PMID- 33962597 OWN - NLM STAT- MEDLINE DCOM- 20210524 LR - 20210524 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 21 IP - 1 DP - 2021 May 7 TI - Associations of midpoint of sleep and night sleep duration with type 2 diabetes mellitus in Chinese rural population: the Henan rural cohort study. PG - 879 LID - 10.1186/s12889-021-10833-6 [doi] LID - 879 AB - BACKGROUND: The study aimed to investigate the independent and combined effects of midpoint of sleep and night sleep duration on type 2 diabetes mellitus (T2DM) in areas with limited resources. METHODS: A total of 37,276 participants (14,456 men and 22,820 women) were derived from the Henan Rural Cohort Study. Sleep information was assessed based on the Pittsburgh Sleep Quality Index. Logistic regression models and restricted cubic splines were used to estimate the relationship of the midpoint of sleep and night sleep duration with T2DM. RESULTS: Of the 37,276 included participants, 3580 subjects suffered from T2DM. The mean midpoint of sleep among the Early, Intermediate and Late groups were 1:05 AM +/-23 min, 1:56 AM +/-14 min, and 2:57 AM +/-34 min, respectively. Compared to the Intermediate group, adjusted odds ratios (ORs) and 95% confidence interval (CI) of T2DM were 1.13 (1.04-1.22) and 1.14 (1.03-1.26) in the Early group and the Late group. Adjusted OR (95% CI) for T2DM compared with the reference (7- h) was 1.28 (1.08-1.51) for longer (>/= 10 h) night sleep duration. The combination of late midpoint of sleep and night sleep duration (>/= 9 h) increased 38% (95% CI 10-74%) prevalence of T2DM. These associations were more obvious in women than men. CONCLUSIONS: Late and early midpoint of sleep and long night sleep duration were all associated with higher prevalence of T2DM. Meanwhile, midpoint of sleep and night sleep duration might have combined effects on the prevalence of T2DM, which provided potential health implications for T2DM prevention, especially in rural women. TRIAL REGISTRATION: The Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699 ). Date of registration: 2015-07-06. FAU - Zhai, Zhihan AU - Zhai Z AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. FAU - Liu, Xiaotian AU - Liu X AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. FAU - Zhang, Haiqing AU - Zhang H AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. FAU - Dong, Xiaokang AU - Dong X AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. FAU - He, Yaling AU - He Y AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. FAU - Niu, Miaomiao AU - Niu M AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. FAU - Pan, Mingming AU - Pan M AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. AD - Department of Preventive Medicine, Henan University of Chinese Medicine, 156 East Jinshui, Zhengzhou, Henan, 450046, PR China. FAU - Wang, Chongjian AU - Wang C AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. FAU - Wang, Xiaoqiong AU - Wang X AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. xwzty@126.com. AD - Department of Economics, Business School, Zhengzhou University, Zhengzhou, Henan, PR China. xwzty@126.com. FAU - Li, Yuqian AU - Li Y AUID- ORCID: 0000-0003-1276-0077 AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China. liyuqian@zzu.edu.cn. AD - Department of Clinical Pharmacology, School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, PR China. liyuqian@zzu.edu.cn. LA - eng SI - ChiCTR/ChiCTR-OOC-15006699 GR - 2016YFC0900803/Foundation of National Key Program of Research and Development of China/ GR - 81573243, 81602925/National Natural Science Foundation of China/ GR - 201702367, 2017T02098/Foundation of Medical Science and Technology of Henan province/ GR - 182300410293/Henan Natural Science Foundation of China/ GR - XKZDQY202008, XKZDQY202002/Discipline Key Research and Development Program of Zhengzhou University/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210507 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - China/epidemiology MH - Cohort Studies MH - *Diabetes Mellitus, Type 2/epidemiology MH - Female MH - Humans MH - Male MH - Risk Factors MH - Rural Population MH - Sleep PMC - PMC8106181 OTO - NOTNLM OT - Midpoint of sleep OT - Night sleep duration OT - Rural population OT - Type 2 diabetes mellitus COIS- The authors declare that they have no competing interests. EDAT- 2021/05/09 06:00 MHDA- 2021/05/25 06:00 PMCR- 2021/05/07 CRDT- 2021/05/08 06:07 PHST- 2020/11/10 00:00 [received] PHST- 2021/04/13 00:00 [accepted] PHST- 2021/05/08 06:07 [entrez] PHST- 2021/05/09 06:00 [pubmed] PHST- 2021/05/25 06:00 [medline] PHST- 2021/05/07 00:00 [pmc-release] AID - 10.1186/s12889-021-10833-6 [pii] AID - 10833 [pii] AID - 10.1186/s12889-021-10833-6 [doi] PST - epublish SO - BMC Public Health. 2021 May 7;21(1):879. doi: 10.1186/s12889-021-10833-6.