PMID- 33962506
OWN - NLM
STAT- MEDLINE
DCOM- 20220901
LR  - 20220920
IS  - 1553-3840 (Electronic)
IS  - 1553-3840 (Linking)
VI  - 19
IP  - 2
DP  - 2022 Jun 1
TI  - Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and 
      inflammation in LPS-induced acute lung injury mice.
PG  - 261-267
LID - 10.1515/jcim-2021-0045 [doi]
AB  - OBJECTIVES: Acute lung injury (ALI) is a life-threatening pulmonary dysfunction 
      associated with severe inflammation. There are still no effective pharmacological 
      therapies for the treatment of ALI. In this concern, several anti-inflammatory 
      agents could be used as add-on therapy to inhibit inflammation. Achillea 
      wilhelmsii (AW) C. Koch is a well-known medicinal plant in the Iranian 
      ethnomedical practices with anti-inflammatory activity. This study was aimed to 
      evaluate the efficacy of ethanolic extract of AW on lipopolysaccharide 
      (LPS)-induced ALI in mice. METHODS: The ALI model was established via the 
      intra-tracheal (i.t.) administration of LPS (2 mg/kg) to male BALB/c mice. The 
      ALI mice were divided into four groups (n=8 each) which intra-peritoneally (i.p.) 
      treated with repeated doses of saline (model), dexamethasone (2 mg/kg), and AW 
      (150-300 mg/kg) 1, 11 and 23 h post LPS administration. Twenty-four hours after 
      the LPS challenge, bronchoalveolar lavage fluid (BALF) and lung tissue were 
      evaluated for inflammatory cell influx, level of tumor necrosis factor-alpha (TNF-alpha) 
      and histopathological changes. RESULTS: The AW (150-300 mg/kg) treated mice 
      showed lower inflammatory cells infiltration in BALF and TNF-alpha level when 
      compared to the model group. In addition, LPS induced several pathological 
      alterations such as edema, alveolar hemorrhage and inflammatory cell infiltration 
      into the interstitium and alveolar spaces. Treatment with AW significantly 
      reduced LPS-induced pathological injury. CONCLUSIONS: Taken together, the data 
      here indicated that AW may be considered as a promising add-on therapy for ALI.
CI  - (c) 2021 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Honari, Niloofar
AU  - Honari N
AD  - Student Research Committee, Birjand University of Medical Sciences, Birjand, 
      Iran.
FAU - Shaban, Parastoo
AU  - Shaban P
AD  - Student Research Committee, Birjand University of Medical Sciences, Birjand, 
      Iran.
FAU - Nasseri, Saeed
AU  - Nasseri S
AD  - Cellular and Molecular Research Center, Department of Molecular Medicine, Birjand 
      University of Medical Sciences, Birjand, Iran.
FAU - Hosseini, Mehran
AU  - Hosseini M
AUID- ORCID: 0000-0002-6793-2035
AD  - Cellular and Molecular Research Center, Department of Anatomical Sciences, 
      Birjand University of Medical Sciences, Birjand, Iran.
LA  - eng
PT  - Journal Article
DEP - 20210506
PL  - Germany
TA  - J Complement Integr Med
JT  - Journal of complementary & integrative medicine
JID - 101313855
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - *Achillea
MH  - *Acute Lung Injury/chemically induced/drug therapy/pathology
MH  - Animals
MH  - Anti-Inflammatory Agents/adverse effects
MH  - Inflammation/drug therapy
MH  - Iran
MH  - Lipopolysaccharides/adverse effects
MH  - Lung/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plant Extracts/adverse effects
MH  - Tumor Necrosis Factor-alpha
OTO - NOTNLM
OT  - Achillea
OT  - acute lung injury
OT  - inflammation
OT  - lipopolysaccharide
OT  - tumor necrosis factor-alpha
EDAT- 2021/05/08 06:00
MHDA- 2022/09/02 06:00
CRDT- 2021/05/07 20:48
PHST- 2021/01/30 00:00 [received]
PHST- 2021/04/06 00:00 [accepted]
PHST- 2021/05/08 06:00 [pubmed]
PHST- 2022/09/02 06:00 [medline]
PHST- 2021/05/07 20:48 [entrez]
AID - jcim-2021-0045 [pii]
AID - 10.1515/jcim-2021-0045 [doi]
PST - epublish
SO  - J Complement Integr Med. 2021 May 6;19(2):261-267. doi: 10.1515/jcim-2021-0045. 
      eCollection 2022 Jun 1.