PMID- 33949348
OWN - NLM
STAT- MEDLINE
DCOM- 20210910
LR  - 20210910
IS  - 1078-7496 (Print)
IS  - 1078-7496 (Linking)
VI  - 28
IP  - 3
DP  - 2021 May-Jun 01
TI  - Hemodynamic Adverse Effects of Dexmedetomidine and Propofol in a Critically Ill 
      Trauma and Surgical Population: A Retrospective Cohort.
PG  - 149-158
LID - 10.1097/JTN.0000000000000576 [doi]
AB  - BACKGROUND: Propofol and dexmedetomidine may cause hemodynamic adverse effects 
      (AEs) and more data are needed in a trauma and surgical population. OBJECTIVE: 
      The objective of this study was to evaluate the rate of hemodynamic AEs requiring 
      an intervention between dexmedetomidine and propofol in a critically ill trauma 
      and surgical population. METHODS: This was a retrospective cohort study at a 
      Level 1 trauma center. Intensive care unit patients admitted from October 1, 
      2017, through October 31, 2018, were divided into two groups: dexmedetomidine or 
      propofol. The primary end point was the proportion of patients who required a 
      therapeutic intervention for a hemodynamic AE within the first 24 hr of 
      initiation of dexmedetomidine or propofol. RESULTS: A total of 800 charts were 
      reviewed and 85 patients (dexmedetomidine [n = 35] and propofol [n = 50]) were 
      included. The study population consisted of Caucasian (86%) males (61%) with a 
      median age of 61 [interquartile range-IQR 48, 72], and 18% and 24% required 
      antihypertensive and vasopressor agents, respectively. No difference in the 
      primary outcome was observed (17 [49%] vs. 27 [54%], p = .624). There was no 
      difference in the overall incidence of hemodynamic AE (18 [51%] vs. 30 [60%], p = 
      .433). Dexmedetomidine patients had a greater decrease in median heart rate (HR) 
      compared with the propofol (23 [IQR 16, 41] vs. 14 [IQR 5, 24] beats/min, p = 
      .002). CONCLUSIONS: The rate of hemodynamic AEs requiring therapeutic 
      interventions was similar between dexmedetomidine and propofol in a critically 
      ill trauma and surgical population; however, dexmedetomidine may be associated 
      with a larger decrease in HR.
CI  - Copyright (c) 2021 Society of Trauma Nurses.
FAU - Nicholson, Carli R
AU  - Nicholson CR
AD  - Department of Pharmacy, Cleveland Clinic Akron General, Akron, Ohio.
FAU - Mullen, Chanda
AU  - Mullen C
FAU - Frazee, Lawrence A
AU  - Frazee LA
FAU - Cucci, Michaelia D
AU  - Cucci MD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Trauma Nurs
JT  - Journal of trauma nursing : the official journal of the Society of Trauma Nurses
JID - 9512997
RN  - 0 (Hypnotics and Sedatives)
RN  - 67VB76HONO (Dexmedetomidine)
RN  - YI7VU623SF (Propofol)
MH  - Aged
MH  - Critical Illness
MH  - Dexmedetomidine/pharmacology
MH  - Female
MH  - *Hemodynamics/drug effects
MH  - Humans
MH  - Hypnotics and Sedatives/pharmacology
MH  - Male
MH  - Middle Aged
MH  - Propofol/pharmacology
MH  - Retrospective Studies
COIS- The authors declare no conflicts of interest.
EDAT- 2021/05/06 06:00
MHDA- 2021/09/11 06:00
CRDT- 2021/05/05 09:00
PHST- 2021/05/05 09:00 [entrez]
PHST- 2021/05/06 06:00 [pubmed]
PHST- 2021/09/11 06:00 [medline]
AID - 00043860-202105000-00003 [pii]
AID - 10.1097/JTN.0000000000000576 [doi]
PST - ppublish
SO  - J Trauma Nurs. 2021 May-Jun 01;28(3):149-158. doi: 10.1097/JTN.0000000000000576.