PMID- 33930247
OWN - NLM
STAT- MEDLINE
DCOM- 20210723
LR  - 20220531
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 75
IP  - 8
DP  - 2021 Aug
TI  - Interaction between the dietary indices and PPAR-gamma Pro12Ala gene variants on 
      cardiovascular risk factors in patients with type 2 diabetes mellitus.
PG  - e14307
LID - 10.1111/ijcp.14307 [doi]
AB  - AIMS: We investigated the interaction between peroxisome proliferator-activated 
      receptor gamma (PPAR-gamma) Pro12Ala polymorphism and healthy eating index (HEI), 
      Dietary Quality Index-International (DQI-I), and dietary phytochemical index 
      (DPI) on cardiovascular disease (CVD) risk factors in patients with type 2 
      diabetes mellitus (T2DM). METHODS: This cross-sectional study was conducted on 
      393 diabetic patients. PPAR-gamma Pro12Ala was genotyped by the PCR-RFLP method. 
      Biochemical markers including total cholesterol (TC), low-density lipoprotein 
      (LDL), high-density lipoprotein (HDL), triglyceride (TG), superoxide dismutase 
      (SOD), C-reactive protein (CRP), total antioxidant capacity (TAC), pentraxin-3 
      (PTX3), isoprostaneF2alpha (PGF2alpha). Interleukin 18 (IL18), leptin, and ghrelin were 
      measured by standard protocol. Food-frequency questionnaires (FFQ) were used for 
      dietary indices (DQI-I, DPI, HEI) calculation. RESULTS: Homozygous carriers of 
      the rs1801282 C allele showed higher leptin compared G allele carriers 
      (P = .015). The rs1801282-DQI-I interactions were significant on waist 
      circumference (WC) (P = .019). Thus, C-allele carriers in the higher tertile of 
      DQI-I had higher WC compared with GG homozygous. Further, an interaction was 
      observed between PPAR rs1801282 polymorphism and DQI-I on serum IL-18 level 
      (P = .032). Besides, a significant rs1801282-DPI interaction was shown on HDL 
      concentration (P = .041), G allele carriers who were in the highest tertile of 
      DPI, had lower HDL. Moreover, there were significant rs1801282-HEI interactions 
      on serum leptin (P = .021). Individuals with (CC, CG) genotypes in the higher 
      tertile of HEI, had lower leptin concentration. CONCLUSION: Higher dietary 
      indices (DQI-I, DPI, HEI) may affect the relationship between PPAR-gamma Pro12Ala 
      polymorphism and WC, ghrelin, leptin, HDL, and IL-18 concentration in patients 
      with T2DM.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Abaj, Faezeh
AU  - Abaj F
AUID- ORCID: 0000-0002-7841-2000
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences (TUMS), Tehran, Iran.
FAU - Sotoudeh, Gity
AU  - Sotoudeh G
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences (TUMS), Tehran, Iran.
FAU - Karimi, Elmira
AU  - Karimi E
AUID- ORCID: 0000-0001-7871-2313
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences (TUMS), Tehran, Iran.
FAU - Rafiee, Masoumeh
AU  - Rafiee M
AD  - Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan 
      University of Medical Sciences (IUMS), Isfahan, Iran.
FAU - Koohdani, Fariba
AU  - Koohdani F
AD  - Department of Cellular, Molecular Nutrition, School of Nutritional Sciences and 
      Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
LA  - eng
GR  - 15061/Tehran University of Medical Sciences and Health Services/
PT  - Journal Article
DEP - 20210517
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (PPAR gamma)
RN  - 0 (PPARG protein, human)
SB  - IM
MH  - *Cardiovascular Diseases/genetics
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Genotype
MH  - Heart Disease Risk Factors
MH  - Humans
MH  - PPAR gamma
MH  - Risk Factors
EDAT- 2021/05/01 06:00
MHDA- 2021/07/24 06:00
CRDT- 2021/04/30 17:48
PHST- 2020/11/30 00:00 [received]
PHST- 2021/04/27 00:00 [accepted]
PHST- 2021/05/01 06:00 [pubmed]
PHST- 2021/07/24 06:00 [medline]
PHST- 2021/04/30 17:48 [entrez]
AID - 10.1111/ijcp.14307 [doi]
PST - ppublish
SO  - Int J Clin Pract. 2021 Aug;75(8):e14307. doi: 10.1111/ijcp.14307. Epub 2021 May 
      17.