PMID- 3395448
OWN - NLM
STAT- MEDLINE
DCOM- 19880902
LR  - 20190908
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 102
IP  - 3
DP  - 1988 Jun
TI  - Axon-sparing lesions of the preoptic region and substantia innominata disrupt 
      maternal behavior in rats.
PG  - 381-96
AB  - In this study we investigated the effects of axon-sparing lesions of the preoptic 
      region on the maternal behavior of postpartum rats. The lesions were produced 
      with the excitotoxic amino acid N-methyl-D,L-aspartic acid (NMA). The first 
      experiment determined that bilateral injections of NMA into the medial preoptic 
      area (MPOA) of fully maternal lactating rats disrupted maternal behavior. In a 
      second experiment, bilateral injections of NMA into the lateral preoptic area and 
      adjoining substantia innominata (LP/SI region) also disrupted maternal behavior. 
      A third experiment, employing horseradish peroxidase histochemistry, provided 
      anatomical evidence that NMA destroys neuronal cell bodies while sparing fibers 
      of passage. These findings were discussed with respect to the view that an 
      MPOA-to-LP/SI-to-ventral tegmental area circuit underlies maternal behavior in 
      the rat.
FAU - Numan, M
AU  - Numan M
AD  - Department of Psychology, Boston College, Chestnut Hill, Massachusetts 02167.
FAU - Corodimas, K P
AU  - Corodimas KP
FAU - Numan, M J
AU  - Numan MJ
FAU - Factor, E M
AU  - Factor EM
FAU - Piers, W D
AU  - Piers WD
LA  - eng
GR  - HD 18904/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
SB  - IM
MH  - Animals
MH  - Axons/*physiology
MH  - Basal Ganglia/*physiology
MH  - Brain Mapping
MH  - Female
MH  - *Maternal Behavior
MH  - Nerve Fibers/physiology
MH  - Nesting Behavior/physiology
MH  - Neural Pathways/physiology
MH  - Neurons/physiology
MH  - Preoptic Area/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Substantia Innominata/*physiology
MH  - Tegmentum Mesencephali/physiology
EDAT- 1988/06/01 00:00
MHDA- 1988/06/01 00:01
CRDT- 1988/06/01 00:00
PHST- 1988/06/01 00:00 [pubmed]
PHST- 1988/06/01 00:01 [medline]
PHST- 1988/06/01 00:00 [entrez]
AID - 10.1037//0735-7044.102.3.381 [doi]
PST - ppublish
SO  - Behav Neurosci. 1988 Jun;102(3):381-96. doi: 10.1037//0735-7044.102.3.381.