PMID- 33947230
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220531
IS  - 1816-5370 (Electronic)
IS  - 0218-4923 (Linking)
VI  - 30
IP  - 2
DP  - 2022 Feb
TI  - Sex-stratified outcomes of primary percutaneous coronary intervention: A tertiary 
      care experience.
PG  - 164-170
LID - 10.1177/02184923211014001 [doi]
AB  - BACKGROUND: ST elevation myocardial infarction (STEMI) is an acute cardiac 
      manifestation that requires immediate revascularization preferably through 
      primary percutaneous coronary intervention (PCI). This study aims to describe 
      gender stratified outcomes and epidemiological profile of STEMI patients 
      undergoing treatment at a tertiary care hospital in Karachi, Pakistan. METHODS: A 
      5-year, retrospective analysis of hospital records was undertaken on confirmed 
      STEMI patients admitted between 2010 and 2014, undergoing primary PCI. 
      Information was retrieved on demographic variables, risk factors, total ischemia 
      time, door to balloon time, angiographic findings, and treatment strategy and 
      in-hospital outcomes. RESULTS: A total of 603 patients were available for 
      analysis. Mean age of the participants was 58 +/- 11 years, with 78.6% being males. 
      The most common risk factors were hypertension (48.1%), diabetes (37%), and 
      smoking (22.2%). Gender stratified analysis revealed poorer clinical presentation 
      and prolonged ischemia time among women when compared to men (410 vs. 310 min, 
      respectively). Total in-hospital mortality was 9.6% and was higher in women 
      (19.3%), patients with non-anterior infarction (12%), Killip class >2 (39%), 
      advanced age (14.6%), and multi-vessel disease (12%). CONCLUSION: Our study 
      describes the common risk factors and treatment outcomes for STEMI patients 
      undergoing primary PCI at a tertiary care hospital in Karachi. In-hospital 
      mortality and total ischemia time were higher among women compared to men in our 
      study. Moreover, the risk profile, treatment related complications, and outcomes 
      were poorer in women compared to men. We suggest further research to investigate 
      the effect of prolonged ischemia time on long-term clinical outcomes.
FAU - Artani, Azmina
AU  - Artani A
AD  - Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
FAU - Baloch, Farhala
AU  - Baloch F
AD  - Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
FAU - Laghari, Abid
AU  - Laghari A
AD  - Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
FAU - Siddiqui, Faraz
AU  - Siddiqui F
AD  - Department of Health Sciences, University of York, Heslington, United Kingdom.
FAU - Artani, Moiz
AU  - Artani M
AD  - Jinnah Medical and Dental College, Karachi, Pakistan.
FAU - Kazmi, Khawar
AU  - Kazmi K
AUID- ORCID: 0000-0002-5805-6408
AD  - Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
LA  - eng
PT  - Journal Article
DEP - 20210504
PL  - England
TA  - Asian Cardiovasc Thorac Ann
JT  - Asian cardiovascular & thoracic annals
JID - 9503417
SB  - IM
MH  - Aged
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pakistan/epidemiology
MH  - *Percutaneous Coronary Intervention
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *ST Elevation Myocardial Infarction/diagnostic 
      imaging/epidemiology/surgery/therapy
MH  - Sex Factors
MH  - Tertiary Healthcare
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Myocardial infarction
OT  - ST elevation myocardial infarction
OT  - in-hospital mortality
OT  - myocardial ischemia
OT  - percutaneous coronary intervention
EDAT- 2021/05/06 06:00
MHDA- 2022/04/09 06:00
CRDT- 2021/05/05 05:31
PHST- 2021/05/06 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
PHST- 2021/05/05 05:31 [entrez]
AID - 10.1177/02184923211014001 [doi]
PST - ppublish
SO  - Asian Cardiovasc Thorac Ann. 2022 Feb;30(2):164-170. doi: 
      10.1177/02184923211014001. Epub 2021 May 4.