PMID- 33938349
OWN - NLM
STAT- MEDLINE
DCOM- 20220210
LR  - 20220531
IS  - 1364-6893 (Electronic)
IS  - 0144-3615 (Linking)
VI  - 42
IP  - 2
DP  - 2022 Feb
TI  - Elevated circulating Selenoprotein P levels in patients with polycystic ovary 
      syndrome.
PG  - 289-293
LID - 10.1080/01443615.2021.1887112 [doi]
AB  - Selenoprotein P (SeP), an hepatokine that is primarily produced by liver, has 
      been reported to affect glucose metabolism. In this study, we aimed to measure 
      and compare serum SeP values in patients with polycystic ovary syndrome (PCOS) 
      and a healthy control group, and to investigate whether there was a relationship 
      between SeP values and insulin resistance in patients with PCOS. This prospective 
      case-control study included 40 patients with PCOS and 39 healthy women (non-PCOS) 
      matched for age and body mass index. SeP levels were significantly higher in the 
      PCOS group compared with the healthy controls (7.48 +/- 3.80 vs. 5.17 +/- 3.20 mg/ml, 
      p = .005). Serum insulin, hs-CRP, HOMA-IR, FBG, total-testosterone, and 
      free-testosterone levels were higher in women with PCOS than in controls. In an 
      unadjusted model and after adjusting for potential confounders, SeP had increased 
      odds for PCOS (p = .007). ROC curve analysis showed that the area under the ROC 
      curves were 0.691 (95% CI: 0.576-0.806, p < .003) for SeP levels. The optimal 
      cut-off value of SeP for detecting PCOS was >/=5.87 mgl/ml. We showed, for the 
      first time, that serum SeP levels were increased significantly in PCOS, Our 
      results suggest that there is a potential link between PCOS and SeP levelsIMPACT 
      STATEMENTWhat is already known on this subject? Selenoprotein deficiency causes 
      various dysfunctions associated with oxidative stress, but recent studies found 
      that increased SeP levels were associated with insulin resistance. Circulating 
      SeP levels have been found to be increased in patients with type 2 diabetes 
      mellitus (T2DM).What the results of this study add? Our study is the first in the 
      literature to examine the relationship between SeP levels and the presence of 
      PCOS. Serum SeP levels were increased significantly in PCOS.What the implications 
      are of these findings for clinical practice and/or further research? SeP seemed 
      to have a role in PCOS. SeP can be used to predict metabolic disorders associated 
      with PCOS and to determine treatment methods.
FAU - Temur, Muzaffer
AU  - Temur M
AUID- ORCID: 0000-0001-9388-3882
AD  - Department of Obstetrics and Gynecology, Bursa Private Doruk Hospital, Bursa, 
      Turkey.
FAU - Tasgoz, Fatma Nurgul
AU  - Tasgoz FN
AD  - Department of Obstetrics and Gynecology, Bursa Yuksek Ihtisas Education and 
      Research Hospital, Bursa, Turkey.
FAU - Kender Erturk, Nergis
AU  - Kender Erturk N
AD  - Department of Obstetrics and Gynecology, Bursa Yuksek Ihtisas Education and 
      Research Hospital, Bursa, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210502
PL  - England
TA  - J Obstet Gynaecol
JT  - Journal of obstetrics and gynaecology : the journal of the Institute of 
      Obstetrics and Gynaecology
JID - 8309140
RN  - 0 (SELENOP protein, human)
RN  - 0 (Selenoprotein P)
SB  - IM
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Humans
MH  - *Insulin Resistance
MH  - *Polycystic Ovary Syndrome/complications
MH  - *Selenoprotein P/blood
OTO - NOTNLM
OT  - PCOS
OT  - Selenoprotein P
OT  - insulin
EDAT- 2021/05/04 06:00
MHDA- 2022/02/11 06:00
CRDT- 2021/05/03 09:10
PHST- 2021/05/04 06:00 [pubmed]
PHST- 2022/02/11 06:00 [medline]
PHST- 2021/05/03 09:10 [entrez]
AID - 10.1080/01443615.2021.1887112 [doi]
PST - ppublish
SO  - J Obstet Gynaecol. 2022 Feb;42(2):289-293. doi: 10.1080/01443615.2021.1887112. 
      Epub 2021 May 2.