PMID- 33939163
OWN - NLM
STAT- Publisher
LR  - 20210503
IS  - 1532-6551 (Electronic)
IS  - 1071-3581 (Linking)
DP  - 2021 Apr 30
TI  - Subacute myocardial infarction detected by technetium-99m-labeled somatostatin
      analog scintigraphy.
LID - 10.1007/s12350-021-02644-4 [doi]
AB  - Recently, the applicability of somatostatin receptor-targeted (SSTR-t)
      radiotracers for post-ischemic myocardial inflammation imaging has been shown
      using PET. Currently, there are no studies which demonstrate ability of SPECT and
      technetium-99m SSTR-t radiotracers to detect inflammation, which appears in
      response to acute myocardial infarction (AMI). A case of 51-year-old male with
      acute anterior myocardial infarction (AMI) with ST elevation has been presented. 
      This patient on 7th day after AMI onset underwent SPECT/CT (by cardiac
      cadmium-zinc-telluride gamma-camera) with (99m)Tc-Tectrotide, cardiac MRI with
      gadolinium and, on 9th day after AMI, myocardial perfusion scintigraphy (MPS) at 
      rest. Clear myocardial uptake of (99m)Tc-Tectrotide, predominantly in apical and 
      intermediate anterior wall of left ventricle was detected. The uptake matched
      with areas of hypoperfusion (by SPECT) and myocardial injury (by MRI). This case 
      demonstrated the applicability of technetium-99m-labeled SSTR-t radiotracers for 
      post-infarction inflammation imaging. Currently assumed, that SSTR-t radiotracers
      reflect an increased number of activated macrophages infiltrating infarcted
      myocardium, which is not possible using any other imaging technique. Thus,
      potentially, SSTR scintigraphy may be useful for diagnosis and monitoring of
      myocardial post-infarction inflammation as well as for anti-inflammatory
      image-guide therapy assessment.
FAU - Sazonova, S I
AU  - Sazonova SI
AD  - Cardiology Research Institute, Tomsk National Research Medical Centre, Russian
      Academy of Sciences, Tomsk, Russian Federation. sazonova_si@mail.ru.
FAU - Syrkina, A G
AU  - Syrkina AG
AD  - Cardiology Research Institute, Tomsk National Research Medical Centre, Russian
      Academy of Sciences, Tomsk, Russian Federation.
FAU - Mochula, O V
AU  - Mochula OV
AD  - Cardiology Research Institute, Tomsk National Research Medical Centre, Russian
      Academy of Sciences, Tomsk, Russian Federation.
FAU - Anashbaev, Zh Zh
AU  - Anashbaev ZZ
AD  - Cardiology Research Institute, Tomsk National Research Medical Centre, Russian
      Academy of Sciences, Tomsk, Russian Federation.
FAU - Popov, E V
AU  - Popov EV
AD  - Cardiology Research Institute, Tomsk National Research Medical Centre, Russian
      Academy of Sciences, Tomsk, Russian Federation.
FAU - Ryabov, V V
AU  - Ryabov VV
AD  - Cardiology Research Institute, Tomsk National Research Medical Centre, Russian
      Academy of Sciences, Tomsk, Russian Federation.
LA  - eng
PT  - Journal Article
DEP - 20210430
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of
      Nuclear Cardiology
JID - 9423534
SB  - IM
OTO - NOTNLM
OT  - Inflammation
OT  - SPECT
OT  - hybrid imaging
OT  - myocardial ischemia and infarction
OT  - tests
EDAT- 2021/05/04 06:00
MHDA- 2021/05/04 06:00
CRDT- 2021/05/03 12:45
PHST- 2021/04/01 00:00 [received]
PHST- 2021/04/01 00:00 [accepted]
PHST- 2021/05/03 12:45 [entrez]
PHST- 2021/05/04 06:00 [pubmed]
PHST- 2021/05/04 06:00 [medline]
AID - 10.1007/s12350-021-02644-4 [doi]
AID - 10.1007/s12350-021-02644-4 [pii]
PST - aheadofprint
SO  - J Nucl Cardiol. 2021 Apr 30. pii: 10.1007/s12350-021-02644-4. doi:
      10.1007/s12350-021-02644-4.