PMID- 33948909
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210825
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 12
IP  - 9
DP  - 2021 Sep
TI  - Cost Analysis of FreeStyle Libre((R)) 2 System in Type 2 Diabetes Mellitus 
      Population.
PG  - 2329-2342
LID - 10.1007/s13300-021-01064-4 [doi]
AB  - INTRODUCTION: FreeStyle Libre((R)) 2 system is a sensor-based flash-monitoring 
      system that measures interstitial fluid glucose. The study aimed to compare cost 
      of FreeStyle Libre 2 system and self-monitoring of blood glucose (SMBG) in the 
      type 2 diabetes mellitus (T2DM) population from the Spanish Health System 
      perspective. METHODS: On the basis of data collected from a literature review, 
      the cost of glucose monitoring was modelled for patients with T2DM on a 
      basal-bolus insulin regimen. The cost estimate included annual consumption for 
      glucose monitoring (strips, lancets and sensors) and severe hypoglycaemic events 
      (SHE) management. A published rate of SHE (2.5 episodes/patient-year) was 
      considered. A reduction of SHE (- 48.8%) associated with FreeStyle Libre 2 
      system, derived from the REPLACE trial, was applied. Hospital attendance for 
      20.5% of SHEs (with subsequent hospitalization in 16.0%) was applied. Consumption 
      of strips and lancets was set at 6/day for SMBG (derived from national monitoring 
      recommendations), and 0.2/day for FreeStyle Libre 2 system users, with 
      26 FreeStyle Libre 2 sensors/year. Unitary costs (euro, year 2020 excluding VAT) 
      were derived from literature (euro0.28/strip; euro0.09/lancet; euro3.09/daily FM sensor; 
      euro3804/hospitalized SHE; euro1794/hospital-attended non-admitted SHE; 
      euro389/community-attended SHE). RESULTS: Costs were euro2700 and euro2120/year/patient 
      using SMBG or FreeStyle Libre 2 system, respectively. For 1000 patients with T2DM 
      using basal-bolus insulin, 1220 SHEs/year (with 48 hospitalizations) could be 
      prevented and FreeSytle Libre 2 system could generate cost savings of up to 
      euro580,953/year versus SMBG (- 21.5%). CONCLUSION: FreeStyle Libre 2 system is a 
      potential cost-saving strategy in patients with T2DM in Spain on a basal-bolus 
      insulin regimen.
CI  - (c) 2021. The Author(s).
FAU - Oyaguez, Itziar
AU  - Oyaguez I
AUID- ORCID: 0000-0002-3047-6152
AD  - Pharmacoeconomics and Outcomes Research Iberia (PORIB), Paseo Joaquin Rodrigo 4 - 
      letra I, Pozuelo de Alarcon, 28224, Madrid, Spain. ioyaguez@porib.com.
FAU - Gomez-Peralta, Fernando
AU  - Gomez-Peralta F
AD  - Unidad de Endocrinologia y Nutricion, Hospital General de Segovia, Segovia, 
      Spain.
FAU - Artola, Sara
AU  - Artola S
AD  - Centro de Salud Jose Marva, Madrid, Spain.
FAU - Carrasco, Francisco J
AU  - Carrasco FJ
AD  - UGC Medicina Interna, Hospital Universitario Juan Ramon Jimenez, Huelva, Spain.
FAU - Carretero-Gomez, Juana
AU  - Carretero-Gomez J
AD  - Servicio de Medicina Interna, Hospital de Zafra, Badajoz, Spain.
FAU - Garcia-Soidan, Javier
AU  - Garcia-Soidan J
AD  - Porrino Primary Care Centre, Pontevedra, Spain.
FAU - Gomez-Huelgas, Ricardo
AU  - Gomez-Huelgas R
AD  - Servicio de Medicina Interna, Hospital Regional Universitario de Malaga, 
      Instituto de Investigacion Biomedica de Malaga (IBIMA), Universidad de Malaga; 
      and Ciber Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de 
      Salud Carlos III, Madrid, Spain.
FAU - Merino-Torres, Juan F
AU  - Merino-Torres JF
AD  - Endocrinologia y Nutricion, Departamento Medicina, Hospital Universitario y 
      Politecnico La Fe, Universitat de Valencia, Valencia, Spain.
FAU - Perez, Antonio
AU  - Perez A
AUID- ORCID: 0000-0001-5528-1143
AD  - Servicio de Endocrinologia y Nutricion. Hospital de la Santa Creu i Sant Pau, 
      IIB-Sant Pau, CIBERDEM, Universitat Autonoma de Barcelona, Barcelona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20210504
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
EIN - Diabetes Ther. 2021 Jul 9;:. PMID: 34241813
PMC - PMC8096131
OTO - NOTNLM
OT  - Cost
OT  - Diabetes
OT  - Flash
OT  - FreeStyle Libre
OT  - Glucose monitoring
EDAT- 2021/05/06 06:00
MHDA- 2021/05/06 06:01
PMCR- 2021/05/04
CRDT- 2021/05/05 06:38
PHST- 2021/03/09 00:00 [received]
PHST- 2021/04/20 00:00 [accepted]
PHST- 2021/05/06 06:00 [pubmed]
PHST- 2021/05/06 06:01 [medline]
PHST- 2021/05/05 06:38 [entrez]
PHST- 2021/05/04 00:00 [pmc-release]
AID - 10.1007/s13300-021-01064-4 [pii]
AID - 1064 [pii]
AID - 10.1007/s13300-021-01064-4 [doi]
PST - ppublish
SO  - Diabetes Ther. 2021 Sep;12(9):2329-2342. doi: 10.1007/s13300-021-01064-4. Epub 
      2021 May 4.