PMID- 33938203
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20220422
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 49
IP  - 3
DP  - 2021
TI  - Treatment with proton pump inhibitors as a cofactor in adverse reactions of 
      patients undergoing oral food immunotherapy.
PG  - 169-172
LID - 10.15586/aei.v49i3.58 [doi]
AB  - BACKGROUND AND OBJECTIVES: Based on previous studies revealing acid-suppression 
      medication as a risk factor for food allergy tolerance induction, we aimed to 
      establish the importance of those findings in patients undergoing oral 
      immunotherapy (OIT). MATERIALS AND METHODS, RESULTS: We describe a case series of 
      four patients who underwent milk OIT with a concomitant use of proton pump 
      inhibitor (PPI) medication and who developed anaphylaxis after a known, 
      previously tolerated dose of milk. CONCLUSIONS: PPIs may act as a cofactor in 
      patients undergoing OIT, triggering adverse reactions, irrespective of the PPI 
      used or the dosage. It would be necessary to separate the administration of drug 
      from food intake.Since OIT is a new form of treatment, long-term adverse events 
      arising from PPI treatment and other possible triggers are still uncertain. 
      Consequently, monitoring of patient must be prolonged over time. Additional 
      investigations on the influence of different drugs in OIT maintenance phase are 
      required.
FAU - Vega, Marta Garcia
AU  - Vega MG
AD  - Department of Pediatric Gastroenterology, Severo Ochoa University Hospital, 
      Leganes, Madrid, Spain; mgarciavega6@gmail.com.
FAU - Alonso, Sara Bellon
AU  - Alonso SB
AD  - Department of Pediatric Pneumology, Gregorio Maranon University Hospital, Madrid, 
      Spain.
FAU - Espana, Amelia Perez
AU  - Espana AP
AD  - Department of Pediatric Allergology, Severo Ochoa University Hospital, Leganes, 
      Madrid, Spain.
FAU - Teruel, Sergio Jose Quevedo
AU  - Teruel SJQ
AD  - Department of Pediatric Allergology, Severo Ochoa University Hospital, Leganes, 
      Madrid, Spain.
FAU - Fernandez, Sonia Fernandez
AU  - Fernandez SF
AD  - Department of Pediatric Gastroenterology, Severo Ochoa University Hospital, 
      Leganes, Madrid, Spain.
FAU - Bermejo, Teresa Bracamonte
AU  - Bermejo TB
AD  - Department of Pediatric Allergology, Severo Ochoa University Hospital, Leganes, 
      Madrid, Spain.
FAU - Zudaire, Luis Echeverria
AU  - Zudaire LE
AD  - Department of Pediatric Allergology, Severo Ochoa University Hospital, Leganes, 
      Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210501
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anaphylaxis/*etiology
MH  - Animals
MH  - Child
MH  - Desensitization, Immunologic/adverse effects/*methods
MH  - Eosinophilic Esophagitis/*therapy
MH  - Female
MH  - Food Hypersensitivity/*therapy
MH  - Gastritis/*therapy
MH  - Humans
MH  - Male
MH  - Milk
MH  - Proton Pump Inhibitors/*adverse effects
OTO - NOTNLM
OT  - adverse reaction
OT  - anaphylaxis
OT  - cofactor
OT  - food allergy
OT  - oral immunotherapy
OT  - proton pump inhibitors
EDAT- 2021/05/04 06:00
MHDA- 2021/11/16 06:00
CRDT- 2021/05/03 06:48
PHST- 2020/11/06 00:00 [received]
PHST- 2021/03/17 00:00 [accepted]
PHST- 2021/05/03 06:48 [entrez]
PHST- 2021/05/04 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
AID - 10.15586/aei.v49i3.58 [doi]
PST - epublish
SO  - Allergol Immunopathol (Madr). 2021 May 1;49(3):169-172. doi: 
      10.15586/aei.v49i3.58. eCollection 2021.