PMID- 33952650
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231219
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 96
IP  - 24
DP  - 2021 Jun 14
TI  - Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-analysis.
PG  - e2944-e2955
LID - 10.1212/WNL.0000000000012109 [doi]
AB  - OBJECTIVE: To perform a systematic review and meta-analysis to determine whether 
      fluid and imaging astrocyte biomarkers are altered in Alzheimer disease (AD). 
      METHODS: PubMed and Web of Science databases were searched for articles reporting 
      fluid or imaging astrocyte biomarkers in AD. Pooled effect sizes were determined 
      with standardized mean differences (SMDs) using the Hedge G method with random 
      effects to determine biomarker performance. Adapted questions from the Quality 
      Assessment of Diagnostic Accuracy Studies were applied for quality assessment. A 
      protocol for this study has been previously registered in PROSPERO (registration 
      number: CRD42020192304). RESULTS: The initial search identified 1,425 articles. 
      After exclusion criteria were applied, 33 articles (a total of 3,204 individuals) 
      measuring levels of glial fibrillary acidic protein (GFAP), S100B, 
      chitinase-3-like protein 1 (YKL-40), and aquaporin 4 in the blood and CSF, as 
      well as monoamine oxidase-B indexed by PET (11)C-deuterium-l-deprenyl, were 
      included. GFAP (SMD 0.94, 95% confidence interval [CI] 0.71-1.18) and YKL-40 (SMD 
      0.76, 95% CI 0.63-0.89) levels in the CSF and S100B levels in the blood (SMD 
      2.91, 95% CI 1.01-4.8) were found to be significantly increased in patients with 
      AD. CONCLUSIONS: Despite significant progress, applications of astrocyte 
      biomarkers in AD remain in their early days. This meta-analysis demonstrated that 
      astrocyte biomarkers are consistently altered in AD and supports further 
      investigation for their inclusion in the AD clinical research framework for 
      observational and interventional studies.
CI  - (c) 2021 American Academy of Neurology.
FAU - Bellaver, Bruna
AU  - Bellaver B
AD  - From the Graduate Program in Biological Sciences: Biochemistry (B.B., J.P.F.-S., 
      L.U.d.R., E.R.Z.), Department of Pharmacology (E.R.Z.), and Graduate Program in 
      Biological Sciences: Pharmacology and Therapeutics (E.R.Z.), Universidade Federal 
      do Rio Grande do Sul; Department of Psychiatry (S.F.C.), University of Cambridge; 
      Wolfson Molecular Imaging Centre (S.F.C.), University of Manchester, UK; 
      Department of Neurobiology (E.R.-V, A.N.), Care Sciences and Society, Center for 
      Alzheimer Research, Karolinska Institutet (E.R.-V, A.N.); Theme Aging (A.N.), 
      Karolinska University Hospital Stockholm, Stockholm, Sweden; Inserm U1082 (L.P.), 
      Universite de Poitiers, France; Translational Neuroimaging Laboratory (P.R.-N.), 
      McGill University Research Centre for Studies in Aging, Alzheimer's Disease 
      Research Unit, Douglas Research Institute, Le Centre integre universitaire de 
      sante et de services sociaux (CIUSSS) de l'Ouest-de-l'Ile-de-Montreal; McGill 
      University (P.R.-N.), Montreal, Quebec, Canada; and ADHD Outpatient Program & 
      Development Psychiatry Program (D.T.L.), Hospital de Clinicas de Porto Alegre, 
      Brazil.
FAU - Ferrari-Souza, Joao Pedro
AU  - Ferrari-Souza JP
AUID- ORCID: 0000-0003-2183-1551
AD  - From the Graduate Program in Biological Sciences: Biochemistry (B.B., J.P.F.-S., 
      L.U.d.R., E.R.Z.), Department of Pharmacology (E.R.Z.), and Graduate Program in 
      Biological Sciences: Pharmacology and Therapeutics (E.R.Z.), Universidade Federal 
      do Rio Grande do Sul; Department of Psychiatry (S.F.C.), University of Cambridge; 
      Wolfson Molecular Imaging Centre (S.F.C.), University of Manchester, UK; 
      Department of Neurobiology (E.R.-V, A.N.), Care Sciences and Society, Center for 
      Alzheimer Research, Karolinska Institutet (E.R.-V, A.N.); Theme Aging (A.N.), 
      Karolinska University Hospital Stockholm, Stockholm, Sweden; Inserm U1082 (L.P.), 
      Universite de Poitiers, France; Translational Neuroimaging Laboratory (P.R.-N.), 
      McGill University Research Centre for Studies in Aging, Alzheimer's Disease 
      Research Unit, Douglas Research Institute, Le Centre integre universitaire de 
      sante et de services sociaux (CIUSSS) de l'Ouest-de-l'Ile-de-Montreal; McGill 
      University (P.R.-N.), Montreal, Quebec, Canada; and ADHD Outpatient Program & 
      Development Psychiatry Program (D.T.L.), Hospital de Clinicas de Porto Alegre, 
      Brazil.
FAU - Uglione da Ros, Lucas
AU  - Uglione da Ros L
AD  - From the Graduate Program in Biological Sciences: Biochemistry (B.B., J.P.F.-S., 
      L.U.d.R., E.R.Z.), Department of Pharmacology (E.R.Z.), and Graduate Program in 
      Biological Sciences: Pharmacology and Therapeutics (E.R.Z.), Universidade Federal 
      do Rio Grande do Sul; Department of Psychiatry (S.F.C.), University of Cambridge; 
      Wolfson Molecular Imaging Centre (S.F.C.), University of Manchester, UK; 
      Department of Neurobiology (E.R.-V, A.N.), Care Sciences and Society, Center for 
      Alzheimer Research, Karolinska Institutet (E.R.-V, A.N.); Theme Aging (A.N.), 
      Karolinska University Hospital Stockholm, Stockholm, Sweden; Inserm U1082 (L.P.), 
      Universite de Poitiers, France; Translational Neuroimaging Laboratory (P.R.-N.), 
      McGill University Research Centre for Studies in Aging, Alzheimer's Disease 
      Research Unit, Douglas Research Institute, Le Centre integre universitaire de 
      sante et de services sociaux (CIUSSS) de l'Ouest-de-l'Ile-de-Montreal; McGill 
      University (P.R.-N.), Montreal, Quebec, Canada; and ADHD Outpatient Program & 
      Development Psychiatry Program (D.T.L.), Hospital de Clinicas de Porto Alegre, 
      Brazil.
FAU - Carter, Stephen F
AU  - Carter SF
AUID- ORCID: 0000-0002-9080-519X
AD  - From the Graduate Program in Biological Sciences: Biochemistry (B.B., J.P.F.-S., 
      L.U.d.R., E.R.Z.), Department of Pharmacology (E.R.Z.), and Graduate Program in 
      Biological Sciences: Pharmacology and Therapeutics (E.R.Z.), Universidade Federal 
      do Rio Grande do Sul; Department of Psychiatry (S.F.C.), University of Cambridge; 
      Wolfson Molecular Imaging Centre (S.F.C.), University of Manchester, UK; 
      Department of Neurobiology (E.R.-V, A.N.), Care Sciences and Society, Center for 
      Alzheimer Research, Karolinska Institutet (E.R.-V, A.N.); Theme Aging (A.N.), 
      Karolinska University Hospital Stockholm, Stockholm, Sweden; Inserm U1082 (L.P.), 
      Universite de Poitiers, France; Translational Neuroimaging Laboratory (P.R.-N.), 
      McGill University Research Centre for Studies in Aging, Alzheimer's Disease 
      Research Unit, Douglas Research Institute, Le Centre integre universitaire de 
      sante et de services sociaux (CIUSSS) de l'Ouest-de-l'Ile-de-Montreal; McGill 
      University (P.R.-N.), Montreal, Quebec, Canada; and ADHD Outpatient Program & 
      Development Psychiatry Program (D.T.L.), Hospital de Clinicas de Porto Alegre, 
      Brazil.
FAU - Rodriguez-Vieitez, Elena
AU  - Rodriguez-Vieitez E
AUID- ORCID: 0000-0002-6639-8141
AD  - From the Graduate Program in Biological Sciences: Biochemistry (B.B., J.P.F.-S., 
      L.U.d.R., E.R.Z.), Department of Pharmacology (E.R.Z.), and Graduate Program in 
      Biological Sciences: Pharmacology and Therapeutics (E.R.Z.), Universidade Federal 
      do Rio Grande do Sul; Department of Psychiatry (S.F.C.), University of Cambridge; 
      Wolfson Molecular Imaging Centre (S.F.C.), University of Manchester, UK; 
      Department of Neurobiology (E.R.-V, A.N.), Care Sciences and Society, Center for 
      Alzheimer Research, Karolinska Institutet (E.R.-V, A.N.); Theme Aging (A.N.), 
      Karolinska University Hospital Stockholm, Stockholm, Sweden; Inserm U1082 (L.P.), 
      Universite de Poitiers, France; Translational Neuroimaging Laboratory (P.R.-N.), 
      McGill University Research Centre for Studies in Aging, Alzheimer's Disease 
      Research Unit, Douglas Research Institute, Le Centre integre universitaire de 
      sante et de services sociaux (CIUSSS) de l'Ouest-de-l'Ile-de-Montreal; McGill 
      University (P.R.-N.), Montreal, Quebec, Canada; and ADHD Outpatient Program & 
      Development Psychiatry Program (D.T.L.), Hospital de Clinicas de Porto Alegre, 
      Brazil.
FAU - Nordberg, Agneta
AU  - Nordberg A
AUID- ORCID: 0000-0001-7345-5151
AD  - From the Graduate Program in Biological Sciences: Biochemistry (B.B., J.P.F.-S., 
      L.U.d.R., E.R.Z.), Department of Pharmacology (E.R.Z.), and Graduate Program in 
      Biological Sciences: Pharmacology and Therapeutics (E.R.Z.), Universidade Federal 
      do Rio Grande do Sul; Department of Psychiatry (S.F.C.), University of Cambridge; 
      Wolfson Molecular Imaging Centre (S.F.C.), University of Manchester, UK; 
      Department of Neurobiology (E.R.-V, A.N.), Care Sciences and Society, Center for 
      Alzheimer Research, Karolinska Institutet (E.R.-V, A.N.); Theme Aging (A.N.), 
      Karolinska University Hospital Stockholm, Stockholm, Sweden; Inserm U1082 (L.P.), 
      Universite de Poitiers, France; Translational Neuroimaging Laboratory (P.R.-N.), 
      McGill University Research Centre for Studies in Aging, Alzheimer's Disease 
      Research Unit, Douglas Research Institute, Le Centre integre universitaire de 
      sante et de services sociaux (CIUSSS) de l'Ouest-de-l'Ile-de-Montreal; McGill 
      University (P.R.-N.), Montreal, Quebec, Canada; and ADHD Outpatient Program & 
      Development Psychiatry Program (D.T.L.), Hospital de Clinicas de Porto Alegre, 
      Brazil.
FAU - Pellerin, Luc
AU  - Pellerin L
AUID- ORCID: 0000-0002-1016-1970
AD  - From the Graduate Program in Biological Sciences: Biochemistry (B.B., J.P.F.-S., 
      L.U.d.R., E.R.Z.), Department of Pharmacology (E.R.Z.), and Graduate Program in 
      Biological Sciences: Pharmacology and Therapeutics (E.R.Z.), Universidade Federal 
      do Rio Grande do Sul; Department of Psychiatry (S.F.C.), University of Cambridge; 
      Wolfson Molecular Imaging Centre (S.F.C.), University of Manchester, UK; 
      Department of Neurobiology (E.R.-V, A.N.), Care Sciences and Society, Center for 
      Alzheimer Research, Karolinska Institutet (E.R.-V, A.N.); Theme Aging (A.N.), 
      Karolinska University Hospital Stockholm, Stockholm, Sweden; Inserm U1082 (L.P.), 
      Universite de Poitiers, France; Translational Neuroimaging Laboratory (P.R.-N.), 
      McGill University Research Centre for Studies in Aging, Alzheimer's Disease 
      Research Unit, Douglas Research Institute, Le Centre integre universitaire de 
      sante et de services sociaux (CIUSSS) de l'Ouest-de-l'Ile-de-Montreal; McGill 
      University (P.R.-N.), Montreal, Quebec, Canada; and ADHD Outpatient Program & 
      Development Psychiatry Program (D.T.L.), Hospital de Clinicas de Porto Alegre, 
      Brazil.
FAU - Rosa-Neto, Pedro
AU  - Rosa-Neto P
AUID- ORCID: 0000-0001-9116-1376
AD  - From the Graduate Program in Biological Sciences: Biochemistry (B.B., J.P.F.-S., 
      L.U.d.R., E.R.Z.), Department of Pharmacology (E.R.Z.), and Graduate Program in 
      Biological Sciences: Pharmacology and Therapeutics (E.R.Z.), Universidade Federal 
      do Rio Grande do Sul; Department of Psychiatry (S.F.C.), University of Cambridge; 
      Wolfson Molecular Imaging Centre (S.F.C.), University of Manchester, UK; 
      Department of Neurobiology (E.R.-V, A.N.), Care Sciences and Society, Center for 
      Alzheimer Research, Karolinska Institutet (E.R.-V, A.N.); Theme Aging (A.N.), 
      Karolinska University Hospital Stockholm, Stockholm, Sweden; Inserm U1082 (L.P.), 
      Universite de Poitiers, France; Translational Neuroimaging Laboratory (P.R.-N.), 
      McGill University Research Centre for Studies in Aging, Alzheimer's Disease 
      Research Unit, Douglas Research Institute, Le Centre integre universitaire de 
      sante et de services sociaux (CIUSSS) de l'Ouest-de-l'Ile-de-Montreal; McGill 
      University (P.R.-N.), Montreal, Quebec, Canada; and ADHD Outpatient Program & 
      Development Psychiatry Program (D.T.L.), Hospital de Clinicas de Porto Alegre, 
      Brazil.
FAU - Leffa, Douglas Teixeira
AU  - Leffa DT
AUID- ORCID: 0000-0002-4890-8451
AD  - From the Graduate Program in Biological Sciences: Biochemistry (B.B., J.P.F.-S., 
      L.U.d.R., E.R.Z.), Department of Pharmacology (E.R.Z.), and Graduate Program in 
      Biological Sciences: Pharmacology and Therapeutics (E.R.Z.), Universidade Federal 
      do Rio Grande do Sul; Department of Psychiatry (S.F.C.), University of Cambridge; 
      Wolfson Molecular Imaging Centre (S.F.C.), University of Manchester, UK; 
      Department of Neurobiology (E.R.-V, A.N.), Care Sciences and Society, Center for 
      Alzheimer Research, Karolinska Institutet (E.R.-V, A.N.); Theme Aging (A.N.), 
      Karolinska University Hospital Stockholm, Stockholm, Sweden; Inserm U1082 (L.P.), 
      Universite de Poitiers, France; Translational Neuroimaging Laboratory (P.R.-N.), 
      McGill University Research Centre for Studies in Aging, Alzheimer's Disease 
      Research Unit, Douglas Research Institute, Le Centre integre universitaire de 
      sante et de services sociaux (CIUSSS) de l'Ouest-de-l'Ile-de-Montreal; McGill 
      University (P.R.-N.), Montreal, Quebec, Canada; and ADHD Outpatient Program & 
      Development Psychiatry Program (D.T.L.), Hospital de Clinicas de Porto Alegre, 
      Brazil.
FAU - Zimmer, Eduardo R
AU  - Zimmer ER
AD  - From the Graduate Program in Biological Sciences: Biochemistry (B.B., J.P.F.-S., 
      L.U.d.R., E.R.Z.), Department of Pharmacology (E.R.Z.), and Graduate Program in 
      Biological Sciences: Pharmacology and Therapeutics (E.R.Z.), Universidade Federal 
      do Rio Grande do Sul; Department of Psychiatry (S.F.C.), University of Cambridge; 
      Wolfson Molecular Imaging Centre (S.F.C.), University of Manchester, UK; 
      Department of Neurobiology (E.R.-V, A.N.), Care Sciences and Society, Center for 
      Alzheimer Research, Karolinska Institutet (E.R.-V, A.N.); Theme Aging (A.N.), 
      Karolinska University Hospital Stockholm, Stockholm, Sweden; Inserm U1082 (L.P.), 
      Universite de Poitiers, France; Translational Neuroimaging Laboratory (P.R.-N.), 
      McGill University Research Centre for Studies in Aging, Alzheimer's Disease 
      Research Unit, Douglas Research Institute, Le Centre integre universitaire de 
      sante et de services sociaux (CIUSSS) de l'Ouest-de-l'Ile-de-Montreal; McGill 
      University (P.R.-N.), Montreal, Quebec, Canada; and ADHD Outpatient Program & 
      Development Psychiatry Program (D.T.L.), Hospital de Clinicas de Porto Alegre, 
      Brazil. eduardo.zimmer@ufrgs.br.
LA  - eng
PT  - Journal Article
DEP - 20210614
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
EDAT- 2021/05/07 06:00
MHDA- 2021/05/07 06:01
CRDT- 2021/05/06 05:56
PHST- 2020/12/02 00:00 [received]
PHST- 2021/03/19 00:00 [accepted]
PHST- 2021/05/07 06:01 [medline]
PHST- 2021/05/07 06:00 [pubmed]
PHST- 2021/05/06 05:56 [entrez]
AID - WNL.0000000000012109 [pii]
AID - 10.1212/WNL.0000000000012109 [doi]
PST - epublish
SO  - Neurology. 2021 Jun 14;96(24):e2944-e2955. doi: 10.1212/WNL.0000000000012109.