PMID- 33937756
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 2651-2823 (Electronic)
IS  - 2630-6158 (Print)
IS  - 2651-2823 (Linking)
VI  - 55
IP  - 1
DP  - 2021 Jan 4
TI  - The antibacterial effects of vitamin D3 against mutans streptococci: an in vitro 
      study.
PG  - 8-15
LID - 10.26650/eor.20210119 [doi]
AB  - PURPOSE: This study aims to evaluate the antimicrobial effects of the 
      cholecalciferol vitamin D3 against Streptococcus sobrinus (Strep. sobrinus) and 
      Streptococcus mutans (Strep. mutans) bacteria in vitro that is considered the 
      main causative bacteria in dental caries development. MATERIALS AND METHODS: The 
      antimicrobial effects of vitamin D3 were evaluated against Strep. sobrinus and 
      Strep mutans using the agar disc diffusion method. The minimum inhibitory 
      concentration (MIC) and minimum bactericidal concentration (MBC) of vitamin D3 
      were determined using a microdilution method following the guidelines by the 
      Clinical Laboratory Standards Institute (CLSI). Scanning electron microscope 
      (SEM) was used to evaluate the morphological changes of bacterial cells following 
      exposure to vitamin D3. RESULTS: Strep. sobrinus was more sensitive to vitamin D3 
      compared to Strep. mutans bacteria. The MIC values of vitamin D3 against Strep. 
      sobrinus and Strep. mutans were 60 mug/ mL and 250 mug/mL respectively whereas the 
      MBC values were 120 mug/mL and 500 mug/mL, respectively. Moreover, significant 
      changes in the bacterial morphology were observed in treated bacterial cells with 
      vitamin D3 as compared to the untreated control bacteria using SEM. CONCLUSION: 
      These findings suggested that vitamin D3 has excellent antimicrobial effects 
      against Strep. sobrinus and Strep. mutans and may be considered as a promising 
      compound in the prevention of dental caries in the future. Further research is 
      recommended to elucidate the mechanism of vitamin D3 on these bacteria.
CI  - Copyright (c) 2021 European Oral Research.
FAU - Almoudi, Manal Mohamed Mansour
AU  - Almoudi MMM
AD  - Centre of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, Universiti 
      Teknologi MARA, Selangor, Malaysia.
FAU - Hussein, Alaa Sabah
AU  - Hussein AS
AD  - Centre of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, Universiti 
      Teknologi MARA, Selangor, Malaysia.
FAU - Abu Hassan, Mohamed Ibrahim
AU  - Abu Hassan MI
AD  - Centre of Restorative Dentistry Studies, Faculty of Dentistry, Universiti 
      Teknologi MARA, Selangor, Malaysia.
FAU - Al-Talib, Hassanain
AU  - Al-Talib H
AD  - Medical Microbiology and Parasitology Department,Faculty of Medicine, Universiti 
      Teknologi MARA,Selangor,Malaysia.
FAU - Khan, Hasnah Begum Said Gulam
AU  - Khan HBSG
AD  - Centre of PreClinical Science Studies, Faculty of Dentistry,Universiti Teknologi 
      MARA, Selangor,Malaysia.
FAU - Nazli, Siti Arisya Binti
AU  - Nazli SAB
AD  - Faculty of Dentistry, Universiti Teknologi MARA,Selangor,Malaysia.
FAU - Effandy, Nur Aina Efira Binti
AU  - Effandy NAEB
AD  - Faculty of Dentistry, Universiti Teknologi MARA,Selangor,Malaysia.
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Eur Oral Res
JT  - European oral research
JID - 101738487
PMC - PMC8055259
OTO - NOTNLM
OT  - Cholecalciferol
OT  - Streptococcus mutans
OT  - Streptococcus sobrinus
OT  - Vitamin D3
OT  - antibacterial effect
EDAT- 2021/05/04 06:00
MHDA- 2021/05/04 06:01
PMCR- 2021/01/04
CRDT- 2021/05/03 06:27
PHST- 2021/05/03 06:27 [entrez]
PHST- 2021/05/04 06:00 [pubmed]
PHST- 2021/05/04 06:01 [medline]
PHST- 2021/01/04 00:00 [pmc-release]
AID - eor-55-1-2019-0119 [pii]
AID - 10.26650/eor.20210119 [doi]
PST - ppublish
SO  - Eur Oral Res. 2021 Jan 4;55(1):8-15. doi: 10.26650/eor.20210119.