PMID- 33949152
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20210622
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Linking)
VI  - 10
IP  - 11
DP  - 2021 Jun
TI  - 3D Printing Unique Nanoclay-Incorporated Double-Network Hydrogels for 
      Construction of Complex Tissue Engineering Scaffolds.
PG  - e2100036
LID - 10.1002/adhm.202100036 [doi]
AB  - The development of new biomaterial inks with good structural formability and 
      mechanical strength is critical to the fabrication of 3D tissue engineering 
      scaffolds. For extrusion-based 3D printing, the resulting 3D constructs are 
      essentially a sequential assembly of 1D filaments into 3D constructs. Inspired by 
      this process, this paper reports the recent study on 3D printing of 
      nanoclay-incorporated double-network (NIDN) hydrogels for the fabrication of 1D 
      filaments and 3D constructs without extra assistance of support bath. The 
      frequently used "house-of-cards" architectures formed by nanoclay are 
      disintegrated in the NIDN hydrogels. However, nanoclay can act as physical 
      crosslinkers to interact with polymer chains of methacrylated hyaluronic acid 
      (HAMA) and alginate (Alg), which endows the hydrogel precursors with good 
      structural formability. Various straight filaments, spring-like loops, and 
      complex 3D constructs with high shape-fidelity and good mechanical strength are 
      fabricated successfully. In addition, the NIDN hydrogel system can easily be 
      transformed into a new type of magnetic responsive hydrogel used for 3D printing. 
      The NIDN hydrogels also supported the growth of bone marrow mesenchymal stem 
      cells and displayed potential calvarial defect repair functions.
CI  - (c) 2021 Wiley-VCH GmbH.
FAU - Guo, Zhongwei
AU  - Guo Z
AD  - Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 
      518055, China.
AD  - Precision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen 
      Institute, Tsinghua University, Shenzhen, 518055, China.
FAU - Dong, Lina
AU  - Dong L
AD  - Precision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen 
      Institute, Tsinghua University, Shenzhen, 518055, China.
FAU - Xia, Jingjing
AU  - Xia J
AD  - Department of Mechanical Engineering and Mechanics, Tsinghua University, Beijing, 
      100084, China.
FAU - Mi, Shengli
AU  - Mi S
AD  - Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 
      518055, China.
FAU - Sun, Wei
AU  - Sun W
AUID- ORCID: 0000-0002-3370-2098
AD  - Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 
      518055, China.
AD  - Precision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen 
      Institute, Tsinghua University, Shenzhen, 518055, China.
AD  - Department of Mechanical Engineering and Mechanics, Tsinghua University, Beijing, 
      100084, China.
AD  - Department of Mechanical Engineering, Drexel University, Philadelphia, PA, 19104, 
      United States.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210505
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 0 (Hydrogels)
SB  - IM
MH  - *Bioprinting
MH  - Hydrogels
MH  - Printing, Three-Dimensional
MH  - *Tissue Engineering
MH  - Tissue Scaffolds
OTO - NOTNLM
OT  - 3D printing
OT  - double-network hydrogels
OT  - nanoclays
OT  - nanocomposite hydrogels
OT  - tissue engineering scaffolds
EDAT- 2021/05/06 06:00
MHDA- 2021/06/23 06:00
CRDT- 2021/05/05 06:55
PHST- 2021/03/26 00:00 [revised]
PHST- 2021/01/07 00:00 [received]
PHST- 2021/05/06 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2021/05/05 06:55 [entrez]
AID - 10.1002/adhm.202100036 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2021 Jun;10(11):e2100036. doi: 10.1002/adhm.202100036. Epub 
      2021 May 5.