PMID- 33951124
OWN - NLM
STAT- MEDLINE
DCOM- 20220114
LR  - 20220114
IS  - 1842-1121 (Electronic)
IS  - 1841-8724 (Linking)
VI  - 30
IP  - 2
DP  - 2021 Jun 18
TI  - Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors 
      Affecting their Efficacy. A Prospective, Randomized Study.
PG  - 213-220
LID - 10.15403/jgld-3401 [doi]
AB  - BACKGROUND AND AIMS: Adequate bowel preparation is essential for successful and 
      effective colonoscopy. Several types of cleansing agents are currently available 
      including low-volume solutions. The aim of this study was to compare the efficacy 
      of four different bowel cleansing agents. METHODS: A single-center, prospective, 
      randomized, and single-blind study was performed. Consecutive patients referred 
      for colonoscopy were enrolled and randomized into one of the following types of 
      laxatives: polyethylenglycol 4L (PEG), oral sulfate solution (OSS), 2L 
      polyethylenglycol + ascorbate (2L-PEG/Asc), or magnesium citrate + sodium 
      picosulfate (MCSP). The primary outcome was quality of bowel cleansing evaluated 
      according to the Boston Bowel Preparation Scale (BBPS). Secondary outcomes were 
      polyp detection rate (PDR) and tolerability. RESULTS: Final analysis was 
      performed on 431 patients. The number of patients with adequate bowel preparation 
      (BBPS total scores >/=6 and sub scores >/=2 in each segment) was not significantly 
      different throughout all groups (95.4% PEG; 94.6% OSS; 96.3% 2L-PEG/Asc; 96.2% 
      MCSP; p=0.955). Excellent bowel preparation (BBPS total scores >/= 8) was 
      associated with younger age (p=0.007). The groups did not have significantly 
      different PDRs (49.5% PEG; 49.1% OSS; 38% 2L-PEG/Asc; 40.4% MCSP; p=0.201). The 
      strongest predictors of pathology identification were age and male gender. The 
      best-tolerated solution was MCSP (palatability: p<0.001; nausea: p=0.024).
FAU - Kmochova, Klara
AU  - Kmochova K
AD  - Department of Medicine, 1st Faculty of Medicine, Charles University and Military 
      University Hospital, Prague, Czech Republic. . klara.kmochova@uvn.cz.
FAU - Grega, Tomas
AU  - Grega T
AD  - Department of Medicine, 1st Faculty of Medicine, Charles University and Military 
      University Hospital, Prague, Czech Republic. tomas.grega@uvn.cz.
FAU - Ngo, Ondrej
AU  - Ngo O
AD  - Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, 
      Brno, Czech Republic. ngo@iba.muni.cz.
FAU - Vojtechova, Gabriela
AU  - Vojtechova G
AD  - Department of Medicine, 1st Faculty of Medicine, Charles University and Military 
      University Hospital, Prague, Czech Republic. gabriela.vojtechova@uvn.cz.
FAU - Majek, Ondrej
AU  - Majek O
AD  - Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, 
      Brno, Czech Republic. majek@iba.muni.cz.
FAU - Urbanek, Petr
AU  - Urbanek P
AD  - Department of Medicine, 1st Faculty of Medicine, Charles University and Military 
      University Hospital, Prague, Czech Republic. petr.urbanek@uvn.cz.
FAU - Zavoral, Miroslav
AU  - Zavoral M
AD  - Department of Medicine, 1st Faculty of Medicine, Charles University and Military 
      University Hospital, Prague, Czech Republic. miroslav.zavoral@uvn.cz.
FAU - Suchanek, Stepan
AU  - Suchanek S
AD  - Department of Medicine, 1st Faculty of Medicine, Charles University and Military 
      University Hospital, Prague, Czech Republic. stepan.suchanek@uvn.cz.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20210618
PL  - Romania
TA  - J Gastrointestin Liver Dis
JT  - Journal of gastrointestinal and liver diseases : JGLD
JID - 101272825
RN  - 0 (Cathartics)
RN  - 0 (Detergents)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
SB  - IM
MH  - *Cathartics/adverse effects
MH  - Colonoscopy
MH  - *Detergents
MH  - Humans
MH  - Male
MH  - Polyethylene Glycols/adverse effects
MH  - Prospective Studies
MH  - Single-Blind Method
EDAT- 2021/05/06 06:00
MHDA- 2022/01/15 06:00
CRDT- 2021/05/05 17:48
PHST- 2021/05/06 06:00 [pubmed]
PHST- 2022/01/15 06:00 [medline]
PHST- 2021/05/05 17:48 [entrez]
AID - 10.15403/jgld-3401 [doi]
PST - epublish
SO  - J Gastrointestin Liver Dis. 2021 Jun 18;30(2):213-220. doi: 10.15403/jgld-3401.