PMID- 33962058 OWN - NLM STAT- MEDLINE DCOM- 20210630 LR - 20210630 IS - 1873-1597 (Electronic) IS - 1572-1000 (Linking) VI - 34 DP - 2021 Jun TI - Comparison of retinal nerve fiber layer, macular ganglion cell complex and choroidal thickness in patients with migraine with and without aura by using optical coherence tomography. PG - 102323 LID - S1572-1000(21)00149-6 [pii] LID - 10.1016/j.pdpdt.2021.102323 [doi] AB - BACKGROUND: We compared the choroidal thickness (CT), peripapillary retinal nerve fibre layer thickness (pRNFLT) and macular ganglion cell complex thickness (mGCCT) by using spectral domain optic coherence tomography (SD-OCT) in patients with migraine with aura (MWA), migraine without aura (MWoA), and healthy controls. METHODS: Thirty-seven patients with MWA, 40 patients with MWoA, and age and sex-matched 50 healthy controls were included in this cross-sectional study. CTs at fovea, nasal to fovea and temporal to fovea, global pRNFLT, four quadrants of pRNFLTs, mGCCTs in superior and inferior hemisphere were measured by SD-OCT. The duration of migraine, monthly attack number and the migraine disability assessment (MIDAS) questionnaire scores were recorded. RESULTS: The mean foveal CT, nasal CT, and temporal CT in patients with MWA were significantly thinner than those of patients with MWoA and control (p < 0.001) while CTs of patients with MWoA were similar with those of controls. Patients with MWA and MWoA had thinner global pRNFLT, superior and inferior pRNFLT compared to controls but there were no significant differences between two migraineurs groups. Only nasal quadrant of pRNFLT was significantly thinner in patients with MWA than other groups. The superior and inferior mGCCTs were significantly thinner in patients with MWA and MWoA than controls. CONCLUSION: Our results suggested that dysregulation of blood flow in ocular tissues caused by impairment of autoregulation in migraine. Patients with MWA might have an additional risk of choroidal and retinal ischemia than patients with MWoA and healthy controls. CI - Copyright (c) 2021. Published by Elsevier B.V. FAU - Kanar, Hatice Selen AU - Kanar HS AD - Health Science University, Kartal Dr. Lutfi Kirdar Trainig and Research HospItal, Department of Ophthalmology, Cevizli, D-100 Guney Yanyol, Cevizli Mevkii No:47, 34865 Kartal, Istanbul, Turkey. Electronic address: hselensonmez@hotmail.com. FAU - Toz, Hilal Tastekin AU - Toz HT AD - Health Science University, Kartal Dr. Lutfi Kirdar Trainig and Research Hospital, Department of Neurology, Cevizli, D-100 Guney Yanyol, Cevizli Mevkii No:47, 34865 Kartal, Istanbul, Turkey. Electronic address: hilaltastekin@hotmail.com. FAU - Penbe, Aysegul AU - Penbe A AD - Health Science University, Kartal Dr. Lutfi Kirdar Trainig and Research HospItal, Department of Ophthalmology, Cevizli, D-100 Guney Yanyol, Cevizli Mevkii No:47, 34865 Kartal, Istanbul, Turkey. Electronic address: draysegulp@yahoo.com. LA - eng PT - Journal Article DEP - 20210504 PL - Netherlands TA - Photodiagnosis Photodyn Ther JT - Photodiagnosis and photodynamic therapy JID - 101226123 RN - 0 (Photosensitizing Agents) SB - IM MH - Cross-Sectional Studies MH - *Epilepsy MH - Humans MH - *Migraine Disorders MH - Nerve Fibers MH - *Photochemotherapy/methods MH - Photosensitizing Agents MH - Retinal Ganglion Cells MH - Tomography, Optical Coherence OTO - NOTNLM OT - Aura OT - Choroidal thickness OT - Ganglion cell complex thickness OT - Migraine OT - Retinal nerve fiber layer thickness OT - Spectral domain optic coherence tomography EDAT- 2021/05/08 06:00 MHDA- 2021/07/01 06:00 CRDT- 2021/05/07 20:23 PHST- 2021/03/21 00:00 [received] PHST- 2021/04/24 00:00 [revised] PHST- 2021/04/30 00:00 [accepted] PHST- 2021/05/08 06:00 [pubmed] PHST- 2021/07/01 06:00 [medline] PHST- 2021/05/07 20:23 [entrez] AID - S1572-1000(21)00149-6 [pii] AID - 10.1016/j.pdpdt.2021.102323 [doi] PST - ppublish SO - Photodiagnosis Photodyn Ther. 2021 Jun;34:102323. doi: 10.1016/j.pdpdt.2021.102323. Epub 2021 May 4.