PMID- 33951481
OWN - NLM
STAT- MEDLINE
DCOM- 20210706
LR  - 20221207
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 176
DP  - 2021 Jun
TI  - Comparison of islet cell function, insulin sensitivity, and incretin axis between 
      Asian-Indians with either impaired fasting glucose or impaired glucose tolerance, 
      and normal healthy controls.
PG  - 108846
LID - S0168-8227(21)00205-9 [pii]
LID - 10.1016/j.diabres.2021.108846 [doi]
AB  - AIMS: The objective of this study was to compare the islet cell function, insulin 
      sensitivity, and incretin axis between Asian-Indian subjects with either impaired 
      fasting glucose (IFG), or impaired glucose tolerance (IGT), and normal glucose 
      tolerance (NGT). MATERIALS AND METHODS: Prediabetes subjects underwent a mixed 
      meal tolerance test(MMTT) after overnight fasting. Samples for glucose, insulin, 
      glucagon, and glucagon-like peptide-1 (GLP-1) were collected at 0, 30, 60, and 
      120 min. Insulin secretion sensitivity index -2 (ISSI-2) for beta-cell function 
      and Matsuda index for insulin sensitivity were assessed. Alpha cell function was 
      assessed by measuring the area under the curve (AUC) (0-120) glucagon/AUC(0-120) 
      glucose. RESULTS: A total of sixty subjects were recruited with 20 in each group. 
      The beta-cell function represented by ISSI-2 was impaired in prediabetes subjects 
      as compared to NGT group (IFG: 2.09 +/- 0.44 vs. NGT: 3.04 +/- 0.80, P < 0.0001, and 
      IGT: 2.33 +/- 0.59 vs. NGT: 3.04 +/- 0.80, P = 0.002). Similarly, AUC(0-120) 
      glucagon/AUC(0-120) glucose was also lower in prediabetes group as compared to 
      healthy controls (IFG: 0.41(0.54) vs. NGT: 1.07(0.39), P = 0.003 and IGT: 
      0.57(0.38) vs. NGT: 1.07(0.39), P = 0.001). CONCLUSION: Asian-Indian prediabetes 
      subjects have reduced beta-cell function with lesser glucagon secretion during 
      MMTT as compared to normal healthy controls.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Roy, Ayan
AU  - Roy A
AD  - Department of Endocrinology, Jawaharlal Institute of Post Graduate Medical 
      Education and Research (JIPMER), Puducherry, India; Department of Endocrinology 
      and Metabolism, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 
      342005, India.
FAU - Kamalanathan, Sadishkumar
AU  - Kamalanathan S
AD  - Department of Endocrinology, Jawaharlal Institute of Post Graduate Medical 
      Education and Research (JIPMER), Puducherry, India.
FAU - Sahoo, Jayaprakash
AU  - Sahoo J
AD  - Department of Endocrinology, Jawaharlal Institute of Post Graduate Medical 
      Education and Research (JIPMER), Puducherry, India. Electronic address: 
      jppgi@yahoo.com.
FAU - Kar, Sitanshu Sekhar
AU  - Kar SS
AD  - Department of Preventive and Social Medicine, Jawaharlal Institute of Post 
      Graduate Medical Education and Research (JIPMER), Puducherry, India.
FAU - Naik, Dukhabandhu
AU  - Naik D
AD  - Department of Endocrinology, Jawaharlal Institute of Post Graduate Medical 
      Education and Research (JIPMER), Puducherry, India.
FAU - Narayanan, Niya
AU  - Narayanan N
AD  - Department of Endocrinology, Jawaharlal Institute of Post Graduate Medical 
      Education and Research (JIPMER), Puducherry, India.
FAU - Merugu, Chandhana
AU  - Merugu C
AD  - Department of Endocrinology, Jawaharlal Institute of Post Graduate Medical 
      Education and Research (JIPMER), Puducherry, India.
FAU - Patel, Deepika
AU  - Patel D
AD  - Department of Endocrinology, Jawaharlal Institute of Post Graduate Medical 
      Education and Research (JIPMER), Puducherry, India.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20210502
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
RN  - 0 (Incretins)
RN  - 0 (Insulin)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Blood Glucose/metabolism
MH  - Case-Control Studies
MH  - Fasting/blood
MH  - Female
MH  - Glucagon/metabolism
MH  - Glucose Intolerance/ethnology/*metabolism/*physiopathology
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Incretins/*metabolism
MH  - India/ethnology
MH  - Insulin/metabolism
MH  - Insulin Resistance/ethnology/*physiology
MH  - Insulin Secretion/physiology
MH  - Insulin-Secreting Cells/metabolism/*physiology
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/ethnology/metabolism/physiopathology
MH  - Signal Transduction/physiology
OTO - NOTNLM
OT  - Alpha cell
OT  - Beta-cell
OT  - Glucagon
OT  - Glucagon-like peptide-1
OT  - Insulin
OT  - Prediabetes
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/05/06 06:00
MHDA- 2021/07/07 06:00
CRDT- 2021/05/05 20:09
PHST- 2021/03/07 00:00 [received]
PHST- 2021/04/24 00:00 [revised]
PHST- 2021/04/28 00:00 [accepted]
PHST- 2021/05/06 06:00 [pubmed]
PHST- 2021/07/07 06:00 [medline]
PHST- 2021/05/05 20:09 [entrez]
AID - S0168-8227(21)00205-9 [pii]
AID - 10.1016/j.diabres.2021.108846 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2021 Jun;176:108846. doi: 10.1016/j.diabres.2021.108846. 
      Epub 2021 May 2.