PMID- 33947339
OWN - NLM
STAT- MEDLINE
DCOM- 20210601
LR  - 20220422
IS  - 1471-2334 (Electronic)
IS  - 1471-2334 (Linking)
VI  - 21
IP  - 1
DP  - 2021 May 4
TI  - HLA-G polymorphism impacts the outcome of oral HPV infections in women.
PG  - 419
LID - 10.1186/s12879-021-06079-7 [doi]
LID - 419
AB  - BACKROUND: Human leukocyte antigen (HLA)-G may have an important role in the 
      natural history of human papillomavirus (HPV) infection. Our aim was to evaluate 
      the role of HLA-G in the outcome of genital and oral HPV infections in women. 
      METHODS: Analyses included 306 women from the Finnish Family HPV-study and were 
      followed-up for six years. Genital and oral samples were tested for 24 different 
      HPV types with multiplex HPV genotyping. HLA-G alleles were determined through 
      direct DNA-sequencing. Unconditional logistic regression was used to determine 
      the associations between HLA-G genotypes and HPV infection outcomes. RESULTS: Ten 
      HLA-G alleles were identified. Most common HLA-G genotypes were the wild type 
      G*01:01:01/01:01:01 (31.3%) followed by G*01:01:01/01:01:02 (26.8%). 
      G*01:01:01/01:01:01 genotype was associated with increased risk of oral HPV 
      infections by any HPV type or single-type with OR = 1.86 (95% CI 1.14-3.04, 
      P = 0.01) and 2.22 (95% CI 1.14-3.71, P = 0.02), respectively. G*04:01+ allele 
      and the G*01:01:01/01:04:01 genotype both protected from any and single oral HPV 
      infections; OR = 0.46 (95% CI 0.23-0.89, P = 0.02) and 0.53 (95% CI 0.23-0.97, 
      P = 0.03), respectively. G*01:01:02/01:04:01 genotype increased significantly the 
      risk of infertility and its treatments, with respective OR = 5.06 (95% CI 
      1.22-21.02, P = 0.03) and OR = 9.07 (95% CI 1.22-39.50, P = 0.03). Both HLA-G 
      alleles and genotypes showed several significant associations with the outcomes 
      of oral HPV infections, but none of them had any impact on the outcomes of 
      genital HPV infections in these women. CONCLUSIONS: The host HLA-G genotypes 
      appear to impact the outcomes of oral HPV infections in women but have little if 
      any effect on genital HPV status or infection outcomes.
FAU - Jaakola, Anna
AU  - Jaakola A
AUID- ORCID: 0000-0001-5549-5280
AD  - Turku University Hospital, University of Turku, Turku, Finland. ajjaak@utu.fi.
AD  - Department of Obstetrics and Gynecology, Kymenlaakso Central Hospital, Kotkantie 
      41, 48210, Kotka, Finland. ajjaak@utu.fi.
FAU - Roger, Michel
AU  - Roger M
AD  - Centre de Recherche du CHUM, Montreal, Canada.
AD  - Departement de Microbiologie, Infectiologie et Immunologie,de l'Universite de 
      Montreal, Montreal, Canada.
FAU - Faucher, Marie-Claude
AU  - Faucher MC
AD  - Centre de Recherche du CHUM, Montreal, Canada.
FAU - Syrjanen, Kari
AU  - Syrjanen K
AD  - Department of Clinical Research, Biohit Oyj, Helsinki, Finland.
FAU - Grenman, Seija
AU  - Grenman S
AD  - Turku University Hospital, University of Turku, Turku, Finland.
FAU - Syrjanen, Stina
AU  - Syrjanen S
AD  - Department of Oral Pathology and Radiology, University of Turku, Turku, Finland.
AD  - Department of Pathology, Turku University Hospital, University of Turku, Turku, 
      Finland.
FAU - Louvanto, Karolina
AU  - Louvanto K
AD  - Department of Oral Pathology and Radiology, University of Turku, Turku, Finland.
AD  - Department of Obstetrics and Gynecology, Tampere University and Tampere 
      University Hospital, Tampere, Finland.
LA  - eng
PT  - Journal Article
DEP - 20210504
PL  - England
TA  - BMC Infect Dis
JT  - BMC infectious diseases
JID - 100968551
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Female
MH  - Finland
MH  - Genotype
MH  - HLA-G Antigens/*genetics
MH  - Humans
MH  - Infertility, Female/genetics/virology
MH  - Male
MH  - Middle Aged
MH  - Mouth Diseases/*virology
MH  - Mouth Mucosa/virology
MH  - Papillomaviridae/genetics
MH  - Papillomavirus Infections/*genetics/virology
MH  - *Polymorphism, Genetic
MH  - Pregnancy
MH  - Sequence Analysis, DNA
MH  - Young Adult
PMC - PMC8097798
OTO - NOTNLM
OT  - Genotype
OT  - HLA-G
OT  - HPV
OT  - Human papilloma virus
OT  - Infection
OT  - Oral
COIS- Nothing to declare.
EDAT- 2021/05/06 06:00
MHDA- 2021/06/02 06:00
PMCR- 2021/05/04
CRDT- 2021/05/05 05:36
PHST- 2021/02/08 00:00 [received]
PHST- 2021/04/15 00:00 [accepted]
PHST- 2021/05/05 05:36 [entrez]
PHST- 2021/05/06 06:00 [pubmed]
PHST- 2021/06/02 06:00 [medline]
PHST- 2021/05/04 00:00 [pmc-release]
AID - 10.1186/s12879-021-06079-7 [pii]
AID - 6079 [pii]
AID - 10.1186/s12879-021-06079-7 [doi]
PST - epublish
SO  - BMC Infect Dis. 2021 May 4;21(1):419. doi: 10.1186/s12879-021-06079-7.