PMID- 33957975
OWN - NLM
STAT- MEDLINE
DCOM- 20210519
LR  - 20220531
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 14
IP  - 1
DP  - 2021 May 6
TI  - Association of 45-bp ins/del polymorphism of uncoupling protein 2 (UCP2) and 
      susceptibility to nonalcoholic fatty liver and type 2 diabetes mellitus in 
      North-west of Iran.
PG  - 169
LID - 10.1186/s13104-021-05586-9 [doi]
LID - 169
AB  - OBJECTIVE: Uncoupling protein 2 (UCP2) plays a crucial role in energy homeostasis 
      via insulin secretion regulation, free fatty acid concentrations, and lipid 
      metabolism. This study aimed to investigate the association of 45-bp ins/del 
      polymorphism of UCP2 with susceptibility to NAFLD (Non-Alcoholic Fatty Liver 
      Disease) and T2DM (Type 2 Diabetes Mellitus). DNA was extracted from the white 
      blood cells of the subjects, and the gene polymorphism was determined using 
      polymerase chain reaction (PCR). In this study, 72 patients with NAFLD, 71 
      healthy individuals as control, 80 patients with T2DM, and 77 healthy controls 
      were enrolled in the study. RESULTS: A higher prevalence of insertion/insertion 
      genotype was observed in T2DM patients compared to the controls (p- value< 0.05). 
      There was no difference in genotype distribution between NAFLD patients and 
      controls (p-value > 0.05). NAFLD patients with D/D, D/I genotype had higher 
      triglyceride, ALT, and AST levels; however, their HDL levels were lower than 
      healthy controls. Patients with T2DM with D/D or D/I genotype also had 
      significantly higher fasting serum glucose (FSG). While we found an association 
      between the 45 bp I/D polymorphism in 3'UTR of UCP2 and T2DM, no correlation 
      between this polymorphism and NAFLD was identified.
FAU - Rezapour, Saleheh
AU  - Rezapour S
AD  - Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
AD  - Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Khosroshahi, Shiva Ahdi
AU  - Khosroshahi SA
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Farajnia, Hadi
AU  - Farajnia H
AD  - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Mohseni, Fatemeh
AU  - Mohseni F
AD  - Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Khoshbaten, Manouchehr
AU  - Khoshbaten M
AD  - Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Farajnia, Safar
AU  - Farajnia S
AUID- ORCID: 0000-0002-6087-9147
AD  - Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran. farajnias@tbzmed.ac.ir.
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran. farajnias@tbzmed.ac.ir.
LA  - eng
GR  - 59338/Biotechnology Research Center, Tabriz University of Medical Sciences/
PT  - Journal Article
DEP - 20210506
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
RN  - 0 (UCP2 protein, human)
RN  - 0 (Uncoupling Protein 2)
SB  - IM
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Humans
MH  - Iran
MH  - *Non-alcoholic Fatty Liver Disease/genetics
MH  - Polymorphism, Genetic
MH  - Uncoupling Protein 2/genetics
PMC - PMC8101211
OTO - NOTNLM
OT  - 45 bp I/D polymorphism
OT  - NAFLD
OT  - T2DM
OT  - UCP2
COIS- The authors declare that they have no competing interests.
EDAT- 2021/05/08 06:00
MHDA- 2021/05/20 06:00
PMCR- 2021/05/06
CRDT- 2021/05/07 06:20
PHST- 2020/07/05 00:00 [received]
PHST- 2021/04/24 00:00 [accepted]
PHST- 2021/05/07 06:20 [entrez]
PHST- 2021/05/08 06:00 [pubmed]
PHST- 2021/05/20 06:00 [medline]
PHST- 2021/05/06 00:00 [pmc-release]
AID - 10.1186/s13104-021-05586-9 [pii]
AID - 5586 [pii]
AID - 10.1186/s13104-021-05586-9 [doi]
PST - epublish
SO  - BMC Res Notes. 2021 May 6;14(1):169. doi: 10.1186/s13104-021-05586-9.