center, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, China.
FAU - Zhang, Ju
AU  - Zhang J
AD  - Department of Medical Laboratory Center, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, China.
FAU - Liu, Liu
AU  - Liu L
AD  - Department of Medical Laboratory Center, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, China.
FAU - Wang, Zhangfei
AU  - Wang Z
AD  - Department of Medical Laboratory Center, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, China.
FAU - Hu, Yue
AU  - Hu Y
AD  - Department of Prenatal Diagnosis Center, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei, China.
LA  - eng
PT  - Journal Article
DEP - 20210430
PL  - England
TA  - Immunol Invest
JT  - Immunological investigations
JID - 8504629
RN  - 0 (Anti-Citrullinated Protein Antibodies)
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DPB1*02:01:04 antigen)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04:05 antigen)
SB  - IM
MH  - Alleles
MH  - Anti-Citrullinated Protein Antibodies/blood/genetics/immunology
MH  - *Arthritis, Rheumatoid/blood/epidemiology/genetics/immunology
MH  - Autoantibodies/blood/genetics/immunology
MH  - China/epidemiology
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/genetics
MH  - *HLA-DP beta-Chains/genetics/immunology
MH  - *HLA-DQ beta-Chains/genetics/immunology
MH  - *HLA-DRB1 Chains/genetics/immunology
MH  - Haplotypes
MH  - Humans
MH  - Risk
OTO - NOTNLM
OT  - HLA class II alleles
OT  - HLA-DRB1~DQB1 haplotypes
OT  - Rheumatoid arthritis
OT  - autoantibodies
EDAT- 2021/05/01 06:00
MHDA- 2022/07/07 06:00
CRDT- 2021/04/30 12:13
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2022/07/07 06:00 [medline]
PHST- 2021/04/30 12:13 [entrez]
AID - 10.1080/08820139.2021.1918708 [doi]
PST - ppublish
SO  - Immunol Invest. 2022 Jul;51(5):1198-1210. doi: 10.1080/08820139.2021.1918708. 
      Epub 2021 Apr 30.