PMID- 33960564
OWN - NLM
STAT- MEDLINE
DCOM- 20220324
LR  - 20220324
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Print)
IS  - 1015-6305 (Linking)
VI  - 31
IP  - 6
DP  - 2021 Nov
TI  - Antenatal low-intensity pulsed ultrasound reduces neurobehavioral deficits and 
      brain injury following dexamethasone-induced intrauterine growth restriction.
PG  - e12968
LID - 10.1111/bpa.12968 [doi]
LID - e12968
AB  - Intrauterine growth restriction (IUGR) is a leading cause of perinatal mortality 
      and morbidity, and IUGR survivors are at increased risk of neurodevelopmental 
      deficits. No effective interventions are currently available to improve the 
      structure and function of the IUGR brain before birth. This study investigated 
      the protective effects of low-intensity pulsed ultrasound (LIPUS) on postnatal 
      neurodevelopmental outcomes and brain injury using a rat model of IUGR induced by 
      maternal exposure to dexamethasone (DEX). Pregnant rats were treated with DEX 
      (200 mug/kg, s.c.) and LIPUS daily from gestational day (GD) 14 to 19. Behavioral 
      assessments were performed on the IUGR offspring to examine neurological 
      function. Neuropathology, levels of neurotrophic factors, and CaMKII-Akt-related 
      molecules were assessed in the IUGR brain, and expression of glucose and amino 
      acid transporters and neurotrophic factors were examined in the 
      placenta. Maternal LIPUS treatment increased fetal weight, fetal liver weight, 
      and placental weight following IUGR. LIPUS treatment also increased neuronal 
      number and myelin protein expression in the IUGR brain, and attenuated 
      neurodevelopmental deficits at postnatal day (PND) 18. However, the number of 
      oligodendrocytes or microglia was not affected. These changes were associated 
      with the upregulation of brain-derived neurotrophic factor (BDNF) and placental 
      growth factor (PlGF) protein expression, and enhancement of neuronal CaMKII and 
      Akt activation in the IUGR brain at PND 1. Additionally, LIPUS treatment promoted 
      glucose transporter (GLUT) 1 production and BDNF expression in the placenta, but 
      had no effects on GLUT3 or amino acid transporter expression. Our findings 
      suggest that antenatal LIPUS treatment may reduce IUGR-induced brain injury via 
      enhancing cerebral BDNF/CaMKII/Akt signaling. These data provide new evidence 
      that LIPUS stimulation could be considered for antenatal neuroprotective therapy 
      in IUGR.
CI  - (c) 2021 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf 
      of International Society of Neuropathology.
FAU - Hung, Tai-Ho
AU  - Hung TH
AD  - Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, 
      Taipei, Taiwan.
AD  - Department of Obstetrics and Gynecology, Keelung Chang Gung Memorial Hospital, 
      Keelung, Taiwan.
AD  - College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Liu, Yu-Cheng
AU  - Liu YC
AD  - Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, 
      Taipei, Taiwan.
AD  - Department of Biomedical Imaging and Radiological Sciences, National Yang Ming 
      Chiao Tung University, Taipei, Taiwan.
FAU - Wu, Chun-Hu
AU  - Wu CH
AD  - Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Chen, Chien-Cheng
AU  - Chen CC
AD  - Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, 
      Taipei, Taiwan.
AD  - Graduate Institute of Gerontology and Health Care Management, Chang Gung 
      University of Science and Technology, Taoyuan, Taiwan.
FAU - Chao, Hsien
AU  - Chao H
AD  - School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
FAU - Yang, Feng-Yi
AU  - Yang FY
AD  - Department of Biomedical Imaging and Radiological Sciences, National Yang Ming 
      Chiao Tung University, Taipei, Taiwan.
FAU - Chen, Szu-Fu
AU  - Chen SF
AUID- ORCID: 0000-0002-8398-883X
AD  - Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, 
      Taipei, Taiwan.
AD  - Department of Physiology and Biophysics, National Defense Medical Center, Taipei, 
      Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210507
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Body Weight/*physiology
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Dexamethasone
MH  - Disease Models, Animal
MH  - Female
MH  - Fetal Growth Retardation/chemically induced/metabolism/*therapy
MH  - Microglia/metabolism
MH  - Motor Activity/physiology
MH  - Motor Skills/physiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
MH  - *Ultrasonic Waves
PMC - PMC8549022
OTO - NOTNLM
OT  - CaMKII
OT  - brain injury
OT  - intrauterine growth restriction
OT  - neurotrophic factor
OT  - ultrasound
COIS- The authors have no competing financial interests to disclose.
EDAT- 2021/05/08 06:00
MHDA- 2022/03/25 06:00
PMCR- 2021/05/07
CRDT- 2021/05/07 09:12
PHST- 2021/04/01 00:00 [revised]
PHST- 2021/01/10 00:00 [received]
PHST- 2021/04/06 00:00 [accepted]
PHST- 2021/05/08 06:00 [pubmed]
PHST- 2022/03/25 06:00 [medline]
PHST- 2021/05/07 09:12 [entrez]
PHST- 2021/05/07 00:00 [pmc-release]
AID - BPA12968 [pii]
AID - 10.1111/bpa.12968 [doi]
PST - ppublish
SO  - Brain Pathol. 2021 Nov;31(6):e12968. doi: 10.1111/bpa.12968. Epub 2021 May 7.