PMID- 33960253
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20220716
IS  - 1521-0464 (Electronic)
IS  - 1071-7544 (Print)
IS  - 1071-7544 (Linking)
VI  - 28
IP  - 1
DP  - 2021 Dec
TI  - Exosome loaded genipin crosslinked hydrogel facilitates full thickness cutaneous 
      wound healing in rat animal model.
PG  - 884-893
LID - 10.1080/10717544.2021.1912210 [doi]
AB  - Full thickness cutaneous wound therapy and regeneration remains a critical 
      challenge in clinical therapeutics. Recent reports have suggested that 
      mesenchymal stem cells exosomes therapy is a promising technology with great 
      potential to efficiently promote tissue regeneration. Multifunctional hydrogel 
      composed of both synthetic materials and natural materials is an effective 
      carrier for exosomes loading. Herein, we constructed a biodegradable, 
      dual-sensitive hydrogel encapsulated human umbilical cord-mesenchymal stem cells 
      (hUCMSCs) derived exosomes to facilitate wound healing and skin regeneration 
      process. The materials characterization, exosomes identification, and in vivo 
      full-thickness cutaneous wound healing effect of the hydrogels were performed and 
      evaluated. The in vivo results demonstrated the exosomes loaded hydrogel had 
      significantly improved wound closure, re-epithelialization rates, collagen 
      deposition in the wound sites. More skin appendages were observed in exosomes 
      loaded hydrogel treated wound, indicating the potential to achieve complete skin 
      regeneration. This study provides a new access for complete cutaneous wound 
      regeneration via a genipin crosslinked dual-sensitive hydrogel loading hUCMSCs 
      derived exosomes.
FAU - Li, Qijun
AU  - Li Q
AUID- ORCID: 0000-0003-0635-9025
AD  - Department of Pharmacology, School of Pharmacy, China Medical University, 
      Shenyang, PR China.
FAU - Gong, Shiqiang
AU  - Gong S
AD  - Department of Pharmacology, School of Pharmacy, China Medical University, 
      Shenyang, PR China.
FAU - Yao, Weifan
AU  - Yao W
AD  - Department of Pharmacology, School of Pharmacy, China Medical University, 
      Shenyang, PR China.
FAU - Yang, Ziting
AU  - Yang Z
AD  - Department of Pharmacology, School of Pharmacy, China Medical University, 
      Shenyang, PR China.
FAU - Wang, Renjun
AU  - Wang R
AD  - Department of Pharmacology, School of Pharmacy, China Medical University, 
      Shenyang, PR China.
FAU - Yu, Zhaojin
AU  - Yu Z
AUID- ORCID: 0000-0002-0438-5601
AD  - Department of Pharmacology, School of Pharmacy, China Medical University, 
      Shenyang, PR China.
FAU - Wei, Minjie
AU  - Wei M
AUID- ORCID: 0000-0001-5548-7280
AD  - Department of Pharmacology, School of Pharmacy, China Medical University, 
      Shenyang, PR China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Drug Deliv
JT  - Drug delivery
JID - 9417471
RN  - 0 (Hydrogels)
RN  - 0 (Iridoids)
RN  - 9007-34-5 (Collagen)
RN  - A3V2NE52YG (genipin)
SB  - IM
MH  - Animals
MH  - Cell Movement/drug effects
MH  - Collagen/metabolism
MH  - Drug Liberation
MH  - Exosomes/*metabolism
MH  - Female
MH  - Hydrogels/*chemistry
MH  - Hydrogen-Ion Concentration
MH  - Iridoids/administration & dosage/*pharmacology
MH  - Mesenchymal Stem Cells/drug effects
MH  - Particle Size
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin/*drug effects
MH  - Wound Healing/*drug effects
PMC - PMC8118534
OTO - NOTNLM
OT  - genipin crosslinked hydrogel
OT  - hUCMSCs derived exosome
OT  - rat model
OT  - skin tissue regeneration
OT  - wound healing
COIS- The authors declare no conflict of interest.
EDAT- 2021/05/08 06:00
MHDA- 2021/11/16 06:00
PMCR- 2021/05/07
CRDT- 2021/05/07 08:48
PHST- 2021/05/07 08:48 [entrez]
PHST- 2021/05/08 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/05/07 00:00 [pmc-release]
AID - 1912210 [pii]
AID - 10.1080/10717544.2021.1912210 [doi]
PST - ppublish
SO  - Drug Deliv. 2021 Dec;28(1):884-893. doi: 10.1080/10717544.2021.1912210.