PMID- 33946176
OWN - NLM
STAT- MEDLINE
DCOM- 20210526
LR  - 20210526
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 9
DP  - 2021 Apr 30
TI  - MitoQ Is Able to Modulate Apoptosis and Inflammation.
LID - 10.3390/ijms22094753 [doi]
LID - 4753
AB  - Mitoquinone (MitoQ) is a mitochondrial reactive oxygen species scavenger that is 
      characterized by high bioavailability. Prior studies have demonstrated its 
      neuroprotective potential. Indeed, the release of reactive oxygen species due to 
      damage to mitochondrial components plays a pivotal role in the pathogenesis of 
      several neurodegenerative diseases. The present study aimed to examine the impact 
      of the inflammation platform activation on the neuronal cell line (DAOY) treated 
      with specific inflammatory stimuli and whether MitoQ addition can modulate these 
      deregulations. DAOY cells were pre-treated with MitoQ and then stimulated by a 
      blockade of the cholesterol pathway, also called mevalonate pathway, using a 
      statin, mimicking cholesterol deregulation, a common parameter present in some 
      neurodegenerative and autoinflammatory diseases. To verify the role played by 
      MitoQ, we examined the expression of genes involved in the inflammation mechanism 
      and the mitochondrial activity at different time points. In this experimental 
      design, MitoQ showed a protective effect against the blockade of the mevalonate 
      pathway in a short period (12 h) but did not persist for a long time (24 and 48 
      h). The results obtained highlight the anti-inflammatory properties of MitoQ and 
      open the question about its application as an effective adjuvant for the 
      treatment of the autoinflammatory disease characterized by a cholesterol 
      deregulation pathway that involves mitochondrial homeostasis.
FAU - Piscianz, Elisa
AU  - Piscianz E
AUID- ORCID: 0000-0001-7374-1684
AD  - Hygiene and Public Health Unit (ASUGI), 34129 Trieste, Italy.
FAU - Tesser, Alessandra
AU  - Tesser A
AUID- ORCID: 0000-0001-6267-3794
AD  - Department of Pediatrics, Institute for Maternal and Child Health-IRCCS Burlo 
      Garofolo, 34137 Trieste, Italy.
FAU - Rimondi, Erika
AU  - Rimondi E
AD  - Department of Translational Medicine and LTTA Centre, University of Ferrara, 
      44121 Ferrara, Italy.
FAU - Melloni, Elisabetta
AU  - Melloni E
AUID- ORCID: 0000-0002-7829-0824
AD  - Department of Translational Medicine and LTTA Centre, University of Ferrara, 
      44121 Ferrara, Italy.
FAU - Celeghini, Claudio
AU  - Celeghini C
AD  - Department of Translational Medicine, University of Ferrara, 44121 Ferrara, 
      Italy.
FAU - Marcuzzi, Annalisa
AU  - Marcuzzi A
AD  - Department of Translational Medicine, University of Ferrara, 44121 Ferrara, 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20210430
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Reactive Oxygen Species)
RN  - 1339-63-5 (Ubiquinone)
RN  - 47BYS17IY0 (mitoquinone)
SB  - IM
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Apoptosis/*drug effects
MH  - Cell Line
MH  - Free Radical Scavengers/*pharmacology
MH  - Humans
MH  - Inflammation/*drug therapy/metabolism
MH  - Mitochondria/metabolism
MH  - Neurons/cytology/drug effects/metabolism
MH  - Organophosphorus Compounds/*pharmacology
MH  - Reactive Oxygen Species/metabolism
MH  - Ubiquinone/*analogs & derivatives/pharmacology
PMC - PMC8124358
OTO - NOTNLM
OT  - autophagy
OT  - cholesterol
OT  - cytokines
OT  - inflammation
OT  - mitochondria
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/06 06:00
MHDA- 2021/05/27 06:00
PMCR- 2021/04/30
CRDT- 2021/05/05 01:01
PHST- 2021/03/30 00:00 [received]
PHST- 2021/04/25 00:00 [revised]
PHST- 2021/04/27 00:00 [accepted]
PHST- 2021/05/05 01:01 [entrez]
PHST- 2021/05/06 06:00 [pubmed]
PHST- 2021/05/27 06:00 [medline]
PHST- 2021/04/30 00:00 [pmc-release]
AID - ijms22094753 [pii]
AID - ijms-22-04753 [pii]
AID - 10.3390/ijms22094753 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Apr 30;22(9):4753. doi: 10.3390/ijms22094753.