PMID- 33931567
OWN - NLM
STAT- Publisher
LR  - 20240320
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 372
IP  - 6549
DP  - 2021 Apr 30
TI  - Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first 
      vaccine dose.
PG  - 1418-23
LID - eabh1282 [pii]
LID - 10.1126/science.abh1282 [doi]
AB  - SARS-CoV-2 vaccine rollout has coincided with the spread of variants of concern. 
      We investigated if single dose vaccination, with or without prior infection, 
      confers cross protective immunity to variants. We analyzed T and B cell responses 
      after first dose vaccination with the Pfizer/BioNTech mRNA vaccine BNT162b2 in 
      healthcare workers (HCW) followed longitudinally, with or without prior 
      Wuhan-Hu-1 SARS-CoV-2 infection. After one dose, individuals with prior infection 
      showed enhanced T cell immunity, antibody secreting memory B cell response to 
      spike and neutralizing antibodies effective against B.1.1.7 and B.1.351. By 
      comparison, HCW receiving one vaccine dose without prior infection showed reduced 
      immunity against variants. B.1.1.7 and B.1.351 spike mutations resulted in 
      increased, abrogated or unchanged T cell responses depending on human leukocyte 
      antigen (HLA) polymorphisms. Single dose vaccination with BNT162b2 in the context 
      of prior infection with a heterologous variant substantially enhances 
      neutralizing antibody responses against variants.
CI  - Copyright (c) 2021 The Authors, some rights reserved; exclusive licensee American 
      Association for the Advancement of Science. No claim to original U.S. Government 
      Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
FAU - Reynolds, Catherine J
AU  - Reynolds CJ
AUID- ORCID: 0000-0002-1371-653X
AD  - Department of Infectious Disease, Imperial College London, London, UK.
FAU - Pade, Corinna
AU  - Pade C
AUID- ORCID: 0000-0003-0626-2346
AD  - Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen 
      Mary University of London, London, UK.
FAU - Gibbons, Joseph M
AU  - Gibbons JM
AUID- ORCID: 0000-0002-7238-2381
AD  - Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen 
      Mary University of London, London, UK.
FAU - Butler, David K
AU  - Butler DK
AUID- ORCID: 0000-0003-1882-8159
AD  - Department of Infectious Disease, Imperial College London, London, UK.
FAU - Otter, Ashley D
AU  - Otter AD
AUID- ORCID: 0000-0002-8317-9194
AD  - National Infection Service, Public Health England, Porton Down, UK.
FAU - Menacho, Katia
AU  - Menacho K
AUID- ORCID: 0000-0001-5183-5655
AD  - St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
FAU - Fontana, Marianna
AU  - Fontana M
AUID- ORCID: 0000-0002-9233-9831
AD  - Royal Free London NHS Foundation Trust, London, UK.
AD  - Division of Medicine, University College London, London, UK.
FAU - Smit, Angelique
AU  - Smit A
AUID- ORCID: 0000-0002-2144-1249
AD  - Royal Free London NHS Foundation Trust, London, UK.
FAU - Sackville-West, Jane E
AU  - Sackville-West JE
AUID- ORCID: 0000-0001-7724-8125
AD  - James Wigg Practice, Kentish Town, London, UK.
FAU - Cutino-Moguel, Teresa
AU  - Cutino-Moguel T
AUID- ORCID: 0000-0002-1726-4278
AD  - St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
FAU - Maini, Mala K
AU  - Maini MK
AUID- ORCID: 0000-0001-6384-1462
AD  - Division of Infection and Immunity, University College London, London, UK.
FAU - Chain, Benjamin
AU  - Chain B
AUID- ORCID: 0000-0002-7417-3970
AD  - Division of Infection and Immunity, University College London, London, UK.
FAU - Noursadeghi, Mahdad
AU  - Noursadeghi M
AUID- ORCID: 0000-0002-4774-0853
AD  - Division of Infection and Immunity, University College London, London, UK.
CN  - UK COVIDsortium Immune Correlates Network
FAU - Brooks, Tim
AU  - Brooks T
AUID- ORCID: 0000-0002-3783-1284
AD  - National Infection Service, Public Health England, Porton Down, UK.
FAU - Semper, Amanda
AU  - Semper A
AUID- ORCID: 0000-0003-3656-1363
AD  - National Infection Service, Public Health England, Porton Down, UK.
FAU - Manisty, Charlotte
AU  - Manisty C
AUID- ORCID: 0000-0003-0245-7090
AD  - St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
AD  - Institute of Cardiovascular Science, University College London, London, UK.
FAU - Treibel, Thomas A
AU  - Treibel TA
AUID- ORCID: 0000-0003-1560-7414
AD  - St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
AD  - Institute of Cardiovascular Science, University College London, London, UK.
FAU - Moon, James C
AU  - Moon JC
AUID- ORCID: 0000-0001-8071-1491
AD  - St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
AD  - Institute of Cardiovascular Science, University College London, London, UK.
CN  - UK COVIDsortium Investigators
FAU - Valdes, Ana M
AU  - Valdes AM
AUID- ORCID: 0000-0003-1141-4471
AD  - Academic Rheumatology, Clinical Sciences, Nottingham City Hospital, Nottingham, 
      UK.
AD  - NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS 
      Trust and University of Nottingham, Nottingham, UK.
FAU - McKnight, Aine
AU  - McKnight A
AUID- ORCID: 0000-0002-8113-817X
AD  - Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen 
      Mary University of London, London, UK.
FAU - Altmann, Daniel M
AU  - Altmann DM
AUID- ORCID: 0000-0002-2436-6192
AD  - Department of Immunology and Inflammation, Imperial College London, London, UK.
FAU - Boyton, Rosemary
AU  - Boyton R
AUID- ORCID: 0000-0002-5608-0797
AD  - Department of Infectious Disease, Imperial College London, London, UK. 
      r.boyton@imperial.ac.uk.
AD  - Lung Division, Royal Brompton and Harefield Hospitals, London, UK.
LA  - eng
GR  - MR/V027883/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/V028448/1/MRC_/Medical Research Council/United Kingdom
GR  - MC_PC_20060/MRC_/Medical Research Council/United Kingdom
GR  - MR/S019553/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/R02622X/1/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - MR/W020610/1/MRC_/Medical Research Council/United Kingdom
GR  - MRF_MRF-044-0001-RG-SWADL/MRF/MRF/United Kingdom
GR  - MR/V036939/1/MRC_/Medical Research Council/United Kingdom
GR  - FS/18/21/33447/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
DEP - 20210430
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
CIN - MMW Fortschr Med. 2021 May;163(9):21. PMID: 33961240
PMC - PMC8168614
FIR - Abbass, Hakam
IR  - Abbass H
FIR - Alfarih, Mashael
IR  - Alfarih M
FIR - Alldis, Zoe
IR  - Alldis Z
FIR - Altmann, Daniel M
IR  - Altmann DM
FIR - Amin, Oliver E
IR  - Amin OE
FIR - Andiapen, Mervyn
IR  - Andiapen M
FIR - Artico, Jessica
IR  - Artico J
FIR - Augusto, Joao B
IR  - Augusto JB
FIR - Baca, Georgina L
IR  - Baca GL
FIR - Bailey, Sasha N L
IR  - Bailey SNL
FIR - Bhuva, Anish N
IR  - Bhuva AN
FIR - Boulter, Alex
IR  - Boulter A
FIR - Bowles, Ruth
IR  - Bowles R
FIR - Boyton, Rosemary J
IR  - Boyton RJ
FIR - Bracken, Olivia V
IR  - Bracken OV
FIR - O'Brien, Ben
IR  - O'Brien B
FIR - Brooks, Tim
IR  - Brooks T
FIR - Bullock, Natalie
IR  - Bullock N
FIR - Butler, David K
IR  - Butler DK
FIR - Captur, Gabriella
IR  - Captur G
FIR - Champion, Nicola
IR  - Champion N
FIR - Chan, Carmen
IR  - Chan C
FIR - Chandran, Aneesh
IR  - Chandran A
FIR - Couto de Sousa, Jorge
IR  - Couto de Sousa J
FIR - Couto-Parada, Xose
IR  - Couto-Parada X
FIR - Cutino-Moguel, Teresa
IR  - Cutino-Moguel T
FIR - Davies, Rhodri H
IR  - Davies RH
FIR - Douglas, Brooke
IR  - Douglas B
FIR - Di Genova, Cecilia
IR  - Di Genova C
FIR - Dieobi-Anene, Keenan
IR  - Dieobi-Anene K
FIR - Diniz, Mariana O
IR  - Diniz MO
FIR - Ellis, Anaya
IR  - Ellis A
FIR - Feehan, Karen
IR  - Feehan K
FIR - Finlay, Malcolm
IR  - Finlay M
FIR - Fontana, Marianna
IR  - Fontana M
FIR - Forooghi, Nasim
IR  - Forooghi N
FIR - Gibbons, Joseph M
IR  - Gibbons JM
FIR - Gilroy, Derek
IR  - Gilroy D
FIR - Hamblin, Matt
IR  - Hamblin M
FIR - Harker, Gabrielle
IR  - Harker G
FIR - Hewson, Jacqueline
IR  - Hewson J
FIR - Hickling, Lauren M
IR  - Hickling LM
FIR - Hingorani, Aroon D
IR  - Hingorani AD
FIR - Howes, Lee
IR  - Howes L
FIR - Itua, Ivie
IR  - Itua I
FIR - Jardim, Victor
IR  - Jardim V
FIR - Lee, Wing-Yiu Jason
IR  - Lee WJ
FIR - Jensen, Melaniepetra
IR  - Jensen M
FIR - Jones, Jessica
IR  - Jones J
FIR - Jones, Meleri
IR  - Jones M
FIR - Joy, George
IR  - Joy G
FIR - Kapil, Vikas
IR  - Kapil V
FIR - Kurdi, Hibba
IR  - Kurdi H
FIR - Lambourne, Jonathan
IR  - Lambourne J
FIR - Lin, Kai-Min
IR  - Lin KM
FIR - Louth, Sarah
IR  - Louth S
FIR - Maini, Mala K
IR  - Maini MK
FIR - Mandadapu, Vineela
IR  - Mandadapu V
FIR - Manisty, Charlotte
IR  - Manisty C
FIR - McKnight, Aine
IR  - McKnight A
FIR - Menacho, Katia
IR  - Menacho K
FIR - Mfuko, Celina
IR  - Mfuko C
FIR - Mitchelmore, Oliver
IR  - Mitchelmore O
FIR - Moon, Christopher
IR  - Moon C
FIR - Moon, James C
IR  - Moon JC
FIR - Murray, Sam M
IR  - Murray SM
FIR - Noursadeghi, Mahdad
IR  - Noursadeghi M
FIR - Otter, Ashley
IR  - Otter A
FIR - Pade, Corinna
IR  - Pade C
FIR - Palma, Susana
IR  - Palma S
FIR - Parker, Ruth
IR  - Parker R
FIR - Patel, Kush
IR  - Patel K
FIR - Pawarova, Babita
IR  - Pawarova B
FIR - Petersen, Steffen E
IR  - Petersen SE
FIR - Piniera, Brian
IR  - Piniera B
FIR - Pieper, Franziska P
IR  - Pieper FP
FIR - Rannigan, Lisa
IR  - Rannigan L
FIR - Rapala, Alicja
IR  - Rapala A
FIR - Reynolds, Catherine J
IR  - Reynolds CJ
FIR - Richards, Amy
IR  - Richards A
FIR - Robathan, Matthew
IR  - Robathan M
FIR - Rosenheim, Joshua
IR  - Rosenheim J
FIR - Sambile, Genine
IR  - Sambile G
FIR - Schmidt, Nathalie M
IR  - Schmidt NM
FIR - Semper, Amanda
IR  - Semper A
FIR - Seraphim, Andreas
IR  - Seraphim A
FIR - Simion, Mihaela
IR  - Simion M
FIR - Smit, Angelique
IR  - Smit A
FIR - Sugimoto, Michelle
IR  - Sugimoto M
FIR - Swadling, Leo
IR  - Swadling L
FIR - Taylor, Stephen
IR  - Taylor S
FIR - Temperton, Nigel
IR  - Temperton N
FIR - Thomas, Stephen
IR  - Thomas S
FIR - Thornton, George D
IR  - Thornton GD
FIR - Treibel, Thomas A
IR  - Treibel TA
FIR - Tucker, Art
IR  - Tucker A
FIR - Veerapen, Jessry
IR  - Veerapen J
FIR - Vijayakumar, Mohit
IR  - Vijayakumar M
FIR - Welch, Sophie
IR  - Welch S
FIR - Wodehouse, Theresa
IR  - Wodehouse T
FIR - Wynne, Lucinda
IR  - Wynne L
FIR - Zahedi, Dan
IR  - Zahedi D
FIR - Chain, Benjamin
IR  - Chain B
EDAT- 2021/05/02 06:00
MHDA- 2021/05/02 06:00
PMCR- 2021/04/30
CRDT- 2021/05/01 05:57
PHST- 2021/02/21 00:00 [received]
PHST- 2021/04/26 00:00 [accepted]
PHST- 2021/05/02 06:00 [pubmed]
PHST- 2021/05/02 06:00 [medline]
PHST- 2021/05/01 05:57 [entrez]
PHST- 2021/04/30 00:00 [pmc-release]
AID - science.abh1282 [pii]
AID - abh1282 [pii]
AID - 10.1126/science.abh1282 [doi]
PST - aheadofprint
SO  - Science. 2021 Apr 30;372(6549):1418-23. doi: 10.1126/science.abh1282.