PMID- 33939163
OWN - NLM
STAT- MEDLINE
DCOM- 20230113
LR  - 20240130
IS  - 1532-6551 (Electronic)
IS  - 1071-3581 (Linking)
VI  - 29
IP  - 6
DP  - 2022 Dec
TI  - Subacute myocardial infarction detected by technetium-99m-labeled somatostatin 
      analog scintigraphy.
PG  - 3586-3589
LID - 10.1007/s12350-021-02644-4 [doi]
AB  - Recently, the applicability of somatostatin receptor-targeted (SSTR-t) 
      radiotracers for post-ischemic myocardial inflammation imaging has been shown 
      using PET. Currently, there are no studies which demonstrate ability of SPECT and 
      technetium-99m SSTR-t radiotracers to detect inflammation, which appears in 
      response to acute myocardial infarction (AMI). A case of 51-year-old male with 
      acute anterior myocardial infarction (AMI) with ST elevation has been presented. 
      This patient on 7th day after AMI onset underwent SPECT/CT (by cardiac 
      cadmium-zinc-telluride gamma-camera) with (99m)Tc-Tectrotide, cardiac MRI with 
      gadolinium and, on 9th day after AMI, myocardial perfusion scintigraphy (MPS) at 
      rest. Clear myocardial uptake of (99m)Tc-Tectrotide, predominantly in apical and 
      intermediate anterior wall of left ventricle was detected. The uptake matched 
      with areas of hypoperfusion (by SPECT) and myocardial injury (by MRI). This case 
      demonstrated the applicability of technetium-99m-labeled SSTR-t radiotracers for 
      post-infarction inflammation imaging. Currently assumed, that SSTR-t radiotracers 
      reflect an increased number of activated macrophages infiltrating infarcted 
      myocardium, which is not possible using any other imaging technique. Thus, 
      potentially, SSTR scintigraphy may be useful for diagnosis and monitoring of 
      myocardial post-infarction inflammation as well as for anti-inflammatory 
      image-guide therapy assessment.
CI  - (c) 2021. American Society of Nuclear Cardiology.
FAU - Sazonova, S I
AU  - Sazonova SI
AD  - Cardiology Research Institute, Tomsk National Research Medical Centre, Russian 
      Academy of Sciences, Tomsk, Russian Federation. sazonova_si@mail.ru.
FAU - Syrkina, A G
AU  - Syrkina AG
AD  - Cardiology Research Institute, Tomsk National Research Medical Centre, Russian 
      Academy of Sciences, Tomsk, Russian Federation.
FAU - Mochula, O V
AU  - Mochula OV
AD  - Cardiology Research Institute, Tomsk National Research Medical Centre, Russian 
      Academy of Sciences, Tomsk, Russian Federation.
FAU - Anashbaev, Zh Zh
AU  - Anashbaev ZZ
AD  - Cardiology Research Institute, Tomsk National Research Medical Centre, Russian 
      Academy of Sciences, Tomsk, Russian Federation.
FAU - Popov, E V
AU  - Popov EV
AD  - Cardiology Research Institute, Tomsk National Research Medical Centre, Russian 
      Academy of Sciences, Tomsk, Russian Federation.
FAU - Ryabov, V V
AU  - Ryabov VV
AD  - Cardiology Research Institute, Tomsk National Research Medical Centre, Russian 
      Academy of Sciences, Tomsk, Russian Federation.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20210430
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
RN  - 7440-26-8 (Technetium)
RN  - 51110-01-1 (Somatostatin)
RN  - 971Z4W1S09 (Technetium Tc 99m Sestamibi)
RN  - 0 (Receptors, Somatostatin)
SB  - IM
MH  - Male
MH  - Humans
MH  - Middle Aged
MH  - Technetium
MH  - Somatostatin
MH  - Tomography, X-Ray Computed
MH  - *Myocardial Infarction/diagnostic imaging
MH  - Radionuclide Imaging
MH  - Tomography, Emission-Computed, Single-Photon/methods
MH  - Technetium Tc 99m Sestamibi
MH  - *Myocarditis
MH  - Receptors, Somatostatin
MH  - Inflammation
OTO - NOTNLM
OT  - Inflammation
OT  - SPECT
OT  - hybrid imaging
OT  - myocardial ischemia and infarction
OT  - tests
EDAT- 2021/05/04 06:00
MHDA- 2023/01/14 06:00
CRDT- 2021/05/03 12:45
PHST- 2021/04/01 00:00 [received]
PHST- 2021/04/01 00:00 [accepted]
PHST- 2021/05/04 06:00 [pubmed]
PHST- 2023/01/14 06:00 [medline]
PHST- 2021/05/03 12:45 [entrez]
AID - S1071-3581(23)00634-7 [pii]
AID - 10.1007/s12350-021-02644-4 [doi]
PST - ppublish
SO  - J Nucl Cardiol. 2022 Dec;29(6):3586-3589. doi: 10.1007/s12350-021-02644-4. Epub 
      2021 Apr 30.