PMID- 33936819
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210504
IS  - 2090-6501 (Print)
IS  - 2090-651X (Electronic)
IS  - 2090-651X (Linking)
VI  - 2021
DP  - 2021
TI  - "Primary Hyperparathyroidism (PHPT) in Children: Two Case Reports and Review of 
      the Literature".
PG  - 5539349
LID - 10.1155/2021/5539349 [doi]
LID - 5539349
AB  - Primary hyperparathyroidism (PHPT) is a rare disorder in children and 
      adolescents. Typical biochemical features are hypercalcemia and hypophosphatemia, 
      but the clinical features can be heterogeneous, and in some cases, symptoms are 
      vague and nonspecific, leading to misdiagnosis or late diagnosis. Herein, we 
      report two cases of PHPT in pediatric age with different presenting symptoms, 
      pain in the foot, and progressive alteration of the gait in the first case and 
      recurrent abdominal pain with emotional lability in the second. Biochemical and 
      radiological assessment confirmed PHPT. Both cases were treated surgically as 
      definitive treatment, but in the second case, previous medical treatment with 
      cinacalcet, a calcimimetic agent, was required to reduce serum PTH and calcium 
      levels. After surgery, despite conventional treatment with calcium and 
      calcitriol, case 1 developed a hungry bone syndrome. The analysis of the MEN-1 
      (Multiple Endocrine Neoplasia) gene was negative in both cases. A diagnosis of 
      PHPT should be considered when children or adolescents present bone pain with 
      radiological imaging of osteolytic lesion and biochemical feature of 
      hypercalcemia associated with hypophosphatemia. In PHPT, the gold standard 
      treatment is represented by surgery followed by strict postoperative endocrine 
      monitoring to maintain adequate homeostasis of calcium and bone metabolism.
CI  - Copyright (c) 2021 Gerdi Tuli et al.
FAU - Tuli, Gerdi
AU  - Tuli G
AUID- ORCID: 0000-0001-5862-8958
AD  - Department of Pediatric Endocrinology, Regina Margherita Children's Hospital of 
      Turin, Turin, Italy.
AD  - Department of Sciences of Public Health and Pediatrics, University of Turin, 
      Turin, Italy.
FAU - Munarin, Jessica
AU  - Munarin J
AUID- ORCID: 0000-0002-5075-8448
AD  - Department of Pediatric Endocrinology, Regina Margherita Children's Hospital of 
      Turin, Turin, Italy.
AD  - Department of Sciences of Public Health and Pediatrics, University of Turin, 
      Turin, Italy.
FAU - Tessaris, Daniele
AU  - Tessaris D
AUID- ORCID: 0000-0002-6484-4371
AD  - Department of Pediatric Endocrinology, Regina Margherita Children's Hospital of 
      Turin, Turin, Italy.
AD  - Department of Sciences of Public Health and Pediatrics, University of Turin, 
      Turin, Italy.
FAU - Buganza, Raffaele
AU  - Buganza R
AUID- ORCID: 0000-0003-1850-2300
AD  - Department of Pediatric Endocrinology, Regina Margherita Children's Hospital of 
      Turin, Turin, Italy.
AD  - Department of Sciences of Public Health and Pediatrics, University of Turin, 
      Turin, Italy.
FAU - Matarazzo, Patrizia
AU  - Matarazzo P
AUID- ORCID: 0000-0001-7601-786X
AD  - Department of Pediatric Endocrinology, Regina Margherita Children's Hospital of 
      Turin, Turin, Italy.
AD  - Department of Sciences of Public Health and Pediatrics, University of Turin, 
      Turin, Italy.
FAU - De Sanctis, Luisa
AU  - De Sanctis L
AUID- ORCID: 0000-0003-2113-6196
AD  - Department of Pediatric Endocrinology, Regina Margherita Children's Hospital of 
      Turin, Turin, Italy.
AD  - Department of Sciences of Public Health and Pediatrics, University of Turin, 
      Turin, Italy.
LA  - eng
PT  - Case Reports
DEP - 20210413
PL  - United States
TA  - Case Rep Endocrinol
JT  - Case reports in endocrinology
JID - 101576457
PMC - PMC8060104
COIS- All authors declare no conflicts of interest.
EDAT- 2021/05/04 06:00
MHDA- 2021/05/04 06:01
PMCR- 2021/04/13
CRDT- 2021/05/03 06:18
PHST- 2021/02/02 00:00 [received]
PHST- 2021/03/29 00:00 [revised]
PHST- 2021/04/08 00:00 [accepted]
PHST- 2021/05/03 06:18 [entrez]
PHST- 2021/05/04 06:00 [pubmed]
PHST- 2021/05/04 06:01 [medline]
PHST- 2021/04/13 00:00 [pmc-release]
AID - 10.1155/2021/5539349 [doi]
PST - epublish
SO  - Case Rep Endocrinol. 2021 Apr 13;2021:5539349. doi: 10.1155/2021/5539349. 
      eCollection 2021.