PMID- 33959048
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230920
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 12
DP  - 2021
TI  - Neural Correlates of Mentalizing in Individuals With Clinical High Risk for 
      Schizophrenia: ALE Meta-Analysis.
PG  - 634015
LID - 10.3389/fpsyt.2021.634015 [doi]
LID - 634015
AB  - Psychotic disorder refers to a spectrum of disorders that have multiple 
      etiologies, due to the complex interaction of biological and genetic 
      vulnerability with familial and cultural factors. A clinical high risk (CHR) for 
      schizophrenia is defined as the presence of brief, attenuated, or intermittent 
      psychotic symptoms in non-schizophrenic individuals. The transition to 
      schizophrenia appears significantly more frequent in this at-risk population than 
      in the general population. Moreover, the ability to attribute mental states to 
      others, known as mentalizing or theory of mind, and its neural correlates found 
      in individuals with CHR are similar to those described in patients with 
      schizophrenia. We have therefore explored neurofunctional correlates of 
      mentalizing in individuals with CHR vs. healthy controls, in order to identify 
      the differences in brain activation. A neural coordinate-based activation 
      likelihood estimation meta-analysis of existing neuroimaging data revealed that 
      three regions displayed decreased activation in individuals with CHR, compared 
      with healthy controls: the right temporoparietal junction, the right middle 
      temporal gyrus, and the left precuneus. These results, combined with those in the 
      literature, further support the hypothesis that abnormal activation of posterior 
      brain regions involved in mentalizing correlates with psychotic symptoms in 
      help-seeking individuals.
CI  - Copyright (c) 2021 Vucurovic, Caillies and Kaladjian.
FAU - Vucurovic, Ksenija
AU  - Vucurovic K
AD  - Laboratory Cognition, Sante, Societe (C2S), Department of Psychology, University 
      of Reims Champagne Ardenne, Reims, France.
AD  - Centre Remois de Psychotherapie et Neuromodulation, Reims, France.
FAU - Caillies, Stephanie
AU  - Caillies S
AD  - Laboratory Cognition, Sante, Societe (C2S), Department of Psychology, University 
      of Reims Champagne Ardenne, Reims, France.
FAU - Kaladjian, Arthur
AU  - Kaladjian A
AD  - Laboratory Cognition, Sante, Societe (C2S), Department of Psychology, University 
      of Reims Champagne Ardenne, Reims, France.
AD  - Pole Universitaire de Psychiatrie, CHU de Reims, EPSM Marne, Reims, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210420
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC8095711
OTO - NOTNLM
OT  - fMRI
OT  - psychosis proneness
OT  - schizophrenia
OT  - social cognition
OT  - theory of mind
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/05/08 06:00
MHDA- 2021/05/08 06:01
PMCR- 2021/04/20
CRDT- 2021/05/07 07:09
PHST- 2020/11/26 00:00 [received]
PHST- 2021/02/25 00:00 [accepted]
PHST- 2021/05/07 07:09 [entrez]
PHST- 2021/05/08 06:00 [pubmed]
PHST- 2021/05/08 06:01 [medline]
PHST- 2021/04/20 00:00 [pmc-release]
AID - 10.3389/fpsyt.2021.634015 [doi]
PST - epublish
SO  - Front Psychiatry. 2021 Apr 20;12:634015. doi: 10.3389/fpsyt.2021.634015. 
      eCollection 2021.