PMID- 33946541
OWN - NLM
STAT- MEDLINE
DCOM- 20210527
LR  - 20240402
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 9
DP  - 2021 Apr 30
TI  - MicroRNAs in Acute ST Elevation Myocardial Infarction-A New Tool for Diagnosis 
      and Prognosis: Therapeutic Implications.
LID - 10.3390/ijms22094799 [doi]
LID - 4799
AB  - Despite diagnostic and therapeutic advances, coronary artery disease and 
      especially its extreme manifestation, ST elevation myocardial infarction (STEMI), 
      remain the leading causes of morbidity and mortality worldwide. Early and prompt 
      diagnosis is of great importance regarding the prognosis of STEMI patients. In 
      recent years, microRNAs (miRNAs) have emerged as promising tools involved in many 
      pathophysiological processes in various fields, including cardiovascular 
      diseases. In acute coronary syndromes (ACS), circulating levels of miRNAs are 
      significantly elevated, as an indicator of cardiac damage, making them a 
      promising marker for early diagnosis of myocardial infarction. They also have 
      prognostic value and great potential as therapeutic targets considering their key 
      function in gene regulation. This review aims to summarize current information 
      about miRNAs and their role as diagnostic, prognostic and therapeutic targets in 
      STEMI patients.
FAU - Scarlatescu, Alina Ioana
AU  - Scarlatescu AI
AUID- ORCID: 0000-0003-2183-5771
AD  - Department of Cardiology, "Carol Davila" University of Medicine and Pharmacy, 
      050474 Bucharest, Romania.
AD  - Department of Cardiology, Clinical Emergency Hospital of Bucharest, 014461 
      Bucharest, Romania.
FAU - Micheu, Miruna Mihaela
AU  - Micheu MM
AUID- ORCID: 0000-0001-7201-3132
AD  - Department of Cardiology, Clinical Emergency Hospital of Bucharest, 014461 
      Bucharest, Romania.
FAU - Popa-Fotea, Nicoleta-Monica
AU  - Popa-Fotea NM
AUID- ORCID: 0000-0002-8066-5779
AD  - Department of Cardiology, "Carol Davila" University of Medicine and Pharmacy, 
      050474 Bucharest, Romania.
AD  - Department of Cardiology, Clinical Emergency Hospital of Bucharest, 014461 
      Bucharest, Romania.
FAU - Dorobantu, Maria
AU  - Dorobantu M
AD  - Department of Cardiology, "Carol Davila" University of Medicine and Pharmacy, 
      050474 Bucharest, Romania.
AD  - Department of Cardiology, Clinical Emergency Hospital of Bucharest, 014461 
      Bucharest, Romania.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210430
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biomarkers)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood
MH  - Humans
MH  - MicroRNAs/blood/*genetics
MH  - Prognosis
MH  - ST Elevation Myocardial Infarction/blood/diagnosis/*genetics/physiopathology
MH  - Up-Regulation
PMC - PMC8124280
OTO - NOTNLM
OT  - STEMI
OT  - biomarkers
OT  - miRNA
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2021/05/06 06:00
MHDA- 2021/05/28 06:00
PMCR- 2021/04/30
CRDT- 2021/05/05 01:02
PHST- 2021/03/15 00:00 [received]
PHST- 2021/04/23 00:00 [revised]
PHST- 2021/04/26 00:00 [accepted]
PHST- 2021/05/05 01:02 [entrez]
PHST- 2021/05/06 06:00 [pubmed]
PHST- 2021/05/28 06:00 [medline]
PHST- 2021/04/30 00:00 [pmc-release]
AID - ijms22094799 [pii]
AID - ijms-22-04799 [pii]
AID - 10.3390/ijms22094799 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Apr 30;22(9):4799. doi: 10.3390/ijms22094799.