PMID- 33934787
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 230
DP  - 2021 Aug 1
TI  - In-situ growth of a spherical vinyl-functionalized covalent organic framework as 
      stationary phase for capillary electrochromatography-mass spectrometry analysis.
PG  - 122330
LID - S0039-9140(21)00251-4 [pii]
LID - 10.1016/j.talanta.2021.122330 [doi]
AB  - Column technology is an important part in capillary electrochromatographic 
      science. Developing novel stationary phase with high separation efficiency and 
      high loading capacity is an essential work. In this work, a novel spherical 
      vinyl-functionalized covalent-organic framework (COF-V) was synthesized at room 
      temperature and firstly employed as stationary phase for CEC-MS analysis. The 
      COF-V based CEC column was characterized by scanning electron microscopy, X-ray 
      diffraction and Fourier transform infrared spectroscopy. The results proved the 
      successful modification of COF-V. The COF-V based column possesses the advantages 
      like strong electroosmotic flow, high separation efficiency and high loading 
      capacity. The CEC column showed powerful separation selectivity to several kinds 
      of compounds, and the highest column efficiency (theoretical plates, N) was over 
      1.4 x 10(5) plates.m(-1) for methylbenzene. Besides, the COF-V modified column 
      exhibited excellent repeatability and stability. The relative standard deviations 
      (RSDs) of retention times for intra-day (n = 5), inter-day (n = 3) runs and 
      column-to-column (n = 3) were all less than 2.1%. Hence, the COF-V modified 
      column was successfully applied in CEC-MS for determination of antiepileptic 
      drug, triazine herbicides and active ingredients in traditional Chinese medicine.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Sun, Wenqi
AU  - Sun W
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of 
      Education, Hubei Province Engineering and Technology Research Center for 
      Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, 
      Wuhan, 430071, China; State Key Laboratory of Transducer Technology, Chinese 
      Academy of Sciences, Beijing, 100080, China.
FAU - Liu, Yikun
AU  - Liu Y
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of 
      Education, Hubei Province Engineering and Technology Research Center for 
      Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, 
      Wuhan, 430071, China; State Key Laboratory of Transducer Technology, Chinese 
      Academy of Sciences, Beijing, 100080, China.
FAU - Zhou, Wei
AU  - Zhou W
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of 
      Education, Hubei Province Engineering and Technology Research Center for 
      Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, 
      Wuhan, 430071, China.
FAU - Li, Zhentao
AU  - Li Z
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of 
      Education, Hubei Province Engineering and Technology Research Center for 
      Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, 
      Wuhan, 430071, China.
FAU - Chen, Zilin
AU  - Chen Z
AD  - Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of 
      Education, Hubei Province Engineering and Technology Research Center for 
      Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, 
      Wuhan, 430071, China; State Key Laboratory of Transducer Technology, Chinese 
      Academy of Sciences, Beijing, 100080, China. Electronic address: 
      chenzl@whu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210323
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Metal-Organic Frameworks)
SB  - IM
MH  - *Capillary Electrochromatography
MH  - Electroosmosis
MH  - Mass Spectrometry
MH  - *Metal-Organic Frameworks
MH  - X-Ray Diffraction
OTO - NOTNLM
OT  - Capillary electrochromatography
OT  - Covalent organic frameworks
OT  - Mass spectrometry
OT  - Open-tubular column
EDAT- 2021/05/04 06:00
MHDA- 2021/05/15 06:00
CRDT- 2021/05/03 05:42
PHST- 2021/01/06 00:00 [received]
PHST- 2021/03/16 00:00 [revised]
PHST- 2021/03/18 00:00 [accepted]
PHST- 2021/05/03 05:42 [entrez]
PHST- 2021/05/04 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
AID - S0039-9140(21)00251-4 [pii]
AID - 10.1016/j.talanta.2021.122330 [doi]
PST - ppublish
SO  - Talanta. 2021 Aug 1;230:122330. doi: 10.1016/j.talanta.2021.122330. Epub 2021 Mar 
      23.