PMID- 33932887
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20210622
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 204
DP  - 2021 Aug
TI  - Construction of hyperbranched and pH-responsive polymeric nanocarriers by 
      yne-phenol click-reaction for tumor synergistic chemotherapy.
PG  - 111790
LID - S0927-7765(21)00234-4 [pii]
LID - 10.1016/j.colsurfb.2021.111790 [doi]
AB  - In past decades, to improve the chemotherapeutic efficiency and reduce the 
      systemic toxicity of small molecule anti-cancer drugs, polymer-based drug 
      delivery systems (DDSs) have attracted great attention for tumor treatment due to 
      their remarkable biocompatibility and responsive degradation in tumor 
      microenvironment (TME). Herein, we developed a kind of pH-responsive and 
      degradable hyperbranched polymeric nanocarriers via yne-phenol click-reaction of 
      resveratrol (RSV) with bifunctional n-butyl dipropiolate (BDP) for efficient 
      doxorubicin (DOX) delivery. The natural product RSV with three phenol groups has 
      excellent antioxidant activity and synergetic enhancement for some anticancer 
      drugs such as DOX. RSV tends to attack the alkynyl groups on BDP by nucleophilic 
      addition in the presence of base as catalyst to afford hyperbranched polyprodrug 
      (denoted as RB). PEGylated RB (termed as RBP) were further synthesized to improve 
      the water solubility and prolong blood circulation by the click reaction of 
      propiolate-terminated RB with amino terminated poly(ethylene glycol) (PEG-NH(2)). 
      Interestingly, the RBP have high DOX loading ratio ( approximately 58.6 %) at neutral pH, but 
      the vinyl-ether bonds in RB could break down at low pH conditions such as acidic 
      TME (extracellular pH approximately 6.8, endosomes and lysosomes pH approximately 5.0) that leading to the 
      targeting release of DOX and RSV. Therefore, the developed RBP@DOX nanoparticles 
      exhibited high kill efficiency to tumor cells and slight damage to normal cells 
      due to the effective delivery and release of DOX and RSV in tumor sites and the 
      synergistic enhancement effect of two drugs.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Zhang, Ning
AU  - Zhang N
AD  - School of Chemistry, MOE Key Laboratory for Non-equilibrium Synthesis and 
      Modulation of Condensed Matter, Xi'an Key Laboratory of Sustainable Energy 
      Material Chemistry, Xi'an Jiaotong University, Xi'an, 710049, PR China.
FAU - Wang, Daquan
AU  - Wang D
AD  - School of Chemistry, MOE Key Laboratory for Non-equilibrium Synthesis and 
      Modulation of Condensed Matter, Xi'an Key Laboratory of Sustainable Energy 
      Material Chemistry, Xi'an Jiaotong University, Xi'an, 710049, PR China. 
      Electronic address: wangdaquan2019@mail.xjtu.edu.cn.
FAU - Yang, Tingting
AU  - Yang T
AD  - School of Chemistry, MOE Key Laboratory for Non-equilibrium Synthesis and 
      Modulation of Condensed Matter, Xi'an Key Laboratory of Sustainable Energy 
      Material Chemistry, Xi'an Jiaotong University, Xi'an, 710049, PR China.
FAU - Jing, Xunan
AU  - Jing X
AD  - Talent Highland, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 
      710061, PR China.
FAU - Meng, Lingjie
AU  - Meng L
AD  - School of Chemistry, MOE Key Laboratory for Non-equilibrium Synthesis and 
      Modulation of Condensed Matter, Xi'an Key Laboratory of Sustainable Energy 
      Material Chemistry, Xi'an Jiaotong University, Xi'an, 710049, PR China; 
      Instrumental Analysis Center, Xi'an Jiaotong University, Xi'an, 710049, PR China. 
      Electronic address: menglingjie@mail.xjtu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210426
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Polymers)
RN  - 339NCG44TV (Phenol)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Cell Line, Tumor
MH  - *Doxorubicin/pharmacology
MH  - Drug Delivery Systems
MH  - Hydrogen-Ion Concentration
MH  - *Phenol
MH  - Polyethylene Glycols
MH  - Polymers
OTO - NOTNLM
OT  - Click-reaction
OT  - Doxorubicin (DOX)
OT  - Drug delivery systems (DDSs)
OT  - Hyperbranched polymer
OT  - pH-responsive
EDAT- 2021/05/02 06:00
MHDA- 2021/06/23 06:00
CRDT- 2021/05/01 20:25
PHST- 2021/01/17 00:00 [received]
PHST- 2021/04/02 00:00 [revised]
PHST- 2021/04/25 00:00 [accepted]
PHST- 2021/05/02 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2021/05/01 20:25 [entrez]
AID - S0927-7765(21)00234-4 [pii]
AID - 10.1016/j.colsurfb.2021.111790 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2021 Aug;204:111790. doi: 
      10.1016/j.colsurfb.2021.111790. Epub 2021 Apr 26.