PMID- 33934110
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20230201
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 11
IP  - 1
DP  - 2021 May 1
TI  - Imaging beta-amyloid (Abeta) burden in the brains of middle-aged individuals with 
      alcohol-use disorders: a [(11)C]PIB PET study.
PG  - 257
LID - 10.1038/s41398-021-01374-y [doi]
LID - 257
AB  - No in vivo human studies have examined the prevalence of Alzheimer's disease (AD) 
      neuropathology in individuals with alcohol-use disorder (AUD), although recent 
      research suggests that a relationship between the two exists. Therefore, this 
      study used Pittsburgh Compound-B ([(11)C]PiB) PET imaging to test the hypothesis 
      that AUD is associated with greater brain amyloid (Abeta) burden in middle-aged 
      adults compared to healthy controls. Twenty healthy participants (14M and 6F) and 
      19 individuals with AUD (15M and 4F), all aged 40-65 years, underwent clinical 
      assessment, MRI, neurocognitive testing, and positron emission tomography (PET) 
      imaging. Global [(11)C]PiB standard uptake value ratios (SUVRs), cortical 
      thickness, gray matter volumes (GMVs), and neurocognitive function in subjects 
      with AUD were compared to healthy controls. These measures were selected because 
      they are considered markers of risk for future AD and other types of 
      neurocognitive dysfunction. The results of this study showed no significant 
      differences in % global Abeta positivity or subthreshold Abeta loads between AUD and 
      controls. However, relative to controls, we observed a significant 6.1% lower 
      cortical thickness in both AD-signature regions and in regions not typically 
      associated with AD, lower GMV in the hippocampus, and lower performance on tests 
      of attention as well as immediate and delayed memory in individuals with AUD. 
      This suggest that Abeta accumulation is not greater in middle-aged individuals with 
      AUD. However, other markers of neurodegeneration, such as impaired memory, 
      cortical thinning, and reduced hippocampal GMV, are present. Further studies are 
      needed to elucidate the patterns and temporal staging of AUD-related 
      pathophysiology and cognitive impairment. Imaging beta-amyloid in middle age 
      alcoholics as a mechanism that increases their risk for Alzheimer's disease; 
      Registration Number: NCT03746366 .
FAU - Flanigan, Margaret R
AU  - Flanigan MR
AUID- ORCID: 0000-0003-3706-4334
AD  - Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA. 
      flaniganm@upmc.edu.
FAU - Royse, Sarah K
AU  - Royse SK
AUID- ORCID: 0000-0003-4846-0180
AD  - Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Cenkner, David P
AU  - Cenkner DP
AD  - Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Kozinski, Katelyn M
AU  - Kozinski KM
AD  - Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Stoughton, Clara J
AU  - Stoughton CJ
AD  - Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Himes, Michael L
AU  - Himes ML
AD  - Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Minhas, Davneet S
AU  - Minhas DS
AD  - Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Lopresti, Brian
AU  - Lopresti B
AD  - Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Butters, Meryl A
AU  - Butters MA
AUID- ORCID: 0000-0002-2563-817X
AD  - Department Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Narendran, Rajesh
AU  - Narendran R
AUID- ORCID: 0000-0002-4292-2850
AD  - Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
AD  - Department Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT03746366
GR  - R01 AA025247/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210501
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Aniline Compounds)
SB  - IM
MH  - *Alzheimer Disease/diagnostic imaging
MH  - *Amyloid beta-Peptides/metabolism
MH  - Aniline Compounds
MH  - Brain/diagnostic imaging/metabolism
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Positron-Emission Tomography
PMC - PMC8088438
COIS- The authors declare no competing interest.
EDAT- 2021/05/03 06:00
MHDA- 2021/06/29 06:00
PMCR- 2021/05/01
CRDT- 2021/05/02 21:04
PHST- 2020/11/13 00:00 [received]
PHST- 2021/04/07 00:00 [accepted]
PHST- 2021/03/13 00:00 [revised]
PHST- 2021/05/02 21:04 [entrez]
PHST- 2021/05/03 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/05/01 00:00 [pmc-release]
AID - 10.1038/s41398-021-01374-y [pii]
AID - 1374 [pii]
AID - 10.1038/s41398-021-01374-y [doi]
PST - epublish
SO  - Transl Psychiatry. 2021 May 1;11(1):257. doi: 10.1038/s41398-021-01374-y.