PMID- 33962200
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1095-7103 (Electronic)
IS  - 0021-9797 (Linking)
VI  - 599
DP  - 2021 Oct
TI  - Titanium carbide/zeolite imidazole framework-8/polylactic acid electrospun 
      membrane for near-infrared regulated photothermal/photodynamic therapy of 
      drug-resistant bacterial infections.
PG  - 390-403
LID - S0021-9797(21)00625-1 [pii]
LID - 10.1016/j.jcis.2021.04.109 [doi]
AB  - Bacteria induced wound infection has become fatal healthcare issues needed to be 
      resolved urgently. It is of vital importance to develop multifunctional 
      therapeutic platforms to fight against increased bacterial antibiotic resistance. 
      Herein, a titanium carbide (MXene)/zeolite imidazole framework-8 
      (ZIF-8)/polylactic acid (PLA) composite membrane (MZ-8/PLA) was fabricated 
      through in-situ growth of ZIF-8 on MXene and the subsequent electrospinning 
      process. It indicated MZ-8 can generate singlet oxygen and hyperthermia at 
      photothermal (PTT) convention efficiency of 80.5% with bactericidal rate of more 
      than 99.0%. In addition, MZ-8 showed remarkable antitumor efficiency in vitro and 
      in vivo based on the combined photodynamic/photothermal therapy. Theoretical 
      calculation illustrated MZ-8 could improve the laser activation process by 
      acceleration of intermolecular charge transfer, reducing excitation energy, 
      stabilizing excited states and increasing intersystem crossing rate. After 
      incorporated into electrospun scaffolds, MZ-8/PLA exhibited potent PTT and 
      photodynamic therapy (PDT) properties under 808 nm laser irradiation. The 
      antibacterial rates of MZ-8/PLA were up to 99.9% and 99.8% against Escherichia 
      coli and Methicillin-resistant staphylococcus aureus, respectively. In-vivo 
      experimental results further confirmed that MZ-8/PLA can accelerate bacteria 
      infected wound healing without observable resistance. This work opens a new 
      avenue to design promising platforms for fighting against extremely drug 
      resistant bacterial infection.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Zhang, Siqi
AU  - Zhang S
AD  - State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian 
      University of Technology, 2 Linggong Road, Dalian, Liaoning 116024, PR China.
FAU - Ye, Junwei
AU  - Ye J
AD  - State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian 
      University of Technology, 2 Linggong Road, Dalian, Liaoning 116024, PR China. 
      Electronic address: junweiye@dlut.edu.cn.
FAU - Liu, Xin
AU  - Liu X
AD  - State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian 
      University of Technology, 2 Linggong Road, Dalian, Liaoning 116024, PR China.
FAU - Wang, Ye
AU  - Wang Y
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Dalian Medical University, No. 9 West Section Lvshun South Road, Dalian, Liaoning 
      116044, PR China.
FAU - Li, Chao
AU  - Li C
AD  - State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian 
      University of Technology, 2 Linggong Road, Dalian, Liaoning 116024, PR China.
FAU - Fang, Jiatong
AU  - Fang J
AD  - State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian 
      University of Technology, 2 Linggong Road, Dalian, Liaoning 116024, PR China.
FAU - Chang, Baoning
AU  - Chang B
AD  - State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian 
      University of Technology, 2 Linggong Road, Dalian, Liaoning 116024, PR China.
FAU - Qi, Ye
AU  - Qi Y
AD  - State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian 
      University of Technology, 2 Linggong Road, Dalian, Liaoning 116024, PR China.
FAU - Li, Yachen
AU  - Li Y
AD  - Department of Occupational and Environmental Health, School of Public Health, 
      Dalian Medical University, No. 9 West Section Lvshun South Road, Dalian, Liaoning 
      116044, PR China. Electronic address: liy76@yahoo.com.
FAU - Ning, Guiling
AU  - Ning G
AD  - State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian 
      University of Technology, 2 Linggong Road, Dalian, Liaoning 116024, PR China. 
      Electronic address: ninggl@dlut.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210424
PL  - United States
TA  - J Colloid Interface Sci
JT  - Journal of colloid and interface science
JID - 0043125
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Imidazoles)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Polyesters)
RN  - 12070-08-5 (titanium carbide)
RN  - 1318-02-1 (Zeolites)
RN  - 459TN2L5F5 (poly(lactide))
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Anti-Bacterial Agents/pharmacology
MH  - Bacteria
MH  - *Bacterial Infections/drug therapy
MH  - Humans
MH  - Imidazoles
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - *Pharmaceutical Preparations
MH  - *Photochemotherapy
MH  - Polyesters
MH  - Titanium
MH  - *Zeolites
OTO - NOTNLM
OT  - Antibacterial activity
OT  - Electrospun
OT  - MXene/ZIF-8 composites
OT  - Photodynamic
OT  - Photothermal
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/05/08 06:00
MHDA- 2021/06/22 06:00
CRDT- 2021/05/07 20:30
PHST- 2021/02/04 00:00 [received]
PHST- 2021/04/19 00:00 [revised]
PHST- 2021/04/20 00:00 [accepted]
PHST- 2021/05/08 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/05/07 20:30 [entrez]
AID - S0021-9797(21)00625-1 [pii]
AID - 10.1016/j.jcis.2021.04.109 [doi]
PST - ppublish
SO  - J Colloid Interface Sci. 2021 Oct;599:390-403. doi: 10.1016/j.jcis.2021.04.109. 
      Epub 2021 Apr 24.