PMID- 33953227
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20211022
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 May 5
TI  - Determinants of peripapillary retinal nerve fiber layer's grayscale value in 
      normal eyes by spectral domain optical coherence tomography.
PG  - 9577
LID - 10.1038/s41598-021-88604-x [doi]
LID - 9577
AB  - To determine and evaluate the distribution, variation, and determinants of 
      peripapillary retinal nerve fiber layer (pRNFL) grayscale value with 
      spectral-domain optical coherence tomography (SD-OCT) in normal eyes. In this 
      cross-sectional study, three hundred ninety-seven normal eyes from 397 healthy 
      Chinese adults aged 18-80 were consecutively recruited from a tertiary eye care 
      center. An SD-OCT instrument took pRNFL imaging. We used a customized software to 
      measure pRNFL parameters, including thickness and grayscale value. Univariable 
      and multiple linear regression analyses were performed to examine the 
      relationship between pRNFL grayscale value with ocular (e.g., axial length 
      [A.L.], spherical equivalent [S.E.], intraocular pressure [IOP]), and systemic 
      (e.g., age, sex) factors. A total of 397 eyes from 397 healthy subjects were 
      included in the final analysis with mean (+/- SD) age 44.63 +/- 16.43 years (range 
      18-80 years) and 196 (49.4%) males. The mean average of pRNFL grayscale value and 
      thickness 164.82 +/- 5.69 and 106.68 +/- 8.89 mum, respectively. pRNFL grayscale value 
      in nasal sectors (163.26 +/- 9.31) was significantly lower comparing those in all 
      other five sectors (all with p < 0.001)]. In multivariable analysis, average 
      pRNFL grayscale value was independently correlated to older age (beta = - 0.053, 
      p = 0.002), longer axial length (beta = - 0.664, p = 0.003), lower RPE grayscale 
      value (beta = 0.372, p < 0.001) and lower ImageQ (beta = 0.658, p < 0.001). In this 
      study, we provided normative SD-OCT data on the pRNFL grayscale value profile in 
      nonglaucomatous eyes. Lower average pRNFL grayscale value was independently 
      correlated to older age, longer axial length, lower RPE grayscale value, and 
      lower ImageQ. These determinants should be considered when interpreting pRNFL 
      grayscale value in glaucoma assessment.
FAU - Xie, Xiaolin
AU  - Xie X
AD  - Joint Shantou International Eye Center of Shantou University and the Chinese 
      University of Hong Kong, Shantou University Medical College, Shantou, 515000, 
      Guangdong, China.
FAU - Chen, Binyao
AU  - Chen B
AD  - Joint Shantou International Eye Center of Shantou University and the Chinese 
      University of Hong Kong, Shantou University Medical College, Shantou, 515000, 
      Guangdong, China.
FAU - Yang, Jianling
AU  - Yang J
AD  - Joint Shantou International Eye Center of Shantou University and the Chinese 
      University of Hong Kong, Shantou University Medical College, Shantou, 515000, 
      Guangdong, China.
FAU - Huang, Chukai
AU  - Huang C
AD  - Joint Shantou International Eye Center of Shantou University and the Chinese 
      University of Hong Kong, Shantou University Medical College, Shantou, 515000, 
      Guangdong, China.
FAU - Qiu, Kunliang
AU  - Qiu K
AD  - Joint Shantou International Eye Center of Shantou University and the Chinese 
      University of Hong Kong, Shantou University Medical College, Shantou, 515000, 
      Guangdong, China.
FAU - Zheng, Ce
AU  - Zheng C
AD  - Department of Ophthalmology, Xinhua Hospital, Affiliated to Shanghai Jiaotong 
      University School of Medicine, Shanghai, China. zhengce@xinhuamed.com.cn.
FAU - Zhang, Mingzhi
AU  - Zhang M
AD  - Joint Shantou International Eye Center of Shantou University and the Chinese 
      University of Hong Kong, Shantou University Medical College, Shantou, 515000, 
      Guangdong, China. zmz0754@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210505
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retina/cytology/*diagnostic imaging
MH  - Retinal Neurons/*cytology
MH  - Tomography, Optical Coherence
MH  - Young Adult
PMC - PMC8100177
COIS- The authors declare no competing interests.
EDAT- 2021/05/07 06:00
MHDA- 2023/02/25 06:00
PMCR- 2021/05/05
CRDT- 2021/05/06 06:35
PHST- 2020/11/03 00:00 [received]
PHST- 2021/04/05 00:00 [accepted]
PHST- 2021/05/06 06:35 [entrez]
PHST- 2021/05/07 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2021/05/05 00:00 [pmc-release]
AID - 10.1038/s41598-021-88604-x [pii]
AID - 88604 [pii]
AID - 10.1038/s41598-021-88604-x [doi]
PST - epublish
SO  - Sci Rep. 2021 May 5;11(1):9577. doi: 10.1038/s41598-021-88604-x.