PMID- 33953977
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 2090-0724 (Print)
IS  - 2090-0732 (Electronic)
IS  - 2090-0724 (Linking)
VI  - 2021
DP  - 2021
TI  - Effect of a High-Protein High-Fibre Nutritional Supplement on Lipid Profile in 
      Overweight/Obese Adults with Type 2 Diabetes Mellitus: A 24-Week Randomized 
      Controlled Trial.
PG  - 6634225
LID - 10.1155/2021/6634225 [doi]
LID - 6634225
AB  - BACKGROUND: Foods rich in protein and dietary fibre could potentially improve 
      lipid profile in overweight or obese diabetic patients with dyslipidemia and, 
      thereby, mitigate their risk of cardiovascular disease (CVD). In this study, the 
      effect of providing high-protein high-fibre (HPHF) nutritional supplement in 
      addition to standard care of type 2 diabetes mellitus (T2DM) on lipid profile was 
      evaluated. METHODS: In this open-label, parallel-arm, prospective, randomized 
      study, a total of 100 overweight/obese participants with T2DM were randomized to 
      either an intervention group (25 g HPHF nutritional supplement given twice daily 
      along with a standard care of T2DM) or a control group (standard care of T2DM) 
      for 24 weeks. Change from baseline in lipid parameters such as total cholesterol 
      (TChol), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein 
      cholesterol (LDL-C), and triglycerides (TG) was assessed between the intervention 
      and control group at week 12 and week 24. Participant compliance was assessed 
      using the dietary 24-hour recall. Statistical analysis was performed to assess 
      the main effects on within- and between-group changes from baseline to end of 24 
      weeks. RESULTS: Participants in the HPHF nutritional supplement group showed a 
      statistically significant improvement in HDL-C levels by the end of 24 weeks 
      (p=0.04) and a significant increase in protein and total dietary fibre intake 
      (p=0.002 and p=0.00, respectively) compared to the control group. The TChol/HDL-C 
      ratio was significantly lower (p=0.03) in the HPHF group from baseline to 24 
      weeks. CONCLUSION: Twice-daily consumption of a HPHF nutritional supplement 
      significantly improved HDL-C levels. Inclusion of the HPHF supplement would be a 
      useful effective aid for managing dyslipidemia in overweight/obese individuals 
      with T2DM.
CI  - Copyright (c) 2021 Rachana Bhoite et al.
FAU - Bhoite, Rachana
AU  - Bhoite R
AUID- ORCID: 0000-0001-5291-6799
AD  - Dr. Reddy's Laboratories Pvt Ltd., Ameerpet, Hyderabad, India.
FAU - Chandrasekaran, Anitha
AU  - Chandrasekaran A
AD  - Department of Diabetology, Dr. Mohan's Diabetes Specialities Centre, Chennai, 
      India.
FAU - Pratti, Varalakshmi Lalithya
AU  - Pratti VL
AD  - Dr. Reddy's Laboratories Pvt Ltd., Ameerpet, Hyderabad, India.
FAU - Satyavrat, Vinita
AU  - Satyavrat V
AD  - Dr. Reddy's Laboratories Pvt Ltd., Ameerpet, Hyderabad, India.
FAU - Aacharya, Shivani
AU  - Aacharya S
AD  - Dr. Reddy's Laboratories Pvt Ltd., Ameerpet, Hyderabad, India.
FAU - Mane, Amey
AU  - Mane A
AD  - Dr. Reddy's Laboratories Pvt Ltd., Ameerpet, Hyderabad, India.
FAU - Mehta, Suyog
AU  - Mehta S
AD  - Dr. Reddy's Laboratories Pvt Ltd., Ameerpet, Hyderabad, India.
FAU - Kale, Ravindra Machhindra
AU  - Kale RM
AD  - Dr. Reddy's Laboratories Pvt Ltd., Ameerpet, Hyderabad, India.
FAU - Nagamuthu, Gayathri
AU  - Nagamuthu G
AD  - Department of Foods, Nutrition & Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, India.
FAU - Selvaraj, Sasikala
AU  - Selvaraj S
AD  - Department of Foods, Nutrition & Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, India.
FAU - Rajagopal, Gayathri
AU  - Rajagopal G
AD  - Department of Foods, Nutrition & Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, India.
FAU - Vasudevan, Sudha
AU  - Vasudevan S
AD  - Department of Foods, Nutrition & Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, India.
FAU - Shanmugam, Shobana
AU  - Shanmugam S
AD  - Department of Foods, Nutrition & Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, India.
FAU - Mohan, Anjana Ranjit
AU  - Mohan AR
AD  - Department of Diabetology, Dr. Mohan's Diabetes Specialities Centre, Chennai, 
      India.
AD  - Department of Foods, Nutrition & Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, India.
FAU - Unnikrishnan, Ranjit
AU  - Unnikrishnan R
AD  - Department of Diabetology, Dr. Mohan's Diabetes Specialities Centre, Chennai, 
      India.
AD  - Department of Foods, Nutrition & Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, India.
FAU - Krishnaswamy, Kamala
AU  - Krishnaswamy K
AD  - Department of Foods, Nutrition & Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, India.
FAU - Mohan, Viswanathan
AU  - Mohan V
AD  - Department of Diabetology, Dr. Mohan's Diabetes Specialities Centre, Chennai, 
      India.
AD  - Department of Foods, Nutrition & Dietetics Research, Madras Diabetes Research 
      Foundation, Chennai, India.
LA  - eng
PT  - Journal Article
DEP - 20210415
PL  - United States
TA  - J Nutr Metab
JT  - Journal of nutrition and metabolism
JID - 101526296
PMC - PMC8064784
COIS- The authors report no conflicts of interest.
EDAT- 2021/05/07 06:00
MHDA- 2021/05/07 06:01
PMCR- 2021/04/15
CRDT- 2021/05/06 07:05
PHST- 2020/11/27 00:00 [received]
PHST- 2021/02/19 00:00 [revised]
PHST- 2021/04/01 00:00 [accepted]
PHST- 2021/05/06 07:05 [entrez]
PHST- 2021/05/07 06:00 [pubmed]
PHST- 2021/05/07 06:01 [medline]
PHST- 2021/04/15 00:00 [pmc-release]
AID - 10.1155/2021/6634225 [doi]
PST - epublish
SO  - J Nutr Metab. 2021 Apr 15;2021:6634225. doi: 10.1155/2021/6634225. eCollection 
      2021.