PMID- 33952652
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231227
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 96
IP  - 24
DP  - 2021 Jun 15
TI  - Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age.
PG  - e2920-e2932
LID - 10.1212/WNL.0000000000012067 [doi]
AB  - OBJECTIVE: To determine whether following a Mediterranean-like diet (MeDi) 
      relates to cognitive functions and in vivo biomarkers for Alzheimer disease (AD), 
      we analyzed cross-sectional data from the German DZNE-Longitudinal Cognitive 
      Impairment and Dementia Study. METHOD: The sample (n=512, mean age: 69.5+/-5.9 
      years) included 169 cognitively normal participants and subjects at higher AD 
      risk (53 with relatives with AD, 209 with subjective cognitive decline, and 81 
      with mild cognitive impairment). We defined MeDi adherence based on the Food 
      Frequency Questionnaire. Brain volume outcomes were generated via voxel-based 
      morphometry on T1-MRI and cognitive performance with an extensive 
      neuropsychological battery. AD-related biomarkers (Abeta42/40 ratio, pTau181) in 
      cerebrospinal fluid were assessed in n=226 individuals. We analyzed the 
      associations between MeDi and the outcomes with linear regression models 
      controlling for several covariates. Additionally, we applied hypothesis-driven 
      mediation and moderation analysis. RESULTS: Higher MeDi adherence related to 
      larger mediotemporal gray matter volume (p<0.05 FWE corrected), better memory 
      (beta+/-SE = 0.03 +/- 0.02; p=0.038), and less amyloid (Abeta42/40 ratio, beta+/-SE = 0.003 +/- 
      0.001; p=0.008) and pTau181 pathology (beta+/-SE = -1.96+/-0.68; p=0.004). Mediotemporal 
      volume mediated the association between MeDi and memory (40% indirect mediation). 
      Finally, MeDi favorably moderated the associations between Abeta42/40 ratio, pTau181 
      and mediotemporal atrophy. Results were consistent correcting for ApoE-epsilon4 status. 
      CONCLUSION: Our findings corroborate the view of MeDi as a protective factor 
      against memory decline and mediotemporal atrophy. Importantly, they suggest that 
      these associations might be explained by a decrease of amyloidosis and 
      tau-pathology. Longitudinal and dietary intervention studies should further 
      examine this conjecture and its treatment implications.
CI  - (c) 2021 American Academy of Neurology.
FAU - Ballarini, Tommaso
AU  - Ballarini T
AUID- ORCID: 0000-0001-7299-5973
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany tommaso.ballarini@dzne.de.
FAU - Melo van Lent, Debora
AU  - Melo van Lent D
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
AD  - University of Texas Health Science Center at San Antonio: San Antonio, TX, US.
FAU - Brunner, Julia
AU  - Brunner J
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
FAU - Schroder, Alina
AU  - Schroder A
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
FAU - Wolfsgruber, Steffen
AU  - Wolfsgruber S
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
AD  - Department of Neurodegeneration and Geriatric Psychiatry, University Hospital 
      Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
FAU - Altenstein, Slawek
AU  - Altenstein S
AD  - German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
AD  - Department of Psychiatry and Psychotherapy, Charite, Chariteplatz 1, 10117 
      Berlin, Germany.
FAU - Brosseron, Frederic
AU  - Brosseron F
AUID- ORCID: 0000-0003-3137-7516
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
AD  - Department of Neurodegeneration and Geriatric Psychiatry, University Hospital 
      Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
FAU - Buerger, Katharina
AU  - Buerger K
AD  - German Center for Neurodegenerative Diseases (DZNE, Munich), Feodor-Lynen-Strasse 
      17, 81377 Munich, Germany.
AD  - Institute for Stroke and Dementia Research (ISD), University Hospital, LMU 
      Munich, Feodor-LynenStrasse 17, 81377 Munich, Germany.
FAU - Dechent, Peter
AU  - Dechent P
AD  - MR-Research in Neurology and Psychiatry, Georg-AugustUniversity Gottingen, 
      Germany.
FAU - Dobisch, Laura
AU  - Dobisch L
AD  - German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
AD  - Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke 
      University, Magdeburg, Germany.
FAU - Duzel, Emrah
AU  - Duzel E
AD  - German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
AD  - Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke 
      University, Magdeburg, Germany.
FAU - Ertl-Wagner, Birgit
AU  - Ertl-Wagner B
AD  - Institute for Clinical Radiology, Ludwig-MaximiliansUniversity, Marchioninistr. 
      15, 81377 Munich.
FAU - Fliessbach, Klaus
AU  - Fliessbach K
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
AD  - Department of Neurodegeneration and Geriatric Psychiatry, University Hospital 
      Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
FAU - Freiesleben, Silka Dawn
AU  - Freiesleben SD
AD  - Charite Universitatsmedizin Berlin, Department of Psychiatry and Psychotherapy, 
      Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.
FAU - Frommann, Ingo
AU  - Frommann I
AUID- ORCID: 0000-0002-7244-2014
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
FAU - Glanz, Wenzel
AU  - Glanz W
AD  - German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
FAU - Hauser, Dietmar
AU  - Hauser D
AD  - Charite Universitatsmedizin Berlin, Department of Psychiatry and Psychotherapy, 
      Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.
FAU - Haynes, John Dylan
AU  - Haynes JD
AD  - Bernstein Center for Computational Neuroscience, Charite Universitatsmedizin, 
      Berlin, Germany.
FAU - Heneka, Michael T
AU  - Heneka MT
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
AD  - Department of Neurodegeneration and Geriatric Psychiatry, University Hospital 
      Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
FAU - Janowitz, Daniel
AU  - Janowitz D
AD  - Institute for Stroke and Dementia Research (ISD), University Hospital, LMU 
      Munich, Feodor-Lynen-Strasse 17, 81377 Munich, Germany.
FAU - Kilimann, Ingo
AU  - Kilimann I
AD  - German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
AD  - Department of Psychosomatic Medicine, Rostock University Medical Center, 
      Gehlsheimer Str. 20, 18147 Rostock.
FAU - Laske, Christoph
AU  - Laske C
AD  - German Center for Neurodegenerative Diseases (DZNE), Tubingen, Germany.
AD  - Section for Dementia Research, Hertie Institute for Clinical Brain Research and 
      Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, 
      Germany.
FAU - Maier, Franziska
AU  - Maier F
AD  - Department of Psychiatry, University of Cologne, Medical Faculty, Kerpener 
      Strasse 62, 50924 Cologne, Germany.
FAU - Metzger, Coraline Danielle
AU  - Metzger CD
AD  - German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
AD  - Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke 
      University, Magdeburg, Germany.
FAU - Munk, Matthias
AU  - Munk M
AD  - German Center for Neurodegenerative Diseases (DZNE), Tubingen, Germany.
AD  - Section for Dementia Research, Hertie Institute for Clinical Brain Research and 
      Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, 
      Germany.
FAU - Perneczky, Robert
AU  - Perneczky R
AUID- ORCID: 0000-0003-1981-7435
AD  - German Center for Neurodegenerative Diseases (DZNE, Munich), Feodor-Lynen-Strasse 
      17, 81377 Munich, Germany.
AD  - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 
      Munich, Germany.
AD  - Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.
AD  - Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial 
      College London, London, UK.
FAU - Peters, Oliver
AU  - Peters O
AD  - German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
AD  - Charite Universitatsmedizin Berlin, Department of Psychiatry and Psychotherapy, 
      Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.
FAU - Priller, Josef
AU  - Priller J
AD  - German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
AD  - Department of Psychiatry and Psychotherapy, Charite, Chariteplatz 1, 10117 
      Berlin, Germany.
FAU - Ramirez, Alfredo
AU  - Ramirez A
AUID- ORCID: 0000-0003-4991-763X
AD  - Department of Psychiatry, University of Cologne, Medical Faculty, Kerpener 
      Strasse 62, 50924 Cologne, Germany.
FAU - Rauchmann, Boris
AU  - Rauchmann B
AD  - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 
      Munich, Germany.
FAU - Roy, Nina
AU  - Roy N
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
FAU - Scheffler, Klaus
AU  - Scheffler K
AUID- ORCID: 0000-0001-6316-8773
AD  - Department for Biomedical Magnetic Resonance, University of Tubingen, 72076 
      Tubingen, Germany.
FAU - Schneider, Anja
AU  - Schneider A
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
AD  - Department of Neurodegeneration and Geriatric Psychiatry, University Hospital 
      Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
FAU - Spottke, Annika
AU  - Spottke A
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
AD  - Department of Neurology, University of Bonn, Venusberg-Campus 1, 53127 Bonn, 
      Germany.
FAU - Spruth, Eike Jakob
AU  - Spruth EJ
AD  - German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
AD  - Department of Psychiatry and Psychotherapy, Charite, Chariteplatz 1, 10117 
      Berlin, Germany.
FAU - Teipel, Stefan J
AU  - Teipel SJ
AD  - German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
AD  - Department of Psychosomatic Medicine, Rostock University Medical Center, 
      Gehlsheimer Str. 20, 18147 Rostock.
FAU - Vukovich, Ruth
AU  - Vukovich R
AD  - Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, 
      University of Goettingen, Von-Siebold-Str. 5, 37075 Goettingen.
FAU - Wiltfang, Jens
AU  - Wiltfang J
AD  - Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, 
      University of Goettingen, Von-Siebold-Str. 5, 37075 Goettingen.
AD  - German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.
AD  - Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED).
AD  - Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
FAU - Jessen, Frank
AU  - Jessen F
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
AD  - Department of Psychiatry, University of Cologne, Medical Faculty, Kerpener 
      Strasse 62, 50924 Cologne, Germany.
AD  - Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases 
      (CECAD), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931Koln, Germany.
FAU - Wagner, Michael
AU  - Wagner M
AUID- ORCID: 0000-0003-2589-6440
AD  - German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, 
      53127 Bonn, Germany.
AD  - Department of Neurodegeneration and Geriatric Psychiatry, University Hospital 
      Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
CN  - DELCODE study group
LA  - eng
PT  - Journal Article
DEP - 20210615
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
CIN - Neurology. 2022 Jan 11;98(2):88-89. PMID: 35263268
CIN - Neurology. 2022 Jan 11;98(2):89-90. PMID: 35263270
PMC - PMC8253566
EDAT- 2021/05/07 06:00
MHDA- 2021/05/07 06:01
PMCR- 2021/06/15
CRDT- 2021/05/06 05:56
PHST- 2021/05/05 00:00 [aheadofprint]
PHST- 2020/08/06 00:00 [received]
PHST- 2021/03/15 00:00 [accepted]
PHST- 2021/05/07 06:01 [medline]
PHST- 2021/05/06 05:56 [entrez]
PHST- 2021/05/07 06:00 [pubmed]
PHST- 2021/06/15 00:00 [pmc-release]
AID - WNL.0000000000012067 [pii]
AID - NEUROLOGY2020128397 [pii]
AID - 10.1212/WNL.0000000000012067 [doi]
PST - epublish
SO  - Neurology. 2021 Jun 15;96(24):e2920-e2932. doi: 10.1212/WNL.0000000000012067.