PMID- 33941038
OWN - NLM
STAT- MEDLINE
DCOM- 20230405
LR  - 20230405
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 133
IP  - 5
DP  - 2023 May
TI  - The pleiotropic of GLP-1/GLP-1R axis in central nervous system diseases.
PG  - 473-491
LID - 10.1080/00207454.2021.1924707 [doi]
AB  - Glucagon-like peptide-1(GLP-1) is a multifunctional polypeptide throughout the 
      lifespan via activating Glucagon-like peptide-1 receptor (GLP-1R).GLP-1 can 
      affect food ingestion, enhance the secretion of insulin from pancreatic islets 
      induced by glucose and be utilized to treat type 2 diabetes mellitus(T2DM).But, 
      accumulating evidences from the decades suggest that activation GLP-1R can not 
      only regulate the blood glucose, but also sustain the homeostasis of 
      intracellular environment and protect neuron from various damaged responses such 
      as oxidative stress, inflammation, excitotoxicity, ischemia and so on. And more 
      and more pre-clinical and clinical studies identified that GLP-1 and its 
      analogues may play a significant role in improving multiple central nervous 
      system (CNS) diseases including neurodegenerative diseases, epilepsy, mental 
      disorders, ischemic stroke, hemorrhagic stroke, traumatic brain injury, spinal 
      cord injury, chronic pain, addictive disorders, other diseases neurological 
      complications and so on. In order to better reveal the relationship between 
      GLP-1/GLP-1R axis and the growth, development and survival of neurons, herein, 
      this review is aimed to summarize the multi-function of GLP-1/GLP-1R axis in CNS 
      diseases.
FAU - Zhang, LongQing
AU  - Zhang L
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Zhang, Wen
AU  - Zhang W
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
FAU - Tian, XueBi
AU  - Tian X
AUID- ORCID: 0000-0002-0624-6816
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230214
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - 0 (Glucagon-Like Peptide-1 Receptor)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Humans
MH  - Glucagon-Like Peptide 1
MH  - Glucagon-Like Peptide-1 Receptor
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - *Islets of Langerhans
MH  - *Spinal Cord Injuries/drug therapy
MH  - Transcription Factors
OTO - NOTNLM
OT  - CNS diseases
OT  - GLP-1
OT  - GLP-1R
OT  - neuroprotection
EDAT- 2021/05/05 06:00
MHDA- 2023/04/05 06:42
CRDT- 2021/05/04 05:46
PHST- 2023/04/05 06:42 [medline]
PHST- 2021/05/05 06:00 [pubmed]
PHST- 2021/05/04 05:46 [entrez]
AID - 10.1080/00207454.2021.1924707 [doi]
PST - ppublish
SO  - Int J Neurosci. 2023 May;133(5):473-491. doi: 10.1080/00207454.2021.1924707. Epub 
      2023 Feb 14.