PMID- 33944839
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20231003
IS  - 2531-6745 (Electronic)
IS  - 0392-4203 (Print)
IS  - 0392-4203 (Linking)
VI  - 92
IP  - S1
DP  - 2021 Apr 30
TI  - An uncommon case of nonconvulsive status epilepticus successfully treated with 
      enteral Brivaracetam.
PG  - e2021156
LID - 10.23750/abm.v92iS1.9649 [doi]
LID - e2021156
AB  - BACKGROUND AND AIM OF THE WORK: We present a case of a woman affected by 
      nonconvulsive status epilepticus (NCSE) caused by cerebral hyperperfusion 
      syndrome (CHS) after carotid endarterectomy (CEA) who was successfully treated 
      with Brivaracetam (BRV) administered via nasogastric tube (NGT). CASE 
      PRESENTATION: An 82-years old woman was referred for increasing blood pressure, 
      severe headache and two focal motor seizures on postoperative day four after 
      right CEA. CT scan showed edema of the right hemisphere with a midline shift of 5 
      mm. The patient underwent daily Electroencephalography (EEG) monitoring which 
      showed continuous epileptiform discharges over the right hemisphere, compatible 
      with a diagnosis of status epilepticus. She was treated with standard 
      antiepileptic drugs (Phenytoin, Lacosamide and Levetiracetam iv) without clinical 
      response. A therapeutic trial with BRV 200mg administered via nasogastric tube 
      (NGT) was tried which resulted in substantial clinical benefit. CONCLUSIONS: The 
      administration of new antiepileptic drugs (AEDs) such as BRV may result in 
      significant clinical improvement in refractory cases of status epilepticus. The 
      enteral administration of AEDs via NGT should always be considered for refractory 
      cases of status epilepticus when standard iv treatment has failed or is not 
      possible.
FAU - De Liso, Alfredo
AU  - De Liso A
AD  - Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, 
      University Campus Bio-Medico of Rome. a.deliso@unicampus.it.
FAU - Ricci, Lorenzo
AU  - Ricci L
AD  - Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, 
      University Campus Bio-Medico of Rome. lorenzo.ricci@unicampus.it.
FAU - Bravi, Maria Cristina
AU  - Bravi MC
AD  - Department of Neuroscience, Stroke Unit San Camillo Hospital, Rome. 
      mcbravi@tiscali.it.
FAU - Pezzella, Francesca Romana
AU  - Pezzella FR
AD  - Department of Neuroscience, Stroke Unit San Camillo Hospital, Rome. 
      frpezzella@gmail.com.
FAU - Anticoli, Sabrina
AU  - Anticoli S
AD  - Department of Neuroscience, Stroke Unit San Camillo Hospital, Rome. 
      sabrina.anticoli@gmail.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20210430
PL  - Italy
TA  - Acta Biomed
JT  - Acta bio-medica : Atenei Parmensis
JID - 101295064
RN  - 0 (Pyrrolidinones)
RN  - 6158TKW0C5 (Phenytoin)
RN  - U863JGG2IA (brivaracetam)
SB  - IM
MH  - Aged, 80 and over
MH  - *Electroencephalography
MH  - Female
MH  - Humans
MH  - Phenytoin
MH  - Pyrrolidinones/therapeutic use
MH  - *Status Epilepticus/drug therapy
PMC - PMC8142772
COIS- Authors have no conflicts of interest or funding to declare.
EDAT- 2021/05/05 06:00
MHDA- 2021/06/29 06:00
PMCR- 2021/01/01
CRDT- 2021/05/04 12:33
PHST- 2020/04/29 00:00 [received]
PHST- 2020/04/30 00:00 [accepted]
PHST- 2021/05/04 12:33 [entrez]
PHST- 2021/05/05 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - ACTA-92-156 [pii]
AID - 10.23750/abm.v92iS1.9649 [doi]
PST - epublish
SO  - Acta Biomed. 2021 Apr 30;92(S1):e2021156. doi: 10.23750/abm.v92iS1.9649.