PMID- 33934473
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210708
IS  - 1473-2165 (Electronic)
IS  - 1473-2130 (Print)
IS  - 1473-2130 (Linking)
VI  - 20 Suppl 1
IP  - Suppl 1
DP  - 2021 Apr
TI  - Topical oil formulation of plant extracts and vitamins as effective treatment for 
      stretch marks and xerosis-An observational longitudinal study.
PG  - 9-13
LID - 10.1111/jocd.14094 [doi]
AB  - BACKGROUND: Stretch marks are linear scars that result from elastic fiber 
      destruction. They usually occur as the consequence of rapid change in the body 
      mass (weight gain and loss, pregnancy, weightlifting), long-term steroid use, or 
      endocrinopathies. Treatment is challenging and mainly based on topical and 
      procedural therapies, although the standard of care is still under debate. 
      PURPOSE: To evaluate the efficacy and tolerance of a topical oil formulation of 
      plant extracts and vitamins on the aesthetic improvement of stretch marks and 
      xerosis. MATERIALS AND METHODS: Fifty male and female patients, aged between 14 
      and 45 years, with stretch marks referring at the University Hospital Federico 
      II, Naples, were enrolled between March and November 2019. Topical application of 
      plant extracts and vitamin-rich oil was performed twice daily on affected skin 
      for 4 months. Patients were monitored at baseline (T0), and at two-month (T1) and 
      4-month (T2) follow-ups, through clinical and dermoscopic assessment, confocal 
      microscopy, cutaneous ultrasound, MoistureMeterEpiD, and X-Rite 
      spectrocolorimeter. Primary endpoints were as follows: 70% clinical improvement 
      of stretch marks and 3-point decrease in clinical score from baseline to T2. 
      Secondary endpoints were as follows: change in the T0 parallel pattern of 
      collagen fibers at confocal microscopy, cutaneous thickness increase at 
      ultrasounds, cutaneous hydration increase at MoistureMeterEpiD, erythema 
      reduction at X-Rite spectrocolorimeter, and safety and adverse events (AEs). 
      RESULTS: At 4-month follow-up, stretch marks improved objectively and 
      subjectively in all patients (p < 0.001). In detail, there was a 29% and 71% 
      improvement in clinical appearance of stretch marks at T1 and T2, respectively, 
      as documented dermoscopically and by the 3-point reduction in the assessor's mean 
      clinical score at each follow-up visits [from 8.1+/-0.7 at baseline to 5.7+/-1.0 at 
      T1 and 2.3 +/-0.5 at T2 (p < 0.001)]. Erythema decreased by 15% and 30% and in 
      parallel hydration increased by 25% and 71%, at T1 and T2, respectively 
      (p < 0.001). At T2 confocal microscopy of stretch marks, dermal collagenous 
      fibers assumed casual disposition with reticular pattern and refractivity, as 
      signs of collagen remodeling and neocollagenesis, and also the T2 cutaneous 
      ultrasound revealed increased epidermal thickness and decreased dermal 
      hypoechogenicity as for a higher skin hydration. CONCLUSION: Our study showed 
      that a topical oil formulation rich in plant extracts and vitamins appears to be 
      effective and safe in treating stretch marks and xerosis.
CI  - (c) 2021 The Authors. Journal of Cosmetic Dermatology published by Wiley 
      Periodicals LLC.
FAU - Cantelli, Mariateresa
AU  - Cantelli M
AD  - Section of Dermatology, Department of Clinical Medicine and Surgery, University 
      of Naples Federico II, Napoli, Italy.
FAU - Camela, Elisa
AU  - Camela E
AD  - Section of Dermatology, Department of Clinical Medicine and Surgery, University 
      of Naples Federico II, Napoli, Italy.
FAU - Marasca, Claudio
AU  - Marasca C
AD  - Section of Dermatology, Department of Clinical Medicine and Surgery, University 
      of Naples Federico II, Napoli, Italy.
FAU - Fontanella, Giuseppina
AU  - Fontanella G
AD  - Section of Dermatology, Department of Clinical Medicine and Surgery, University 
      of Naples Federico II, Napoli, Italy.
FAU - Blasio, Chiara
AU  - Blasio C
AD  - Section of Dermatology, Department of Clinical Medicine and Surgery, University 
      of Naples Federico II, Napoli, Italy.
FAU - Fabbrocini, Gabriella
AU  - Fabbrocini G
AD  - Section of Dermatology, Department of Clinical Medicine and Surgery, University 
      of Naples Federico II, Napoli, Italy.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Cosmet Dermatol
JT  - Journal of cosmetic dermatology
JID - 101130964
RN  - 0 (Plant Extracts)
RN  - 0 (Vitamins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Plant Extracts/therapeutic use
MH  - Pregnancy
MH  - Skin
MH  - *Striae Distensae/drug therapy
MH  - Vitamins/therapeutic use
MH  - Young Adult
PMC - PMC8251840
OTO - NOTNLM
OT  - MoistureMeterEpiD
OT  - Stretch marks
OT  - confocal microscopy
OT  - cutaneous ultrasound
OT  - dermoscopy
OT  - oil
OT  - spectrocolorimeter
OT  - topical treatment
OT  - xerosis
COIS- None to declare.
EDAT- 2021/05/03 06:00
MHDA- 2021/05/15 06:00
PMCR- 2021/07/02
CRDT- 2021/05/02 21:20
PHST- 2021/03/16 00:00 [accepted]
PHST- 2021/05/02 21:20 [entrez]
PHST- 2021/05/03 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/07/02 00:00 [pmc-release]
AID - JOCD14094 [pii]
AID - 10.1111/jocd.14094 [doi]
PST - ppublish
SO  - J Cosmet Dermatol. 2021 Apr;20 Suppl 1(Suppl 1):9-13. doi: 10.1111/jocd.14094.