PMID- 33939091
OWN - NLM
STAT- MEDLINE
DCOM- 20210920
LR  - 20230211
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 28
IP  - 36
DP  - 2021 Sep
TI  - Morin protects against acrylamide-induced neurotoxicity in rats: an investigation 
      into different signal pathways.
PG  - 49808-49819
LID - 10.1007/s11356-021-14049-4 [doi]
AB  - The presented study investigates the effects of morin against toxicity induced by 
      acrylamide (ACR) in the brains of Sprague Dawley rats. In this study, 
      neurotoxicity was induced by orally administering 38.27 mg/kg/b.w ACR to rats 
      through gastric gavage for 10 days. Morin was administered at the same time and 
      at different doses (50 and 100 mg/kg/b.w) with ACR. Biochemical and Western blot 
      analyses showed that ACR increased malondialdehyde (MDA), p38alpha mitogen-activated 
      protein kinase (p38alpha MAPK), nuclear factor kappa-B (NF-kappaB), tumor necrosis factor 
      alpha (TNF-alpha), interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), cyclooxygenase-2 
      (COX-2), p53, caspase-3, bcl-2 associated X protein (Bax), Beclin-1, light chain 
      3A (LC3A), and light chain 3B (LC3B) levels and decreased those of superoxide 
      dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), 
      b-cell lymphoma-2 (Bcl-2), mammalian target of rapamycin (mTOR), phosphoinositide 
      3-kinase (PI3K), and protein kinase B (Akt) in brain tissue and therefore induced 
      neurotoxicity by causing oxidative stress, inflammation, apoptosis, and 
      autophagy. On the other hand, it was determined that morin positively affected 
      the levels of these markers by displaying antioxidant, anti-inflammatory, 
      anti-apoptotic, and anti-autophagic properties and had a protective effect on 
      ACR-induced neurotoxicity. As a result, morin is an effective substance against 
      brain damage caused by ACR, yet further studies are needed to use it effectively.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Gur, Cihan
AU  - Gur C
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, 
      25240, Erzurum, Turkey. cihan.gur@atauni.edu.tr.
FAU - Kandemir, Fatih Mehmet
AU  - Kandemir FM
AUID- ORCID: 0000-0002-8490-2479
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, 
      25240, Erzurum, Turkey. fmehmet.kandemir@atauni.edu.tr.
FAU - Darendelioglu, Ekrem
AU  - Darendelioglu E
AD  - Department of Molecular Biology and Genetics, Faculty of Science and Literature, 
      Bingol University, Bingol, Turkey.
FAU - Caglayan, Cuneyt
AU  - Caglayan C
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Bingol University, 
      Bingol, Turkey.
FAU - Kucukler, Sefa
AU  - Kucukler S
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, 
      25240, Erzurum, Turkey.
FAU - Kandemir, Ozge
AU  - Kandemir O
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, 
      25240, Erzurum, Turkey.
FAU - Ileriturk, Mustafa
AU  - Ileriturk M
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, 
      25240, Erzurum, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210503
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Antioxidants)
RN  - 0 (Flavonoids)
RN  - 20R035KLCI (Acrylamide)
RN  - 8NFQ3F76WR (morin)
SB  - IM
MH  - *Acrylamide/toxicity
MH  - Animals
MH  - Antioxidants
MH  - Apoptosis
MH  - Flavonoids
MH  - Inflammation
MH  - Oxidative Stress
MH  - *Phosphatidylinositol 3-Kinases
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction
OTO - NOTNLM
OT  - Acrylamide
OT  - Autophagy
OT  - Inflammation
OT  - Morin
OT  - Neurotoxicity
OT  - Oxidative stress
EDAT- 2021/05/04 06:00
MHDA- 2021/09/21 06:00
CRDT- 2021/05/03 12:43
PHST- 2020/11/26 00:00 [received]
PHST- 2021/04/19 00:00 [accepted]
PHST- 2021/05/04 06:00 [pubmed]
PHST- 2021/09/21 06:00 [medline]
PHST- 2021/05/03 12:43 [entrez]
AID - 10.1007/s11356-021-14049-4 [pii]
AID - 10.1007/s11356-021-14049-4 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2021 Sep;28(36):49808-49819. doi: 
      10.1007/s11356-021-14049-4. Epub 2021 May 3.