PMID- 33957555
OWN - NLM
STAT- MEDLINE
DCOM- 20211223
LR  - 20211223
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 104
DP  - 2021 Aug
TI  - Default mode network connectivity and cognition in the aging brain: the effects 
      of age, sex, and APOE genotype.
PG  - 10-23
LID - S0197-4580(21)00111-1 [pii]
LID - 10.1016/j.neurobiolaging.2021.03.013 [doi]
AB  - The default mode network (DMN) overlaps with regions showing early Alzheimer's 
      Disease (AD) pathology. Age, sex, and apolipoprotein E varepsilon4 are the predominant 
      risk factors for developing AD. How these risk factors interact to influence DMN 
      connectivity and connectivity-cognition relationships before the onset of 
      impairment remains unknown. Here, we examined these issues in 475 cognitively 
      normal adults, targeting total DMN connectivity, its anticorrelated network 
      (acDMN), and the DMN-hippocampal component. There were four main findings. First, 
      in the varepsilon3 homozygous group, lower DMN and acDMN connectivity was observed with 
      age. Second, sex and varepsilon4 modified the relationship between age and connectivity 
      for the DMN and hippocampus with varepsilon4 vs. varepsilon3 males showing sustained or higher 
      connectivity with age. Third, in the varepsilon3 group, age and sex modified 
      connectivity-cognition relationships with the oldest participants having the most 
      differential patterns due to sex. Fourth, varepsilon4 carriers with lower connectivity had 
      poorer cognitive performance. Taken together, our results show the three 
      predominant risk factors for AD interact to influence brain function and 
      function-cognition relationships.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Shafer, Andrea T
AU  - Shafer AT
AD  - Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, 
      MD. Electronic address: andrea.shafer@nih.gov.
FAU - Beason-Held, Lori
AU  - Beason-Held L
AD  - Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, 
      MD.
FAU - An, Yang
AU  - An Y
AD  - Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, 
      MD.
FAU - Williams, Owen A
AU  - Williams OA
AD  - Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, 
      MD.
FAU - Huo, Yuankai
AU  - Huo Y
AD  - Department of Electrical Engineering & Computer Science, Vanderbilt University, 
      Nashville, TN.
FAU - Landman, Bennett A
AU  - Landman BA
AD  - Department of Electrical Engineering & Computer Science, Vanderbilt University, 
      Nashville, TN.
FAU - Caffo, Brian S
AU  - Caffo BS
AD  - Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, 
      MD.
FAU - Resnick, Susan M
AU  - Resnick SM
AD  - Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, 
      MD. Electronic address: resnicks@nih.gov.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20210402
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Apolipoproteins E)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology/*psychology
MH  - Alzheimer Disease/*etiology/psychology
MH  - Apolipoproteins E/*genetics
MH  - *Cognition
MH  - Female
MH  - *Genotype
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*physiology
MH  - Risk Factors
MH  - *Sex Characteristics
OTO - NOTNLM
OT  - Aging
OT  - Apolipoprotein
OT  - Cognition
OT  - Connectivity
OT  - Default mode network
EDAT- 2021/05/07 06:00
MHDA- 2021/12/24 06:00
CRDT- 2021/05/06 20:43
PHST- 2020/09/03 00:00 [received]
PHST- 2021/03/04 00:00 [revised]
PHST- 2021/03/24 00:00 [accepted]
PHST- 2021/05/07 06:00 [pubmed]
PHST- 2021/12/24 06:00 [medline]
PHST- 2021/05/06 20:43 [entrez]
AID - S0197-4580(21)00111-1 [pii]
AID - 10.1016/j.neurobiolaging.2021.03.013 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2021 Aug;104:10-23. doi: 10.1016/j.neurobiolaging.2021.03.013. 
      Epub 2021 Apr 2.