PMID- 33933501
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20211124
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 178
DP  - 2021 Aug
TI  - Comorbidities and complications in Japanese patients with type 2 diabetes 
      mellitus: Retrospective analyses of J-DREAMS, an advanced electronic medical 
      records database.
PG  - 108845
LID - S0168-8227(21)00204-7 [pii]
LID - 10.1016/j.diabres.2021.108845 [doi]
AB  - AIMS: To investigate the prevalence of comorbid conditions/complications among 
      Japanese patients with type 2 diabetes mellitus (T2DM) in a real-world setting. 
      METHODS: We performed retrospective analyses of a large-scale database directly 
      linked to electronic medical records, J-DREAMS (Japan Diabetes compREhensive 
      database project based on an Advanced electronic Medical record System), to 
      determine the prevalence of clinically significant comorbid 
      conditions/complications among Japanese patients with T2DM aged >/= 20 years 
      with >/= 1 clinical encounter at a referral center between April 1, 2017 and March 
      31, 2019. RESULTS: Data were available for 10,151 patients (39.2% female). The 
      mean age and T2DM duration were 66.0 years and 16.1 years, respectively. Only 
      0.5% had isolated T2DM, 6.6% had one comorbid condition/complication, and the 
      remainder had multiple comorbid conditions/complications. Dyslipidemia (84.7%) 
      and hypertension (75.1%) were the most common, followed by chronic kidney disease 
      (35.4%), retinopathy (23.1%), and cardiovascular diseases (22.1%). Overall, 36.0% 
      of patients were overweight/obese (body mass index >/= 25 kg/m(2)) and 18.6% had a 
      history of neoplasms. The prevalence of comorbid conditions/complications tended 
      to increase with advancing age and duration of T2DM. CONCLUSIONS: We revealed a 
      high prevalence of comorbid conditions/complications, including chronic kidney 
      and cardiovascular diseases, in Japanese patients with T2DM.
CI  - Copyright (c) 2021 Merck Sharp & Dohme Corp., The Author(s). Published by Elsevier 
      B.V. All rights reserved.
FAU - Ohsugi, Mitsuru
AU  - Ohsugi M
AD  - Diabetes and Metabolism Information Center, Research Institute, National Center 
      for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, 
      Japan. Electronic address: moosugi@hosp.ncgm.go.jp.
FAU - Eiki, Jun-Ichi
AU  - Eiki JI
AD  - Medical Affairs, MSD K.K., 1-13-12 Kudan-kita, Chiyoda-ku, Tokyo 102-8667, Japan. 
      Electronic address: junichi.eiki@merck.com.
FAU - Iglay, Kristy
AU  - Iglay K
AD  - Center for Observational and Real-World Evidence, Merck & Co., Inc., Kenilworth, 
      NJ, USA. Electronic address: kristy.iglay@laylen.com.
FAU - Tetsuka, Jumpei
AU  - Tetsuka J
AD  - Medical Affairs, MSD K.K., 1-13-12 Kudan-kita, Chiyoda-ku, Tokyo 102-8667, Japan. 
      Electronic address: jumpei.tetsuka@merck.com.
FAU - Tokita, Shigeru
AU  - Tokita S
AD  - Medical Affairs, MSD K.K., 1-13-12 Kudan-kita, Chiyoda-ku, Tokyo 102-8667, Japan. 
      Electronic address: shigeru.tokita@merck.com.
FAU - Ueki, Kohjiro
AU  - Ueki K
AD  - Diabetes Research Center, Research Institute, National Center for Global Health 
      and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan; Department of 
      Molecular Diabetology, Graduate School of Medicine, The University of Tokyo, 
      7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: 
      uekik@ri.ncgm.go.jp.
LA  - eng
PT  - Journal Article
DEP - 20210430
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Child, Preschool
MH  - Comorbidity
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Electronic Health Records
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Prevalence
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Chronic kidney disease
OT  - Comorbid conditions
OT  - Complications
OT  - Real-world data
OT  - Type 2 diabetes mellitus
EDAT- 2021/05/03 06:00
MHDA- 2021/11/25 06:00
CRDT- 2021/05/02 20:43
PHST- 2020/12/17 00:00 [received]
PHST- 2021/03/25 00:00 [revised]
PHST- 2021/04/27 00:00 [accepted]
PHST- 2021/05/03 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
PHST- 2021/05/02 20:43 [entrez]
AID - S0168-8227(21)00204-7 [pii]
AID - 10.1016/j.diabres.2021.108845 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2021 Aug;178:108845. doi: 10.1016/j.diabres.2021.108845. 
      Epub 2021 Apr 30.