PMID- 33940070 OWN - NLM STAT- MEDLINE DCOM- 20211221 LR - 20221207 IS - 1097-6809 (Electronic) IS - 0741-5214 (Linking) VI - 74 IP - 4 DP - 2021 Oct TI - Early evaluation of the infrainguinal revascularization strategy selection tool of the Global Vascular Guidelines for chronic limb-threatening ischemia patients. PG - 1253-1260.e2 LID - S0741-5214(21)00674-1 [pii] LID - 10.1016/j.jvs.2021.04.034 [doi] AB - OBJECTIVE: The Global Vascular Guidelines (GVG) propose a novel Global Anatomic Staging System (GLASS) with the Wound, Ischemia, and foot Infection (WIfI) classification system as a clinical decision-making tool for interventions in chronic limb-threatening ischemia (CLTI). We assessed the validity of clinical staging and the relationship between the treatments recommended by the GVG and the outcomes of the actual procedures. METHODS: This retrospective, single-center, observational study included 117 patients with CLTI undergoing infrainguinal revascularization in our hospital between 2015 and 2019. Of those patients, 55 underwent open bypass (OB) and 62 underwent endovascular revascularization (EVR). Femoropopliteal, infrapopliteal, and inframalleolar GLASS grades were assigned based on angiographic images. These grades were combined to determine the revascularization strategy recommended by the GVG: "endovascular," "indeterminate," and "open bypass." The indeterminate category includes three subcategories: GLASS stage III, WIfI stage 2; GLASS stage II, WIfI stage 3; and GLASS stage II, WIfI stage 4. For the purposes of this study, we labeled these subcategories A, B, and C, respectively. The primary outcome was the correlation between the revascularization strategies recommended by the GVG and the actual procedures performed. The relationships between the actual procedures and overall survival, limb salvage, and patency were also examined. RESULTS: The femoropopliteal and infrapopliteal GLASS grades were higher in the OB group. EVR was performed more often for GLASS stages I and II and was more often classified as indeterminate B and C, whereas OB was performed more often in GLASS stage III and was more often classified as indeterminate A. There were no statistically significant differences in the inframalleolar/pedal disease descriptor or in the 30-day postoperative complication rates between the two groups. In higher GLASS stages, the technical success rate of EVR was lower, and lesion complexity was more severe. Patients for whom the recommended strategy according to the GVG would have been OB but who underwent EVR were associated with low limb salvage and patency rates. CONCLUSIONS: The GVG provide good guidance for the selection of the revascularization strategy. When the GVG indicate OB, it should be the treatment of choice, rather than EVR, for patients who are fit to undergo the procedure. CI - Copyright (c) 2021 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved. FAU - Haga, Makoto AU - Haga M AD - Department of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. Electronic address: makko420@gmail.com. FAU - Shindo, Shunya AU - Shindo S AD - Department of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Motohashi, Shinya AU - Motohashi S AD - Department of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Nishiyama, Ayako AU - Nishiyama A AD - Department of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Kimura, Mitsuhiro AU - Kimura M AD - Department of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Inoue, Hidenori AU - Inoue H AD - Department of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Akasaka, Junetsu AU - Akasaka J AD - Department of Cardiovascular Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20210501 PL - United States TA - J Vasc Surg JT - Journal of vascular surgery JID - 8407742 SB - IM MH - Aged MH - Aged, 80 and over MH - Amputation, Surgical MH - Chronic Disease MH - Clinical Decision-Making MH - *Decision Support Techniques MH - *Endovascular Procedures/adverse effects/mortality MH - Female MH - Humans MH - Ischemia/diagnosis/mortality/physiopathology/*surgery MH - Limb Salvage MH - Male MH - Middle Aged MH - Peripheral Arterial Disease/diagnosis/mortality/physiopathology/*surgery MH - Predictive Value of Tests MH - Reproducibility of Results MH - Retrospective Studies MH - Risk Assessment MH - Risk Factors MH - Time Factors MH - Treatment Outcome MH - *Vascular Grafting/adverse effects/mortality MH - Vascular Patency OTO - NOTNLM OT - Chronic limb-threatening ischemia OT - Global Anatomic Staging System OT - Global Vascular Guidelines OT - Peripheral arterial disease EDAT- 2021/05/04 06:00 MHDA- 2021/12/22 06:00 CRDT- 2021/05/03 20:12 PHST- 2020/08/17 00:00 [received] PHST- 2021/04/12 00:00 [accepted] PHST- 2021/05/04 06:00 [pubmed] PHST- 2021/12/22 06:00 [medline] PHST- 2021/05/03 20:12 [entrez] AID - S0741-5214(21)00674-1 [pii] AID - 10.1016/j.jvs.2021.04.034 [doi] PST - ppublish SO - J Vasc Surg. 2021 Oct;74(4):1253-1260.e2. doi: 10.1016/j.jvs.2021.04.034. Epub 2021 May 1.