PMID- 33946836
OWN - NLM
STAT- MEDLINE
DCOM- 20210525
LR  - 20210525
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 18
IP  - 9
DP  - 2021 Apr 29
TI  - Analysis of Medication Adherence and Its Influencing Factors in Patients with 
      Schizophrenia in the Chinese Institutional Environment.
LID - 10.3390/ijerph18094746 [doi]
LID - 4746
AB  - BACKGROUND: Factors related to medication adherence in patients with 
      schizophrenia have always been key to the treatment and rehabilitation of these 
      patients. However, the treatment modes in different countries are not the same, 
      and there is no research on the factors influencing medication adherence under 
      different mental health service modes. OBJECTIVES: The purpose of this study was 
      to explore medication adherence and its influencing factors in patients with 
      schizophrenia in the Chinese institutional environment. METHODS: We conducted a 
      cross-sectional study of hospitalized persons living with schizophrenia from 
      November 2018 to January 2019. A systematic sampling method was used to select 
      217 hospitalized persons living with schizophrenia. The Medication Adherence 
      Rating Scale (MARS), Positive and Negative Syndrome Scale (PANSS), General 
      Self-Efficacy Scale (GSES), Schizophrenia Quality of Life Scale (SQLS), and Scale 
      of Social Skills for Psychiatric Inpatients (SSPI) were used to explore 
      medication compliance and its influencing factors in the Chinese institutional 
      environment. RESULTS: The descriptive analysis and ANOVA showed that there were 
      no significant differences in medication adherence when assessed by demographic 
      characteristics such as sex, marital status, and education level (p > 0.05). A 
      correlation analysis showed that there was no significant correlation between 
      medication adherence and mental symptoms (p > 0.05) but that there was a positive 
      correlation with self-efficacy, quality of life, and activities of daily living 
      (p < 0.01). The linear regression analysis showed that self-efficacy, 
      psychosocial factors, symptoms/side effects, and activities of daily living had 
      significant effects on medication adherence (F = 30.210, p < 0.001). CONCLUSIONS: 
      Our findings show that the self-efficacy, quality of life, and social function of 
      patients with schizophrenia are important self-factors influencing medication 
      adherence in the Chinese institutional environment.
FAU - Yu, Wei
AU  - Yu W
AD  - Shanghai Pudong New Area Mental Health Center, Tongji University School of 
      Medicine, 165 Sanlin Road, Shanghai 200124, China.
FAU - Tong, Jie
AU  - Tong J
AD  - Shanghai Pudong New Area Mental Health Center, Tongji University School of 
      Medicine, 165 Sanlin Road, Shanghai 200124, China.
FAU - Sun, Xirong
AU  - Sun X
AD  - Shanghai Pudong New Area Mental Health Center, Tongji University School of 
      Medicine, 165 Sanlin Road, Shanghai 200124, China.
FAU - Chen, Fazhan
AU  - Chen F
AD  - Shanghai Pudong New Area Mental Health Center, Tongji University School of 
      Medicine, 165 Sanlin Road, Shanghai 200124, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Shanghai Pudong New Area Mental Health Center, Tongji University School of 
      Medicine, 165 Sanlin Road, Shanghai 200124, China.
FAU - Pei, Yu
AU  - Pei Y
AD  - Shanghai Pudong New Area Mental Health Center, Tongji University School of 
      Medicine, 165 Sanlin Road, Shanghai 200124, China.
FAU - Zhang, Tingting
AU  - Zhang T
AD  - Shanghai Pudong New Area Mental Health Center, Tongji University School of 
      Medicine, 165 Sanlin Road, Shanghai 200124, China.
FAU - Zhang, Jiechun
AU  - Zhang J
AD  - Shanghai Pudong New Area Mental Health Center, Tongji University School of 
      Medicine, 165 Sanlin Road, Shanghai 200124, China.
FAU - Zhu, Binggen
AU  - Zhu B
AUID- ORCID: 0000-0002-5174-6932
AD  - Shanghai Pudong New Area Mental Health Center, Tongji University School of 
      Medicine, 165 Sanlin Road, Shanghai 200124, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210429
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Activities of Daily Living
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Medication Adherence
MH  - Quality of Life
MH  - *Schizophrenia/drug therapy/epidemiology
PMC - PMC8125059
OTO - NOTNLM
OT  - Chinese
OT  - influencing factors
OT  - institutional environment
OT  - medication adherence
OT  - schizophrenia
COIS- The authors report no conflict of interest related to this work.
EDAT- 2021/05/06 06:00
MHDA- 2021/05/26 06:00
PMCR- 2021/04/29
CRDT- 2021/05/05 01:03
PHST- 2021/03/11 00:00 [received]
PHST- 2021/04/20 00:00 [revised]
PHST- 2021/04/25 00:00 [accepted]
PHST- 2021/05/05 01:03 [entrez]
PHST- 2021/05/06 06:00 [pubmed]
PHST- 2021/05/26 06:00 [medline]
PHST- 2021/04/29 00:00 [pmc-release]
AID - ijerph18094746 [pii]
AID - ijerph-18-04746 [pii]
AID - 10.3390/ijerph18094746 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Apr 29;18(9):4746. doi: 
      10.3390/ijerph18094746.