PMID- 33936237 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210504 IS - 1735-5303 (Print) IS - 2345-3656 (Electronic) IS - 1735-5303 (Linking) VI - 16 IP - 2 DP - 2021 Spring TI - Interdigitating Dendritic Cell Tumor of Submandibular Lymph Node: Case Report and Literature Review. PG - 237-242 LID - 10.30699/IJP.2020.120698.2411 [doi] AB - Dendritic cells (DCs) are key arms of immune system, which act in antigen presenting processes, and are considered as a bridge between innate and adaptive immune responses. DCs are found in both lymphoid and non-lymphoid organs. They are called interdigitating dendritic cells (IDCs) in secondary lymphoid organs. IDCs lack lineage surface markers and are positive for S-100 and vimentin. IDC sarcoma (IDCS) is a very rare neoplasm, which mainly affects lymph nodes, though there are reports of extra-nodal involvement. IDCS is thought to have poor prognosis. Although there is no consensus on the treatment modalities, such options as radical surgery, chemotherapy, and radiotherapy are performed depending on severity and site of the lesion. In this study, we present a case of IDCS in a 53-year-old male with a history of several skin lesions and prior diagnoses of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and metatypical carcinoma (MTC). FAU - Felezi, Soroush AU - Felezi S AD - Department of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran. FAU - Nosrati, Anahita AU - Nosrati A AD - Department of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran. FAU - Eslami Jouybari, Mohammad AU - Eslami Jouybari M AD - Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran. FAU - Jafarshad, Javane AU - Jafarshad J AD - Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. LA - eng PT - Case Reports DEP - 20201221 PL - Iran TA - Iran J Pathol JT - Iranian journal of pathology JID - 101515128 PMC - PMC8085297 OTO - NOTNLM OT - Dendritic cell OT - Interdigitating dendritic cell tumor OT - Lymph node OT - Sarcoma OT - Submandibular EDAT- 2021/05/04 06:00 MHDA- 2021/05/04 06:01 PMCR- 2021/03/01 CRDT- 2021/05/03 06:13 PHST- 2020/06/14 00:00 [received] PHST- 2020/09/16 00:00 [accepted] PHST- 2021/05/03 06:13 [entrez] PHST- 2021/05/04 06:00 [pubmed] PHST- 2021/05/04 06:01 [medline] PHST- 2021/03/01 00:00 [pmc-release] AID - 10.30699/IJP.2020.120698.2411 [doi] PST - ppublish SO - Iran J Pathol. 2021 Spring;16(2):237-242. doi: 10.30699/IJP.2020.120698.2411. Epub 2020 Dec 21.