PMID- 33943025
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20210624
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 29
IP  - 6
DP  - 2021 Jun
TI  - Association of Omental Adipocyte Hypertrophy and Fibrosis with Human Obesity and 
      Type 2 Diabetes.
PG  - 976-984
LID - 10.1002/oby.23155 [doi]
AB  - OBJECTIVE: Morphological alterations including adipocyte hypertrophy and fibrosis 
      deposition are important surrogate markers of visceral adipose tissue function, 
      but the relationships between these morphological changes and type 2 diabetes 
      mellitus (T2DM) and impaired insulin sensitivity are poorly defined. METHODS: 
      Omental adipose tissue was obtained from 66 individuals with obesity but without 
      T2DM (OB group), 93 individuals with both obesity and T2DM (T2DM group), and 15 
      individuals with normal BMI and normal glucose tolerance (NGT group). Adipocyte 
      diameter and volume were measured through pathological section analysis. 
      Pericellular and perilobular fibrosis was determined through picrosirius red 
      staining and immunochemistry, while fibrosis-related genes were tested through 
      gene expression and hydroxyproline content. RESULTS: Compared with the NGT and OB 
      groups, individuals from the T2DM group displayed increased adipocyte diameter 
      and volume levels. Increased adipocyte size (diameter and volume) was positively 
      associated with hyperglycemia and insulin resistance and inversely correlated 
      with insulin sensitivity (using the Matsuda whole-body insulin sensitivity index 
      assessment of insulin sensitivity) and beta-cell function (disposition index 30 and 
      disposition index 120). The fibrosis levels of the OB group were the highest out 
      of the three groups, whereas the fibrosis levels of T2DM individuals were lower 
      than the OB group but higher than the NGT group. Although fibrosis was negatively 
      correlated with T2DM, fibrosis deposition was not remarkably associated with 
      impaired systemic insulin sensitivity and glucose metabolism. CONCLUSIONS: 
      Compared with fibrosis deposition, adipocyte hypertrophy is more closely 
      associated with T2DM and impaired systemic insulin sensitivity.
CI  - (c) 2021 The Obesity Society.
FAU - Liu, Fangcen
AU  - Liu F
AD  - Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
AD  - Department of Pathology, Drum Tower Hospital Affiliated to Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
FAU - He, Jielei
AU  - He J
AD  - Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
FAU - Liu, Boxun
AU  - Liu B
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, China.
FAU - Zhang, Pengzi
AU  - Zhang P
AD  - Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
FAU - Wang, Hongdong
AU  - Wang H
AD  - Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
FAU - Sun, Xitai
AU  - Sun X
AD  - Department of General Surgery, Drum Tower Hospital Affiliated to Nanjing 
      University Medical School, Nanjing, Jiangsu, China.
FAU - Chu, Xuehui
AU  - Chu X
AD  - Department of General Surgery, Drum Tower Hospital Affiliated to Nanjing 
      University Medical School, Nanjing, Jiangsu, China.
FAU - Guan, Wenxian
AU  - Guan W
AD  - Department of General Surgery, Drum Tower Hospital Affiliated to Nanjing 
      University Medical School, Nanjing, Jiangsu, China.
FAU - Feng, Wenhuan
AU  - Feng W
AD  - Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
FAU - Bi, Yan
AU  - Bi Y
AUID- ORCID: 0000-0003-3914-7854
AD  - Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
FAU - Zhu, Dalong
AU  - Zhu D
AUID- ORCID: 0000-0002-1064-1261
AD  - Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University 
      Medical School, Nanjing, Jiangsu, China.
LA  - eng
SI  - ClinicalTrials.gov/NCT03296605
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210504
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
SB  - IM
MH  - Adipocytes/metabolism/pathology
MH  - Adult
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/complications/*epidemiology/metabolism/pathology
MH  - Female
MH  - Fibrosis/complications/epidemiology/metabolism
MH  - Humans
MH  - Hypertrophy/complications/epidemiology/metabolism
MH  - Insulin Resistance/physiology
MH  - Intra-Abdominal Fat/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/*epidemiology/metabolism/pathology
MH  - Omentum/*metabolism/pathology
EDAT- 2021/05/05 06:00
MHDA- 2021/06/25 06:00
CRDT- 2021/05/04 08:54
PHST- 2021/02/04 00:00 [revised]
PHST- 2020/09/03 00:00 [received]
PHST- 2021/02/07 00:00 [accepted]
PHST- 2021/05/05 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2021/05/04 08:54 [entrez]
AID - 10.1002/oby.23155 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2021 Jun;29(6):976-984. doi: 10.1002/oby.23155. Epub 
      2021 May 4.